Hexose transporter expression and function in mammalian spermatozoa: Cellular localization and transport of hexoses and vitamin C

Journal of Cellular Biochemistry

Volumn 71, Issue 2, 1998, Pages 189-203

  Angulo, Constanza ^a   Rauch, María Cecilia ^a   Droppelmann, Andrea ^a   Reyes, Alejandro M ^a   Slebe, Juan Carlos ^a   Delgado López, Fernando ^b   Guaiquil, Victor H ^b   Vera, Juan Carlos ^b   Concha, Ilona I ^a  

^a UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

2 deoxy D glucose; Dehydroascorbic acid; Fructose; Glucose transporters; Sperm

Indexed keywords

ASCORBIC ACID; CYTOCHALASIN B; DEHYDROASCORBIC ACID; DEOXYGLUCOSE; FRUCTOSE; HEXOSE;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HEXOSE TRANSPORT; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEMEN ANALYSIS; SPECIES DIFFERENCE; SPERM; SPERMATOZOON;

ANIMALS; ASCORBIC ACID; BASE SEQUENCE; CATTLE; DNA PRIMERS; HEXOSES; HUMANS; MALE; MONOSACCHARIDE TRANSPORT PROTEINS; SPERMATOZOA;

ANIMALIA; MAMMALIA;

EID: 0031687120     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19981101)71:2<189::AID-JCB5>3.0.CO;2-R     Document Type: Article

References (48)

