Trapping of adrenergic decongestant drugs into cellular endomembrane compartments: Toxicological and pharmacological consequences

International Immunopharmacology

Volumn 7, Issue 14, 2007, Pages 1869-1879

  Morissette, Guillaume ^a,b   Bouthillier, Johanne ^a,b   Marceau, François ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

Phenylephrine; Rabbit aorta; Rhinitis medicamentosa; Vacuolar ATPase; Xylometazoline

Indexed keywords

ADRENALIN; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BAFILOMYCIN A1; DECONGESTIVE AGENT; MYDRIATIC AGENT; NORMETADRENALIN; PHENYLEPHRINE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; XYLOMETAZOLINE;

ANIMAL CELL; AORTA MEDIA; ARTICLE; CELL MEMBRANE; CELL VACUOLE; CONTROLLED STUDY; CYTOPATHOLOGY; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG MECHANISM; NONHUMAN; PRIORITY JOURNAL; RABBIT; RHINITIS; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; TREATMENT DURATION;

EID: 36248933734     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2007.07.001     Document Type: Article

References (28)

1. Wenzel S., Sagowski C., Laux G., Kehrl W., and Metternich F.U. Course and therapy of intoxication with imidazoline derivate naphazoline. Int J Pediatr Otorhinolaryngol 68 (2004) 979-983
2. Kumar V.V., Gaughan J., Isaacson G., and Szeremeta W. Oxymetazoline is equivalent to ciprofloxacin in preventing postoperative otorrhea or tympanostomy tube obstruction. Laryngoscope 115 (2005) 363-365
3. Graf P. Rhinitis medicamentosa: a review of causes and treatment. Treat Respir Med 4 (2005) 21-29
4. Suh S.H., Chon K.M., Min Y.G., Jeong C.H., and Hong S.H. Effects of topical nasal decongestants on histology of nasal respiratory mucosa in rabbits. Acta Otolaryngol 115 (1995) 664-671
5. Min Y.G., Kim H.S., Suh S.H., Jeon S.Y., Son Y.I., and Yoon S. Paranasal sinusitis after long-term use of topical nasal decongestants. Acta Otolaryngol 116 (1996) 465-471
6. Cohen K.L., Van Horn D.L., Edelhauser H.F., and Schultz R.O. Effect of phenylephrine on normal and regenerated endothelial cells in cat cornea. Invest Ophthalmol Vis Sci 18 (1979) 242-249
7. Edelhauser H.F., Hine J.E., Pederson H., Van Horn D.L., and Schultz R.O. The effect of phenylephrine on the cornea. Arch Ophthalmol 97 (1997) 937-947
8. Kawasaki-Nishi S., Nishi T., and Forgac M. Proton translocation driven by ATP hydrolysis in V-ATPases. FEBS Lett 545 (2003) 76-85
9. Moriyama Y. Membrane energization by proton pumps is important for compartmentalization of drugs and toxins: a new type of active transport. J Exp Biol 199 (1996) 1447-1454
10. Morissette G., Moreau E., C-Gaudreault R., and Marceau F. Massive cell vacuolization induced by organic amines such as procainamide. J Pharmacol Exp Ther 310 (2004) 395-406
11. Morissette G., Moreau E., C-Gaudreault R., and Marceau F. N-substituted 4-aminobenzamides (procainamide analogs): an assessment of multiple cellular effects concerning ion trapping. Mol Pharmacol 68 (2005) 1576-1589
12. Morissette G., Germain L., and Marceau F. The anti-wrinkle effect of topical concentrated 2-dimethylaminoethanol involves a vacuolar cytopathology. Br J Dermatol 156 (2007) 433-439
13. Murphy M.P., and Smith R.A.J. Drug delivery to mitochondria: the key to mitochondrial medicine. Adv Drug Deliv Rev 41 (2000) 235-250
14. Modica-Napolitano J.S., and Aprille J.R. Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells. Adv Drug Deliv Rev 49 (2001) 63-70
15. Weiss M.J., Wong J.R., Ha C.S., Bleday R., Salem R.R., Steele Jr. G.D., et al. Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial accumulation. Proc Natl Acad Sci U S A 84 (1987) 5444-5448
16. Hofman B.B. Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists. In: Hardman J.G., Limbird L.E., and Gilman A.G. (Eds). Goodman and Gilman's the pharmacologic basis of therapeutics (2001), McGraw-Hill, New York 215-268
17. Bhavsar V.H., Joshi N.J., Kelkar V.V., and Patel M.P. Effect of guanethidine on alpha-adrenoceptor blocking potency of phentolamine in vitro. Eur J Pharmacol 67 (1980) 489-492
18. Grouselle M., Tueux O., Dabadie P., Georgescaud D., and Mazat J.P. Effect of local anaesthetics on mitochondrial membrane potential in living cells. Biochem J 271 (1990) 269-272
19. 1 receptors induced by tissue injury. J Immunol 160 (1998) 1419-1426
20. Hayer-Zillgen M., Brüss M., and Bönisch H. Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol 136 (2002) 829-836
21. Siebert G.A., Hung D.Y., Chang P., and Roberts M.S. Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs. J Pharmacol Exp Ther 308 (2004) 228-235
22. 2+ release is inhibited by mitochondrial depolarization. Biochem J 347 (2000) 593-600
23. Negibil C., and Malik K.U. Prostaglandin synthesis elicited by adrenergic stimuli is mediated via alpha-2C and alpha-1A adrenergic receptors in cultured smooth muscle cells of rabbit aorta. J Pharmacol Exp Ther 260 (1992) 848-858
24. Horvath G., Torbati A., Conner G.E., Salathe M., and Wanner A. Systemic ovalbumin sensitization downregulates norepinephrine uptake by rabbit aortic smooth muscle cells. Am J Respir Cell Mol Biol 27 (2002) 747-751
25. Tse W.C., and Boger D.L. Sequence-selective DNA recognition: natural products and nature's lessons. Chem Biol 11 (2004) 1607-1617
26. Kenakin T.P. Concentration of drugs in tissues. Pharmacological analysis of drug-receptor interaction (1987), Raven Press, New York 99-128
27. 2+ signalling mechanism and plays a different physiological role. Mol Pharmacol 38 (1990) 725-736
28. 1-Adrenoceptor subtypes and two receptor systems in vascular tissues. Life Sci 62 (1998) 1461-1465