"Mismatch" in regional myocardial perfusion defects during exercise and pharmacologic vasodilation: A noninvasive marker of epicardial vasomotor dysfunction?

Journal of Nuclear Cardiology

Volumn 14, Issue 6, 2007, Pages 769-774

  Schindler, Thomas H ^a,b   Schelbert, Heinrich H ^b  

^a Department of Internal Medicine   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; AMMONIA; DIPYRIDAMOLE; NITROGEN 13; TETROFOSMIN TC 99M; THALLIUM 201;

CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CONSTRICTION; CORONARY ARTERY DISEASE; CORONARY ARTERY OBSTRUCTION; DIAGNOSTIC ACCURACY; EDITORIAL; ELECTROCARDIOGRAPHY; ENDOTHELIAL DYSFUNCTION; EPICARDIUM; EXERCISE TEST; HEART MUSCLE PERFUSION; HUMAN; MULTIDETECTOR COMPUTED TOMOGRAPHY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMOOTH MUSCLE RELAXATION; ST SEGMENT DEPRESSION; VASODILATATION; VASOMOTOR DISORDER;

EXERCISE TEST; PERICARDIUM; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; VASODILATOR AGENTS; VASOMOTOR SYSTEM; VENTRICULAR DYSFUNCTION, LEFT;

EID: 36148954714     PISSN: 10713581     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nuclcard.2007.09.009     Document Type: Editorial

References (72)

