Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation

Biological Research

Volumn 40, Issue 2, 2007, Pages 155-162

  López Alarcón, Camilo ^a   Speisky, Hernán ^b   Lissi, Eduardo ^c  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c UNIVERSIDAD DE SANTIAGO DE CHILE   (Chile)

Author keywords

5 Aminosalicylic acid; Antioxidant; LDL oxidation

Indexed keywords

AMINOSALICYLIC ACID; COPPER SULFATE; LOW DENSITY LIPOPROTEIN; TROLOX C; WATER;

ABSORPTION; ACCELERATION; ANTIOXIDANT ACTIVITY; ARTICLE; BINDING KINETICS; CHELATION; CHEMOLUMINESCENCE; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG STRUCTURE; HUMAN; LIPID PEROXIDATION; ULTRAVIOLET SPECTROSCOPY;

EID: 36148977937     PISSN: 07169760     EISSN: 07176287     Source Type: Journal    
DOI: 10.4067/S0716-97602007000200006     Document Type: Article

References (16)

1. AUMAIS G, LEFEBVRE M, TREMBLAY C, BITTON A, MARTIN F, GIARD A, MADI M, SPENARD J (2003) Rectal tissue, plasma and urine concentrations of mesalazine after single and multiple administrations of 500 mg suppositories to healthy volunteers and ulcerative proctitis patients. Aliment Pharmacol Ther 17: 93-97
2. BEHRENS W, THOMPSON J, MADERE R (1982) Distribution of alpha-tocopherol in human plasma lipoproteins. Am J Clin Nutr 35: 691-696
3. BROWN J, KHODR H, HIDER R, RICE-EVANS C (1998) Structural dependence of flavonoid interactions with Cu 2+ ions: implications for their antioxidant properties. Biochem J 330: 1173-1178
4. CONNER E, BRAND S, DAVIS J, KANG D, GRISHAM M (1996) Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease: toxins, mediators, and modulators of gene expression. Inflamm Bowel Dis 2: 133-147
5. DINIS T, MADEIRA V, ALMEIDA L (1994) Action of phenolic derivatives (acetaminophen, salycilate and 5-aminosalycilate) as inhibitors of membrane lipid peroxidation as peroxyl radicals scavengers. Arch Biochem Biophys 315: 161-169
6. GIESEG S, ESTERBAUER H (1994) Low density lipoprotein is saturable by pro-oxidant copper. FEBS Lett 343: 188-194.
7. GONÇALVES E, ALMEIDA L, DINIS T (1998a) Antioxidant activity of 5-ASA against lipid peroxidation in the presence of vitamin C and E. Int J Pharm 172: 219-228
8. GONÇALVES E, ALMEIDA L, DINIS T (1998b) Antioxidant activity of 5-aminosalicylic acid against peroxidation of phosphatidylcholine liposomes in the presence of alpha-tocopherol: a synergistic interaction? Free Radic Res 29: 53-66
9. GRISHAM M, WARE K, MARSHALL S, YAMADA T, SANDHU I (1992) Prooxidant properties of 5-aminosalicylic acid. Possible mechanism for its adverse side effects. Dig Dis Sci 37: 1383-1389
10. HANAUER S, PRESENT D (2003) The state of the art in the management of inflammatory bowel disease. Rev Gastroenterol Disord 3: 81-92
11. HOTZER K, HENRÍQUEZ C, PINO E, MIRANDA-ROTTMANN S, ASPILLAGA A, LEIGHTON F, LISSI E (2005) Antioxidant and pro-oxidant effects of red wine and its fractions on Cu(II) induced LDL oxidation evaluated by absorbance and chemiluminescence measurements. Free Radic Res 39: 175-183
12. KANSKI J, LAUDERBACK C, BUTTERFIELD D (2001) 5-aminosalycilic acid protection against oxidative damage to synaptosomal membranes by alkoxyl radicals in vitro. Neurochem Res 26: 23-29
13. LISSI E, CÁCERES T, VIDELA L (1988) Visible chemiluminescence from rat brain homogenates undergoing autoxidation. II. Kinetics of the luminescence decay. Free Radic Biol Med 4: 93-97
14. PEARSON D, JOURD'HEUIL D, MEDDINGS J (1996) The antioxidant properties of 5- aminosalicylic acid. Free Radic Biol Med 21: 367-373
15. ROSS R (1993) The pathogenesis of atherosclerosis a perpective for the 1990s. Nature 362: 801-809
16. WIDLANSKY M, DUFFY S, HAMBURG N, GOKCE N, WARDEN B, WISEMAN S, KEANEY J, FREI B, VITA J (2005) Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease Free Radic Biol Med 38: 499-506