Dual role for Zn2+ in maintaining structural integrity and inducing DNA sequence specificity in a promiscuous endonuclease

Journal of Biological Chemistry

Volumn 282, Issue 44, 2007, Pages 32320-32326

  Saravanan, Matheshwaran ^a   Vasu, Kommireddy ^a   Ghosh, Soumitra ^a   Nagaraja, Valakunja ^a,b  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; CATALYST ACTIVITY; DNA; ENZYME ACTIVITY; PROTEINS;

DNA SEQUENCE; STRUCTURAL SCAFFOLD; ZINC BINDING;

ZINC;

CALCIUM ION; DNA; MAGNESIUM ION; MANGANESE; METAL ION; RESTRICTION ENDONUCLEASE; ZINC ION; DEOXYRIBONUCLEASE; ENDODEOXYRIBONUCLEASE KPNI; ENDODEOXYRIBONUCLEASE VII; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE; UNCLASSIFIED DRUG; ZINC; ZINC FINGER PROTEIN;

ARTICLE; ATOM; CALCIUM BINDING; CATALYSIS; DNA BINDING; DNA CLEAVAGE; DNA SEQUENCE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME STRUCTURE; METAL BINDING; PRIORITY JOURNAL; PROKARYOTE; PROTEIN FUNCTION; PROTEIN MOTIF; ZINC FINGER MOTIF; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION;

PROKARYOTA;

AMINO ACID SEQUENCE; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA; ENDODEOXYRIBONUCLEASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; ZINC; ZINC FINGERS;

EID: 36148984593     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M705927200     Document Type: Article

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