1. Verna E., Ceriani L., Provasoli S., Scotti S., and Ghiringhelli S. Larger perfusion defects with exercise compared with dipyridamole SPECT (exercise-dipyridamole mismatch) may reflect differences in epicardial and microvascular coronary dysfunction: when the stressor matters. J Nucl Cardiol 14 (2007) 818-826
2. Zeiher A.M., Krause T., Schachinger V., Minners J., and Moser E. Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia. Circulation 91 (1995) 2345-2352
3. Gould K.L. Assessing progression or regression of CAD: the role of perfusion imaging. J Nucl Cardiol 12 (2005) 625-638
4. Schachinger V., and Zeiher A.M. Prognostic implications of endothelial dysfunction: does it mean anything?. Coron Artery Dis 12 (2001) 435-443
5. Gould K.L., Nakagawa Y., Nakagawa K., Sdringola S., Hess M.J., Haynie M., et al. Frequency and clinical implications of fluid dynamically significant diffuse coronary artery disease manifest as graded, longitudinal, base-to-apex myocardial perfusion abnormalities by noninvasive positron emission tomography. Circulation 101 (2000) 1931-1939
6. Sdringola S., Loghin C., Boccalandro F., and Gould K.L. Mechanisms of progression and regression of coronary artery disease by PET related to treatment intensity and clinical events at long-term follow-up. J Nucl Med 47 (2006) 59-67
7. Zeiher A.M., Drexler H., Wollschlaeger H., Saurbier B., and Just H. Coronary vasomotion in response to sympathetic stimulation in humans: importance of the functional integrity of the endothelium. J Am Coll Cardiol 14 (1989) 1181-1190
8. Zeiher A.M., Drexler H., Wollschlager H., and Just H. Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis. Circulation 84 (1991) 1984-1992
9. Zeiher A.M., Drexler H., Wollschlager H., and Just H. Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 83 (1991) 391-401
10. Buus N.H., Bottcher M., Hermansen F., Sander M., Nielsen T.T., and Mulvany M.J. Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia. Circulation 104 (2001) 2305-2310
11. Tawakol A., Forgione M.A., Stuehlinger M., Alpert N.M., Cooke J.P., Loscalzo J., et al. Homocysteine impairs coronary microvascular dilator function in humans. J Am Coll Cardiol 40 (2002) 1051-1058
12. Camici P.G., and Crea F. Coronary microvascular dysfunction. N Engl J Med 356 (2007) 830-840
13. Hernandez-Pampaloni M., Keng F.Y., Kudo T., Sayre J.S., and Schelbert H.R. Abnormal longitudinal, base-to-apex myocardial perfusion gradient by quantitative blood flow measurements in patients with coronary risk factors. Circulation 104 (2001) 527-532
14. Schindler T.H., Facta A.D., Prior J.O., Campisi R., Inubushi M., Kreissl M.C., et al. PET-measured heterogeneity in longitudinal myocardial blood flow in response to sympathetic and pharmacologic stress as a non-invasive probe of epicardial vasomotor dysfunction. Eur J Nucl Med Mol Imaging 33 (2006) 1140-1149
15. De Bruyne B., Hersbach F., Pijls N.H., Bartunek J., Bech J.W., Heyndrickx G.R., et al. Abnormal epicardial coronary resistance in patients with diffuse atherosclerosis but "normal" coronary angiography. Circulation 104 (2001) 2401-2406
16. Lim M.J., and Kern M.J. Coronary pathophysiology in the cardiac catheterization laboratory. Curr Probl Cardiol 31 (2006) 493-550
17. Gould K.L., Lipscomb K., and Calvert C. Compensatory changes of the distal coronary vascular bed during progressive coronary constriction. Circulation 51 (1975) 1085-1094
18. Drexler H., Zeiher A.M., Wollschlager H., Meinertz T., Just H., and Bonzel T. Flow-dependent coronary artery dilatation in humans. Circulation 80 (1989) 466-474
19. Cox D.A., Vita J.A., Treasure C.B., Fish R.D., Alexander R.W., Ganz P., et al. Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans. Circulation 80 (1989) 458-465
20. Zeiher A.M., and Drexler H. Coronary hemodynamic determinants of epicardial artery vasomotor responses during sympathetic stimulation in humans. Basic Res Cardiol 86 Suppl 2 (1991) 203-213
21. Johnson N.P., and Gould K.L. Clinical evaluation of a new concept: resting myocardial perfusion heterogeneity quantified by Markovian analysis of PET identifies coronary microvascular dysfunction and early atherosclerosis in 1,034 subjects. J Nucl Med 46 (2005) 1427-1437
22. Zeiher A.M., Schachlinger V., Hohnloser S.H., Saurbier B., and Just H. Coronary atherosclerotic wall thickening and vascular reactivity in humans. Elevated high-density lipoprotein levels ameliorate abnormal vasoconstriction in early atherosclerosis. Circulation 89 (1994) 2525-2532
23. Hess O.M., Buchi M., Kirkeeide R., Niederer P., Anliker M., Gould K.L., et al. Potential role of coronary vasoconstriction in ischaemic heart disease: effect of exercise. Eur Heart J 11 Suppl B (1990) 58-64
24. Kaufmann P., Mandinov L., and Hess O.M. Coronary stenosis vasoconstriction: impact on myocardial ischaemia. Eur Heart J 18 (1997) 1853-1859
