Lactadherin mediates sickle cell adhesion to vascular endothelial cells in flowing blood

Haematologica

Volumn 92, Issue 9, 2007, Pages 1266-1267

  Guchhait, Prasenjit ^a   Dasgupta, Swapan K ^a   Le, Anhquyen ^a   Yellapragada, Sarvari ^a   López, José A ^a   Thiagarajan, Perumal ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Endothelial adhesion; Lactadherin; Phosphatidyl serine; Sickle cell anemia

Indexed keywords

BINDING PROTEIN; HISTAMINE; INTEGRIN; INTEGRIN ALPHA5 BETA3; LACTADHERIN; MONOCLONAL ANTIBODY; PHOSPHATIDYLSERINE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD FLOW; CELL ADHESION; CELL STIMULATION; ENDOTHELIUM CELL; ERYTHROCYTE; HUMAN; HUMAN CELL; MACROPHAGE; PHAGOCYTOSIS; PROTEIN FUNCTION; SHEAR STRESS; SICKLE CELL; VASCULAR ENDOTHELIUM;

ANEMIA, SICKLE CELL; ANIMALS; ANTIBODIES, MONOCLONAL; CATTLE; CELL ADHESION; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTES; ERYTHROCYTES, ABNORMAL; HUMANS; INTEGRIN ALPHAVBETA3; MICE; PHAGOCYTOSIS; PHOSPHATIDYLSERINES; PROTEIN BINDING;

EID: 36348956748     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.11379     Document Type: Article

References (10)

1. Hebbel RP. Adhesive interactions of sickle erythrocytes with endothelium. J Clin Invest 1997;100:S83-6.
2. Kuypers FA, Lewis RA, Hua M, Schott MA, Discher D, Ernst JD, et al. Detection of altered membrane phospholipid asymmetry in subpopulations of human red blood cells using fluorescently labeled annexin V. Blood 1996; 87:1179-87.
3. Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature 2002;417:182-7.
4. Dasgupta SK, Thiagarajan P. The role of lactadherin in the phagocytosis of phosphatidylserine-expressing sickle red blood cells by macrophages. Haematologica 2005;90:1267-8.
5. Dasgupta SK, Guchhait P, Thiagarajan P. Lactadherin binding and phosphatidylserine expression on cell surface-comparison with annexin A5. Transl Res 2006;148:19-25.
6. Fox PC, Berenstein EH, Siraganian RP. Enhancing the frequency of antigen-specific hybridomas. Eur J Immunol 1981;11:431-4.
7. Natarajan M, Udden MM, McIntire LV. Adhesion of sickle red blood cells and damage to interleukin-1 beta stimulated endothelial cells under flow in vitro. Blood 1996; 87:4845-52.
8. de Jong K, Larkin SK, Styles LA, Bookchin RM, Kuypers FA. Characterization of the phosphatidylserine-exposing subpopulation of sickle cells. Blood 2001;98: 860-7.
9. Yasin Z, Witting S, Palascak MB, Joiner CH, Rucknagel DL, Franco RS. Phosphatidylserine externalization in sickle red blood cells: associations with cell age, density, and hemoglobin F. Blood 2003;102:365-70.
10. Ceriani RL, Sasaki M, Sussman H, Wara WM, Blank EW. Circulating human mammary epithelial antigens in breast cancer. Proc Natl Acad Sci USA 1982;79:5420-4.