Brain MRI and neurological deficit measurements in focal stroke: Rapid throughput validated with isradipine

Pharmacology

Volumn 81, Issue 1, 2007, Pages 1-10

  Lenhard, Stephen C ^a   Strittmatter, Robert ^a   Price, William J ^a   Chandra, Sudeep ^c   White, Ray F ^b   Barone, Frank C ^b  

^a Centres of Excellence for Cardiovascular Urogenital Drug Discovery   (United States)

^b GLAXOSMITHKLINE   (United States)

^c PHILIPS HEALTHCARE   (United States)

Author keywords

Brain injury; Calcium channel blocker; Focal ischemia; In vivo screening; Isradipine; Middle cerebral artery occlusion; Neurological deficits; Neuroprotection; Pharmacological validation; Recovery, brain function; Serial measurements; Stroke

Indexed keywords

ISRADIPINE; TRIPHENYLTETRAZOLIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN INFARCTION; CONTROLLED STUDY; CONVALESCENCE; CORRELATION ANALYSIS; DISEASE DURATION; DOSE RESPONSE; DOSE TIME EFFECT RELATION; FORELIMB; FUNCTIONAL ASSESSMENT; HEMISPHERE; HIGH THROUGHPUT SCREENING; HINDLIMB; HISTOLOGY; IMAGE ANALYSIS; MALE; MEASUREMENT; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROIMAGING; NEUROLOGIC DISEASE; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROPRIOCEPTION; QUANTITATIVE ANALYSIS; RAT; SCORING SYSTEM; SPONTANEOUSLY HYPERTENSIVE RAT; STAINING; STANDARD; STROKE; TASK PERFORMANCE; TISSUE SECTION; VALIDATION STUDY;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN INFARCTION; CALCIUM CHANNEL BLOCKERS; DISEASE MODELS, ANIMAL; ISRADIPINE; MAGNETIC RESONANCE IMAGING; MALE; NEUROPSYCHOLOGICAL TESTS; PREDICTIVE VALUE OF TESTS; RATS; RATS, INBRED SHR; TREATMENT OUTCOME;

EID: 36249028046     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000107661     Document Type: Article

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