25. Kaufmann P., Vassalli G., Utzinger U., and Hess O.M. Coronary vasomotion during dynamic exercise: influence of intravenous and intracoronary nicardipine. J Am Coll Cardiol 26 (1995) 624-631
26. Kaufmann P.A., Frielingsdorf J., Mandinov L., Seiler C., Hug R., and Hess O.M. Reversal of abnormal coronary vasomotion by calcium antagonists in patients with hypercholesterolemia. Circulation 97 (1998) 1348-1354
27. Chow B.J., Beanlands R.S., Lee A., DaSilva J.N., deKemp R.A., Alkahtani A., et al. Treadmill exercise produces larger perfusion defects than dipyridamole stress N-13 ammonia positron emission tomography. J Am Coll Cardiol 47 (2006) 411-416
28. Abe S., Takeishi Y., Chiba J., Ikeda K., and Tomoike H. Comparison of adenosine and treadmill exercise thallium-201 stress tests for the detection of coronary artery disease. Jpn Circ J 57 (1993) 1111-1119
29. David N., Marie P.Y., Angioi M., Rodriguez R.M., Hassan N., Olivier P., et al. Dipyridamole and exercise SPET provide different estimates of myocardial ischaemic areas: role of the severity of coronary stenoses and of the increase in heart rate during exercise. Eur J Nucl Med 27 (2000) 788-799
30. Iskandrian A.S. Single-photon emission computed tomographic thallium imaging with adenosine, dipyridamole, and exercise. Am Heart J 122 Pt 1 (1991) 279-284
31. Levine M.G., Ahlberg A.W., Mann A., White M.P., McGill C.C., Mendes de Leon C., et al. Comparison of exercise, dipyridamole, adenosine, and dobutamine stress with the use of Tc-99m tetrofosmin tomographic imaging. J Nucl Cardiol 6 (1999) 389-396
32. Victor R.G., Leimbach Jr. W.N., Seals D.R., Wallin B.G., and Mark A.L. Effects of the cold pressor test on muscle sympathetic nerve activity in humans. Hypertension 9 (1987) 429-436
33. Britten M.B., Zeiher A.M., and Schachinger V. Microvascular dysfunction in angiographically normal or mildly diseased coronary arteries predicts adverse cardiovascular long-term outcome. Coron Artery Dis 15 (2004) 259-264
34. Schachinger V., Britten M.B., and Zeiher A.M. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101 (2000) 1899-1906
35. Gordon J.B., Ganz P., Nabel E.G., Fish R.D., Zebede J., Mudge G.H., et al. Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise. J Clin Invest 83 (1989) 1946-1952
36. Ludmer P.L., Selwyn A.P., Shook T.L., Wayne R.R., Mudge G.H., Alexander R.W., et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 315 (1986) 1046-1051
37. Hasdai D., Gibbons R.J., Holmes Jr. D.R., Higano S.T., and Lerman A. Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects. Circulation 96 (1997) 3390-3395
38. Lerman A., and Zeiher A.M. Endothelial function: cardiac events. Circulation 111 (2005) 363-368
39. Schindler T.H., Hornig B., Buser P.T., Olschewski M., Magosaki N., Pfisterer M., et al. Prognostic value of abnormal vasoreactivity of epicardial coronary arteries to sympathetic stimulation in patients with normal coronary angiograms. Arterioscler Thromb Vasc Biol 23 (2003) 495-501
40. Schindler T.H., Nitzsche E.U., Schelbert H.R., Olschewski M., Sayre J., Mix M., et al. Positron emission tomography-measured abnormal responses of myocardial blood flow to sympathetic stimulation are associated with the risk of developing cardiovascular events. J Am Coll Cardiol 45 (2005) 1505-1512
41. Hachamovitch R., Berman D.S., Shaw L.J., Kiat H., Cohen I., Cabico J.A., et al. Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: differential stratification for risk of cardiac death and myocardial infarction. Circulation 97 (1998) 535-543
42. Chan S.Y., Mancini G.B., Kuramoto L., Schulzer M., Frohlich J., and Ignaszewski A. The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery disease. J Am Coll Cardiol 42 (2003) 1037-1043
43. Nishimura S., Mahmarian J.J., Boyce T.M., and Verani M.S. Equivalence between adenosine and exercise thallium-201 myocardial tomography: a multicenter, prospective, crossover trial. J Am Coll Cardiol 20 (1992) 265-275
44. Berman D.S., Kang X., Nishina H., Slomka P.J., Shaw L.J., Hayes S.W., et al. Diagnostic accuracy of gated Tc-99m sestamibi stress myocardial perfusion SPECT with combined supine and prone acquisitions to detect coronary artery disease in obese and nonobese patients. J Nucl Cardiol 13 (2006) 191-201
45. Di Carli M.F., and Hachamovitch R. New technology for noninvasive evaluation of coronary artery disease. Circulation 115 (2007) 1464-1480
46. Hachamovitch R., Hayes S.W., Friedman J.D., Cohen I., and Berman D.S. Stress myocardial perfusion single-photon emission computed tomography is clinically effective and cost effective in risk stratification of patients with a high likelihood of coronary artery disease (CAD) but no known CAD. J Am Coll Cardiol 43 (2004) 200-208
47. Hachamovitch R., Hayes S.W., Friedman J.D., Cohen I., and Berman D.S. A prognostic score for prediction of cardiac mortality risk after adenosine stress myocardial perfusion scintigraphy. J Am Coll Cardiol 45 (2005) 722-729
