Is codon 129 of prion protein polymorphic in human beings but not in animals?

Lancet

Volumn 349, Issue 9065, 1997, Pages 1603-1604

  Schätzl, Hermann M ^a   Wopfner, Franziska ^b   Gilch, Sabine ^b   Von Brunn, Albrecht ^b   Jäger, Gundula ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; METHIONINE; PRION PROTEIN; VALINE;

ARTICLE; BOVINE SPONGIFORM ENCEPHALOPATHY; CATTLE; CODON; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DISEASE PREDISPOSITION; GENE FREQUENCY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; PROTEIN STRUCTURE; SPECIES DIFFERENCE;

EID: 0343923634     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)61632-7     Document Type: Article

References (5)

1. Palmer MS, Dryden AJ, Hughes JT, et al. Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jacob disease. Nature 1991; 352: 340-42.
2. Will RG, Ironside JW, Zeidler M, et al. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 1996; 347: 921-25.
3. Riek R, Hornemann S, Wider G, Billeter M, Glockshuber R, Wüthrich K. NMR structure of the mouse protein domain PrP (121-231). Nature 1996; 382: 180-82.
4. Schätzl HM, Da Costa M, Taylor L, Cohen FE, Prusiner SB. Prion protein gene variation among primates. J Mol Biol 1995; 245: 362-74.
5. Williams ES, Young S. Chronic wasting disease of captive mule deer: a spongiform encephalopathy. J Wildl Dis 1980; 16: 89-98.