Orally-administered caspase inhibitor DF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against α-Fas-induced liver injury in a mouse model

Journal of Pharmacological Sciences

Volumn 105, Issue 2, 2007, Pages 201-205

  Ueno, Yoshinobu ^a   Ohmi, Takashi ^a   Yamamoto, Mitsuko ^a   Kato, Naoto ^a   Moriguchi, Yukiko ^a   Kojima, Midori ^a   Shimozono, Rieko ^a   Suzuki, Sachiko ^b   Matsuura, Tomomi ^b   Eda, Hiroyuki ^a  

^a Pfizer Japan Inc   (Japan)

^b PFIZER INC   (United States)

Author keywords

Alanine aminotransferase (ALT); Caspase; Fas

Indexed keywords

3 [2 [(2 TERT BUTYLPHENYLAMINOOXALYL)AMINO]PROPIONYLAMINO] 4 OXO 5 (2,3,5,6 TETRAFLUOROPHENOXY)PENTANOIC ACID; ALANINE AMINOTRANSFERASE; CASPASE INHIBITOR; FAS ANTIGEN; PF 03491390; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BAGG ALBINO MOUSE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN;

EID: 36148975666     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.SC0070207     Document Type: Article

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