Cell migration patterns and ongoing somatic mutations in the progression of follicular lymphoma

Cytogenetic and Genome Research

Volumn 118, Issue 2-4, 2007, Pages 328-336

  Adam, P ^a   Schoof, J ^a   Hartmann, M ^a   Schwarz, S ^b   Puppe, B ^a   Ott, M ^a   Rosenwald, A ^a   Ott, G ^a   Muller Hermelink H K ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR ANTIGEN;

ADULT; AGED; ANTIGEN BINDING; ARTICLE; BIOPSY; CANCER GRADING; CASE REPORT; CELL MIGRATION; CELL SELECTION; CELLULAR DISTRIBUTION; CLONE; DISEASE COURSE; FEMALE; FOLLICULAR LYMPHOMA; GENE CLUSTER; GERMINAL CENTER; HUMAN; HUMAN CELL; MALE; MICROENVIRONMENT; MUTATION; PHYLOGENETIC TREE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOMATIC MUTATION; STEM CELL; TUMOR CELL; TUMOR GROWTH;

EID: 36249026568     PISSN: 14248581     EISSN: None     Source Type: Journal    
DOI: 10.1159/000108317     Document Type: Article

References (32)

1. Aarts WM, Bende RJ, Steenbergen EJ, Kluin PM, Ooms EC, et al: Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load. Blood 95:2922-2929 (2000).
2. Adam P, Katzenberger T, Eifert M, Ott MM, Rosenwald A, et al: Presence of preserved reactive germinal centers in follicular lymphoma is a strong histopathologic indicator of limited disease stage. Am J Surg Pathol 29:1661-1664 (2005).
3. Bahler DW, Levy R: Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc Natl Acad Sci USA 89:6770-6774 (1992).
4. Bakkus MH, Heirman C, Van Riet I, Van Camp B, Thielemans K: Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood 80:2326-2335 (1992).
5. Bartlett NL, Rizeq M, Dorfman RF, Halpern J, Horning SJ: Follicular large-cell lymphoma: intermediate or low grade? J Clin Oncol 12:1349-1357 (1994).
6. Bastion Y, Berger F, Bryon PA, Felman P, French M, Coiffier B: Follicular lymphomas: assessment of prognostic factors in 127 patients followed for 10 years. Ann Oncol 2 Suppl 2:123-129 (1991).
7. Campbell MJ, Zelenetz AD, Levy S, Levy R: Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire. Mol Immunol 29:193-203 (1992).
8. Cleary ML, Meeker TC, Levy S, Lee E, Trela M, Sklar J, Levy R: Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma. Cell 44:97-106 (1986).
9. Cong P, Raffeld M, Teruya-Feldstein J, Sorbara L, Pittaluga S, Jaffe ES: In situ localization of follicular lymphoma: description and analysis by laser capture microdissection. Blood 99:3376-3382 (2002).
10. Davi F, Maloum K, Michel A, Pritsch O, Magnac C, et al: High frequency of somatic mutations in the VH genes expressed in prolymphocytic leukemia. Blood 88:3953-3961 (1996).
11. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, et al: World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting - Airlie House Virginia November 1997. J Clin Oncol 17:3835-3849 (1999).
12. Horsman DE, Gascoyne R, Coupland DRW, Coldman AJ, Adomat SA: Comparison of cytogenetic analysis, Southern analysis and polymerase chain reaction for the detection of t(14; 18) in follicular lymphoma. Am J Clin Pathol 103:472-478 (1995).
13. Jacob J, Kelsoe G, Rajewsky K, Weiss U: Intraclonal generation of antibody mutants in germinal centers. Nature 354:389-392 (1991).
14. Jaffe ES, Harris NL, Stein H, Vardiman JW (eds): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues (IARC Press, Lyon 2001).
15. Kuppers R, Zhao M, Hansmann ML, Rajewsky K: Tracing B cell development in human germinal centers by molecular analysis of single cells picked from histological sections. EMBO J 12:4955-4967 (1993).
16. Matolcsy A, Casali P, Warnke RA, Knowles DM: Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene. Blood 88:3937-3944 (1996).
17. Matolcsy A, Schattner EJ, Knowles DM, Casali P: Clonal evolution of B cells in transformation from low- to high-grade lymphoma. Eur J Immunol 29:1253-1264 (1999).
18. Miller TP, LeBlanc M, Grogan TM, Fisher RI: Follicular lymphomas: do histologic subtypes predict outcome? Hematol Oncol Clin North Am 11:893-900 (1997).
19. Muller-Hermelink HK, Zettl A, Pfeifer W, Ott G: Pathology of lymphoma progression. Histopathology 38:285-306 (2001).
20. Noppe SM, Heirman C, Bakkus MH, Brissinck J, Schots R, Thielemans K: The genetic variability of the VH genes in follicular lymphoma: the impact of the hypermutation mechanism. Br J Haematol 107:625-640 (1999).
21. Oeschger S, Brauninger A, Kuppers R, Hansmann ML: Tumor cell dissemination in follicular lymphoma. Blood 99:2192-2198 (2002).
22. Ottensmeier CH, Thompsett AR, Zhu D, Wilkins BS, Sweetenham JW, Stevenson FK: Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression. Blood 91:4292-4299 (1998).
23. Rowley JD: Chromosome studies in the non-Hodgkin's lymphomas: the role of the 14; 18 translocation. J Clin Oncol 6:919-925 (1988).
24. Sanchez-Beato M, Sanchez-Aguilera A, Piris MA: Cell cycle deregulation in B-cell lymphomas. Blood 101:1220-1235 (2003).
25. Sander CA, Yano T, Clark HM, Harris C, Longo DL, et al: p53 mutation is associated with progression in follicular lymphomas. Blood 82:1994-2004 (1993).
26. Su W, Spencer J, Wotherspoon AC: Relative distribution of tumour cells and reactive cells in follicular lymphoma. J Pathol 193:498-504 (2001).
27. Vescio RA, Cao J, Hong CH, Lee JC, Wu CH, et al: Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity. J Immunol 155:2487-2497 (1995),
28. Yahalom J: Radiation therapy in the treatment of lymphoma. Curr Opin Oncol 11:370-374 (1999).
29. Yano T, Jaffe ES, Longo DL, Raffeld M: MYC rearrangements in histologically progressed follicular lymphomas. Blood 80:758-767 (1992).
30. Zelenetz AD, Chen TT, Levy R: Histologic transformation of follicular lymphoma to diffuse lymphoma represents tumor progression by a single malignant B cell. J Exp Med 173:197-207 (1991).
31. Zhu D, Hawkins RE, Hamblin TJ, Stevenson FK: Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes. Br J Haematol 86:505-512 (1994).
32. Ziegner M, Steinhauser G, Berek C: Development of antibody diversity in single germinal centers: selective expansion of high-affinity variants. Eur J Immunol 24:2393-2400 (1994).