The association of triple-marker test results with adverse pregnancy outcomes in low-risk pregnancies with healthy newborns

Archives of Gynecology and Obstetrics

Volumn 277, Issue 1, 2008, Pages 47-53

  Sayin, N Cenk ^a   Canda, M Tunç ^b   Ahmet, Nefize ^a   Arda, Sezer ^a   Süt, Necdet ^a   Varol, Füsun G ^a  

^a TRAKYA UNIVERSITY   (Turkey)

^b KENT HOSPITAL   (Turkey)

Author keywords

Perinatal outcome; Triple test; Turkish population

Indexed keywords

ALPHA FETOPROTEIN; BIOLOGICAL MARKER; CHORIONIC GONADOTROPIN; ESTRIOL;

ADULT; ARTICLE; CHI SQUARE TEST; CONTROLLED STUDY; CORRELATION COEFFICIENT; FEMALE; FOLLOW UP; HUMAN; MACROSOMIA; MAJOR CLINICAL STUDY; MATERNAL SERUM; OLIGOHYDRAMNIOS; PERINATAL PERIOD; PREECLAMPSIA; PREGNANCY DIABETES MELLITUS; PREGNANCY OUTCOME; PREMATURE LABOR; PROTEIN DETERMINATION; RECEIVER OPERATING CHARACTERISTIC; SAMPLE SIZE; SECOND TRIMESTER PREGNANCY; VAGINAL DELIVERY;

ADULT; ALPHA-FETOPROTEINS; BIOLOGICAL MARKERS; BIRTH WEIGHT; BODY WEIGHT; CEPHALOMETRY; CHORIONIC GONADOTROPIN; ESTRIOL; FEMALE; HUMANS; INFANT, NEWBORN; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; PREGNANCY TRIMESTER, SECOND; RETROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 36348934517     PISSN: 09320067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00404-007-0421-6     Document Type: Article

References (32)

1. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap III LC, Wenstrom KD (2005) Williams obstetrics. 22nd edn. McGraw-Hill, New York pp 313-340
2. Yaron Y, Cherry M, Kramer RL, O'Brien JE, Hallak M, Johnson MP et al (1999) Second-trimester maternal serum marker screening: maternal serum α-fetoprotein, β-human chorionic gonadotropin, estriol, and their various combinations as predictors of pregnancy outcome. Am J Obstet Gynecol 181:968-974
3. Onderoglu LS, Kabukçu A (1997) Elevated second trimester human chorionic gonadotropin level associated with adverse pregnancy outcome. Int J Gynecol Obstet 56:245-249
4. Walter DK, Lustig LS, Cunningham GC, Feuchtbaum LB, Hook EB (1996) The association between maternal serum alpha-fetoprotein and preterm birth, small for gestational age infants, preeclampsia, and placental complications. Obstet Gynecol 88:816-822
5. Stamilio DM, Sehdev HM, Morgan MA, Propert K, Macones GA (2000) Can antenatal clinical and biochemical markers predict the development of severe preeclampsia? Am J Obstet Gynecol 182:589-594
6. Walton DL, Norem CT, Schoen EJ, Ray T, Colby CJ (1999) Second-trimester serum chorionic gonadotropin concentrations and complications and outcome of pregnancy. N Engl J Med 341:2033-2036
7. Spencer K (2000) Second-trimester prenatal screening for Down syndrome and the relationship of maternal serum biochemical markers to pregnancy complications with adverse pregnancy outcome. Prenat Diagn 20:652-656
8. American Diabetes Association (2003) Position statement: gestational diabetes mellitus. Diabetes Care 26(Suppl. 1):S103-S105
9. Zweig MH, Campbell G (1993) Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39:561-577
10. Wenstrom KD, Owen J, Boots LR, Dubard MB (1994) Elevated second-trimester human chorionic gonadotropin levels in association with poor pregnancy outcome. Am J Obstet Gynecol 171:1038-1041
11. Bernstein IM, Bart RA, Miller R, Capeless EL (1992) Elevated maternal serum alpha-fetoprotein: association with placental sonolucencies, fetomaternal hemorrhage, vaginal bleeding and pregnancy outcome in the absence of fetal anomalies. Obstet Gynecol 79:71-74
12. Huerta-Enochian G, Katz W, Erfurth S (2001) The association of abnormal α-fetoprotein and adverse pregnancy outcome: does increased fetal surveillance affect pregnancy outcome? Am J Obstet Gynecol 184:1549-1553
13. Duric K, Skrablin S, Lesin J, Kalafatic D, Kuvacic I, Suchanek E (2003) Second trimester total human chorionic gonadotropin, alpha-fetoprotein and unconjugated estriol in predicting pregnancy complications other than fetal aneuploidy. Eur J Obstet Gynecol Reprod Biol 110:12-15
14. Boyd PA (1992) Why might maternal serum AFP be high in pregnancies in which the fetus is normally formed? Br J Obstet Gynaecol 99:93-95
15. KIran TSU, Bethel J, Bhal PS (2005) Correlation of abnormal second trimester maternal serum alpha-fetoprotein (MSAFP) levels and adverse pregnancy outcome. J Obstet Gynaecol 25:253-256
16. Berkeley AS, Killackey MA, Cederqvist LL (1983) Elevated maternal serum α-fetoprotein levels associated with breakdown in fetal-maternal-placental barrier. Am J Obstet Gynecol 146:859-861
17. Boyd PA, Keeling JW (1986) Raised maternal serum α-fetoprotein in the absence of fetal abnormality-placental founding: a quantitative morphometric study. Prenat Diagn 6:369-373
18. Luckas MJM, Sandland R, Hawe J, Neilson JP, McFadyen IR, Meekins JW (1998) Fetal growth retardation and second trimester maternal serum human chorionic gonadotropin levels. Placenta 19:143-147
19. Lepage N, Chitayat D, Kingdom J, Huang T (2003) Association between second-trimester isolated high maternal serum human chorionic gonadotropin levels and obstetric complications in singleton and twin pregnancies. Am J Obstet Gynecol 188:1354-1359
20. Ashour AM, Lieberman ES, Wilkins Haug LE, Repke JT (1997) The value of elevated second-trimester β-human chorionic gonadotropin in predicting development of preeclampsia. Am J Obstet Gynecol 176:438-442
21. Summers A, Huang T, Meier C, Wyatt PR (2003) The implications of a false positive second-trimester serum screen for Down syndrome. Obstet Gynecol 101:1301-1306
22. Towner D, Gandhi S, El Kady D (2006) Obstetrics outcomes in women with elevated maternal serum human chorionic gonadotropin. Am J Obstet Gynecol 194:1676-1682
23. Gonen R, Perez R, David M, Dar H, Merksamer R, Sharf M (1992) The association between unexplained second-trimester maternal serum hCG elevation and pregnancy complications. Obstet Gynecol 80:83-86
24. Liu DF, Dickerman LH, Redline RW (1999) Pathological findings in pregnancies with unexplained increases in midtrimester maternal serum human chorionic gonadotropin levels. Am J Clin Pathol 111:209-215
25. Sayin NC, Varol FG, Duran R, Acunas B, Kurt I (2007) Perinatal outcome in women screened for gestational diabetes mellitus with normal or with one elevated glucose tolerance test value. J Turkish German Gynecol Assoc 8:38-43
26. Kowalczyk TD, Cabaniss ML, Cusmano L (1998) Association of low unconjugated estriol in the second trimester and adverse pregnancy outcome. Obstet Gynecol 91:396-400
27. Kim SY, Kim SK, Lee JS, Kim IK, Lee K (2000) The prediction of adverse pregnancy outcome using low unconjugated estriol in the second trimester of pregnancy without risk of Down's syndrome. Yonsei Med J 41:226-229
28. Isouard G (1979) Measurement of serum levels of oestriol and human placental lactogen in the management of preeclamptic pregnancies. Med J Aust 2:401-404
29. Goodwin TM (1999) A role for estriol in human labor, term and preterm. Am J Obstet Gynecol 180:208-213
30. Dugoff L, Hobbins JC, Malone FD, Vidaver J, Sullivan L, Canick JA et al, for the FASTER Trial Research Consortium (2005) Quad screen as a predictor of adverse pregnancy outcome. Obstet Gynecol 106:260-267
31. Pergament E, Stein AK, Fiddler M, Cho NH, Kupferminc MJ (1995) Adverse pregnancy outcome after a false-positive screen for Down syndrome using multiple markers. Obstet Gynecol 86:255-258
32. Salafia CM, Silberman C, Herrerra NE, Mahoney MJ (1988) Placental pathology at term associated with elevated midtrimester maternal serum AFP concentration. Am J Obstet Gynecol 158:1064-1066