1. Aitken RJ, Clarkson JS (1988): Significance of reactive oxygen species and antioxidants in defining the efficacy of sperm preparation techniques. J Androl 9:367-376.
2. Birnbaum MJ (1989): Identification of a novel gene encoding an insulin-responsive glucose transporter protein. Cell 57:305-315.
3. Birnbaum MJ, Haspel HC, Rosen OM (1986): Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. Proc Natl Acad Sci USA 83:5784-5788.
4. Burant CF, Takeda J, Brot-Laroche E, Bell GI, Davidson NO (1992): Fructose transporter in human spermatozoa and small intestine is GLUT5. J Biol Chem 267:14523-14526.
5. Cailleau J, Vermeire S, Verhoeven G (1990): Independent control of the production of insulin-like growth factor I and its binding protein by cultured testicular cells. Mol Cell Endocrinol 69:79-89.
6. Carruthers A (1990): Facilitated diffusion of glucose. Physiol Rev 70:1135-1176.
7. Chinoy NJ, Mehta RR, Seethalakshmi L, Sharma JD, Chinoy MR (1986): Effects of vitamin C deficiency on physiology of male reproductive organs of guinea pigs. Int J Fertil 31:232-239.
8. Colville CA, Seatter MJ, Jess TJ, Gould GW, Thomas HM (1993): Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: Substrate specificities and effects of transport inhibitors. Biochem J 290:701-706.
9. Concha II, Velásquez FV, Martínez JM, Angulo C, Droppelmann A, Reyes AM, Slebe JC, Vera JC, Golde DW (1997): Human erythrocytes express GLUT5 and transport fructose. Blood 89:4190-4195.
10. Dawson EB, Harris WA, Rankin WE, Charpentier LA, McGanity WJ (1987): Effect of ascorbic acid on male fertility. Ann NY Acad Sci 498:312-323.
11. Dawson EB, Harris WA, Teter MC, Powell LC (1992): Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril 58:1034-1039.
12. Fraser LR, Quinn PJ (1981): A glycolytic product is obligatory for initiation of the sperm acrosome reaction and whiplash motility required for fertilization in the mouse. J Reprod Fertil 61:25-35.
13. Glander H-J, Dettmer D (1978a): Monosaccharide transport across membranes of human spermatozoa I. Development of a radiochemical method of measuring monosaccharide uptake by spermatozoa. Andrologia 10:69-73.
14. Glander H-J, Dettmer D (1978b): Monosaccharide transport across membranes of human spermatozoa II. Basic properties of D-fructose and D-glucose uptake. Andrologia 10:273-277.
15. Grootegoed JA, den Boer PJ (1990): Energy metabolism of spermatids: a review. In Hamilton DW, Waites GMH (eds): "Scientific Basis for Fertility Regulation. Cellular and Molecular Events in Spermiogenesis." Cambridge: Cambridge University Press, pp 193-216.
16. Haber RS, Weinstein SP, O'Boyle E, Morgello S (1993): Tissue distribution of the human GLUT3 glucose transporter. Endocrinology 132:2538-2543.
17. Hall PF, Nakamura M (1981): Influence of temperature on hexose transport by round spermatids of rats. J Reprod Fertil 63:373-379.
18. Hiipakka RA, Hammerstedt RH (1978a): 2-Deoxyglucose transport and phosphorylation by bovine sperm. Biol Reprod 19:368-379.
19. Hiipakka RA, Hammerstedt RH (1978b): Changes in 2-deoxyglucose transport during epididymal maturation of ram sperm. Biol Reprod 19:1030-1035.
20. Hyne RV, Edwards KP (1985): Influence of 2-deoxy-D-glucose and energy substrates on guinea-pig sperm capacitation and acrosome reaction. J Reprod Fertil 73: 59-69.
21. Kayano T, Fukumoto H, Eddy RL, Fan YS, Byers MG, Shows TB, Bell GI (1988): Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. J Biol Chem 263:15245-15248.
22. Kayano T, Burant CF, Fukumoto H, Gould GW, Fan YS, Eddy RL, Byers MG, Shows TB, Seino S, Bell GI (1990): Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). J Biol Chem 265:13276-13282.
23. Kucukkomurcu S, Delogne-Desnoeck J, Robyn C (1980): Prolactin and fructose in human seminal fluid. Int J Fertil 25:117-121.
24. Leese HJ, Astley NR, Lambert D (1981): Glucose and fructose utilization by rat spermatozoa within the uterine lumen. J Reprod Fertil 61:435-437.
25. Maher F, Simpson IA (1994): The GLUT3 glucose transporter is the predominant isoform in primary cultured neurons: Assessment by biosynthetic and photoaffinity labelling. Biochem J 301:379-384.
26. Mita M, Hall PF (1982): Metabolism of round spermatids from rats: Lactate as the preferred substrate. Biol Reprod 26:445-455.
27. Mueckler M (1994): Facilitative glucose transporters. Eur J Biochem 219:713-725.
28. Mueckler M, Caruso C, Baldwin SA, Panico M, Blench I, Morris HR, Allard WJ, Lienhard GE, Lodish HF (1985): Sequence and structure of a human glucose transporter. Science 229:941-945.
29. Nakamura M, Okinaga S, Arai K (1987): Studies of metabolism of round spermatids: Cytochalasin B binding to cell membrane in relation to glucose transport. Andrologia 19:178-182.
30. Patel SM, Skandhan KP, Mehta YB (1988): Seminal plasma fructose and glucose in normal and pathological conditions. Acta Eur Fertil 19:329-332.
31. Paz GF, Sofer A, Homonnai ZT, Kraicer PF (1977): Human semen analysis: Seminal plasma and prostatic fluid compositions and their interlations with sperm quality. Int J Fertil 22:140-147.
32. Peterson RN, Freund M (1975): Metabolism of human spermatozoa. In Ese H (ed): "Human Semen and Fertility Regulation in Men." St. Louis: Mosby, pp 552-556.
33. Peterson RN, Bundman D, Freund M (1977): Binding of cytochalasin B to hexose transport sites on human spermatozoa and inhibition of binding by purines. Biol Reprod 17:198-206.
34. Rand EB, Depaoli AM, Davidson NO, Bell GI, Burant CF (1993): Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5. Am J Physiol 264:G1169-G1176.
35. Rivas CI, Vera JC, Guaiquil VH, Veĺsquez FV, Bórquez-Qjeda O, Cárcamo JG, Concha II, Golde DW (1997): Increased uptake and accumulation of vitamin C in human immunodeficiency virus 1-infected hematopoietic cell lines. J Biol Chem 272:5814-5820.
36. Rose RC (1988): Transport of ascorbic acid and other water-soluble vitamins. Biochim Biophys Acta 947:335-366.
37. Spielholz C, Golde DW, Houghton AN, Nualart F, Vera JC (1997): Increased facilitated transport of dehydroascorbic acid without changes in sodium-dependent ascorbate transport in human melanoma cells. Cancer Res 57:2529-2537.
38. Takagi H, Tanihara H, Seino Y, Yoshimura N (1994): Characterization of glucose transporter in cultured human retinal pigment ephitelial cells: Gene expression and effect of growth factors. Invest Ophthalmol Vis Sci 35:170-177.
39. Tauber PF, Zaneveld LJ, Propping D, Schumacher GF (1975): Components of human split ejaculates. I. Spermatozoa, fructose, immunoglobulins, albumin, lactoferrin, transferrin and other plasma proteins. J Reprod Fertil 43:249-267.
40. Thorens B, Sarkar HK, Kaback HR, Lodish HF (1988): Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells. Cell 55:281-290.
41. Thorens B, Cheng ZQ, Brown D, Lodish HF (1990): Liver glucose transporter: A basolateral protein in hepatocytes and intestine and kidney cells. Am J Physiol 259:C279-C285.
42. Vera JC, Brito M, Zuvic T, Burzio LO (1984): Polypeptide composition of rat sperm outer dense fibers. J Biol Chem 259:5970-5977.
43. Vera JC, Rivas CI, Fischbarg J, Golde DW (1993): Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid. Nature 364:79-82.
44. Vera JC, Rivas CI, Zhang RH, Farber CM, Golde DW (1994): Human HL-60 myeloid leukemia cells transport dehydroascorbic acid via the glucose transporters and accumulate reduced ascorbic acid. Blood 84:1628-1634.
45. Vera JC, Rivas CI, Velásquez FV, Zhang RH, Concha II, Golde DW (1995): Resolution of the facilitated transport of dehydroascorbic acid from its reduction-dependent intracellular accumulation. J Biol Chem 270:23706-23712.
46. Vera JC, Reyes AM, Cárcamo JG, Velásquez FV, Rivas CI, Zhang RH, Strobel P, Iribarren R, Scherr HI, Slebe JC, Golde DW (1996): Genistein is a natural inhibitor of hexose and dehydroascorbic acid transport through the glucose transporter, GLUT1. J Biol Chem 271:8719-8724.
47. Waddell ID, Zomerschoe AG, Voice MW, Burchell A (1992): Cloning and expression of a hepatic microsomal glucose transport protein. Comparison with liver plasma-membrane glucose-transport protein GLUT 2. Biochem J 286: 173-177.
48. Weed JC, Carrera AE (1970): Glucose content of cervical mucus. Fertil Steril 21:866-872.