48. Kang X., Berman D.S., Lewin H., Miranda R., Erel J., Friedman J.D., et al. Comparative ability of myocardial perfusion single-photon emission computed tomography to detect coronary artery disease in patients with and without diabetes mellitus. Am Heart J 137 (1999) 949-957
49. Gupta N.C., Esterbrooks D.J., Hilleman D.E., and Mohiuddin S.M. Comparison of adenosine and exercise thallium-201 single-photon emission computed tomography (SPECT) myocardial perfusion imaging. The GE SPECT Multicenter Adenosine Study Group. J Am Coll Cardiol 19 (1992) 248-257
50. Berman D.S., Salel A.F., DeNardo G.L., and Mason D.T. Noninvasive detection of regional myocardial ischemia using rubidium-81 and the scintillation camera: comparison with stress electrocardiography in patients with arteriographically documented coronary stenosis. Circulation 52 (1975) 619-626
51. Kwok Y., Kim C., Grady D., Segal M., and Redberg R. Meta-analysis of exercise testing to detect coronary artery disease in women. J Am Coll Cardiol 83 (1999) 660-666
52. Weiner D.A., Ryan T.J., McCabe C.H., Kennedy J.W., Schloss M., Tristani F., et al. Exercise stress testing. Correlations among history of angina, ST-segment response and prevalence of coronary-artery disease in the Coronary Artery Surgery Study (CASS). N Engl J Med 301 (1979) 230-235
53. Detry J.M., Kapita B.M., Cosyns J., Sottiaux B., Brasseur L.A., and Rousseau M.F. Diagnostic value of history and maximal exercise electrocardiography in men and women suspected of coronary heart disease. Circulation 56 (1977) 756-761
54. Sketch M.H., Mohiuddin S.M., Lynch J.D., Zencka A.E., and Runco V. Significant sex differences in the correlation of electrocardiographic exercise testing and coronary arteriograms. J Am Coll Cardiol 36 (1975) 169-173
55. Beller G.A. CT angiography: too much too soon?. J Nucl Cardiol 14 (2007) 267-268
56. Cury R.C., Nieman K., Shapiro M.D., Nasir K., Cury R.C., and Brady T.J. Comprehensive cardiac CT study: evaluation of coronary arteries, left ventricular function, and myocardial perfusion-is it possible?. J Nucl Cardiol 14 (2007) 229-243
57. Thomas G.S. Coronary computed tomographic angiography: competitive or complementary?. J Nucl Cardiol 13 (2006) 605-608
58. Di Carli M.F., Dorbala S., and Hachamovitch R. Integrated cardiac PET-CT for the diagnosis and management of CAD. J Nucl Cardiol 13 (2006) 139-144
59. Di Carli M.F. CT coronary angiography: where does it fit?. J Nucl Med 47 (2006) 1397-1399
60. Hoffmann U., Ferencik M., Cury R.C., and Pena A.J. Coronary CT angiography. J Nucl Med 47 (2006) 797-806
61. Einstein A.J., Henzlova M.J., and Rajagopalan S. Estimating risk of cancer associated with radiation exposure from 64-slice computed tomography coronary angiography. JAMA 298 (2007) 317-323
62. Trabold T., Buchgeister M., Kuttner A., Heuschmid M., Kopp A.F., Schroder S., et al. Estimation of radiation exposure in 16-detector row computed tomography of the heart with retrospective ECG-gating. Rofo 175 (2003) 1051-1055
63. Leschka S., Scheffel H., Desbiolles L., Plass A., Gaemperli O., Valenta I., et al. Image quality and reconstruction intervals of dual-source CT coronary angiography: recommendations for ECG-pulsing windowing. Invest Radiol 42 (2007) 543-549
64. Gaemperli O., Schepis T., Kalff V., Namdar M., Valenta I., Stefani L., et al. Validation of a new cardiac image fusion software for three-dimensional integration of myocardial perfusion SPECT and stand-alone 64-slice CT angiography. Eur J Nucl Med Mol Imaging 34 (2007) 1097-1106
65. Gaemperli O., Schepis T., Valenta I., Husmann L., Scheffel H., Duerst V., et al. Cardiac image fusion from stand-alone SPECT and CT: clinical experience. J Nucl Med 48 (2007) 696-703
66. Gaemperli O., Schepis T., Koepfli P., Valenta I., Soyka J., Leschka S., et al. Accuracy of 64-slice CT angiography for the detection of functionally relevant coronary stenoses as assessed with myocardial perfusion SPECT. Eur J Nucl Med Mol Imaging 34 (2007) 1162-1171
67. Di Carli M.F., Dorbala S., Meserve J., El Fakhri G., Sitek A., and Moore S.C. Clinical myocardial perfusion PET/CT. J Nucl Med 48 (2007) 783-793
68. Rozanski A., Gransar H., Wong N.D., Shaw L.J., Miranda-Peats R., Polk D., et al. Clinical outcomes after both coronary calcium scanning and exercise myocardial perfusion scintigraphy. J Am Coll Cardiol 49 (2007) 1352-1361
69. Budoff M.J., Shaw L.J., Liu S.T., Weinstein S.R., Mosler T.P., Tseng P.H., et al. Long-term prognosis associated with coronary calcification: observations from a registry of 25,253 patients. J Am Coll Cardiol 49 (2007) 1860-1870
70. Ganz P., and Vita J.A. Testing endothelial vasomotor function: nitric oxide, a multipotent molecule. Circulation 108 (2003) 2049-2053
71. Widlansky M.E., Gokce N., Keaney Jr. J.F., and Vita J.A. The clinical implications of endothelial dysfunction. J Am Coll Cardiol 42 (2003) 1149-1160
72. Bonetti P.O., Lerman L.O., and Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 23 (2003) 168-175