Mu opioid receptor mutant, T394A, abolishes opioid-mediated adenylyl cyclase superactivation

NeuroReport

Volumn 18, Issue 18, 2007, Pages 1969-1973

  Wang, Hongyan ^a,b   Guang, Wei ^a   Barbier, Elisabeth ^a   Shapiro, Paul ^a   Wang, Jia Bei ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Adenylyl cyclase superactivation; Chronic opioid treatment; Mu opioid receptor; Pointmutation; Receptor phosphorylation

Indexed keywords

ADENYLATE CYCLASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MU OPIATE RECEPTOR; MUTANT PROTEIN;

ADAPTIVE BEHAVIOR; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; AMINO ACID SEQUENCE; ANALGESICS, OPIOID; ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENZYME ACTIVATION; MAP KINASE KINASE 1; PHOSPHORYLATION; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, OPIOID, MU; SUBCELLULAR FRACTIONS;

EID: 36249000516     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e3282f228b2     Document Type: Article

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