Larger perfusion defects with exercise compared with dipyridamole SPECT (exercise-dipyridamole mismatch) may reflect differences in epicardial and microvascular coronary dysfunction: When the stressor matters

Journal of Nuclear Cardiology

Volumn 14, Issue 6, 2007, Pages 818-826

  Verna, Edoardo ^a   Ceriani, Luca ^b   Provasoli, Stefano ^a   Scotti, Simone ^a   Ghiringhelli, Sergio ^a  

^a OSPEDALE DI CIRCOLO   (Italy)

^b REGIONAL HOSPITAL OF LUGANO   (Switzerland)

Author keywords

Coronary artery disease; endothelial dysfunction; exercise stress testing; myocardial perfusion imaging; pharmacologic stress

Indexed keywords

ACETYLCHOLINE; ADENOSINE; DIPYRIDAMOLE; GLYCERYL TRINITRATE; TETROFOSMIN TC 99M; VASODILATOR AGENT;

ADULT; AGED; ANGINA PECTORIS; ANGIOCARDIOGRAPHY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DISEASE; ENDOTHELIAL DYSFUNCTION; EPICARDIUM; EXERCISE TEST; FEMALE; HUMAN; HYPOTHESIS; MALE; PRIORITY JOURNAL; SCORING SYSTEM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; VASODILATATION;

CORONARY ARTERY DISEASE; DIPYRIDAMOLE; EXERCISE TEST; FEMALE; HUMANS; MALE; MICROCIRCULATION; MIDDLE AGED; PERICARDIUM; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; VASODILATOR AGENTS; VASOMOTOR SYSTEM; VENTRICULAR DYSFUNCTION, LEFT;

EID: 36049030315     PISSN: 10713581     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nuclcard.2007.05.013     Document Type: Article

References (33)

1. Lee J., Chea S.C., Lee K., Heo J., and Iskandrian A.S. Biokinetics of thallium-201 in normal subjects: comparison between adenosine, dipyridamole, dobutamine and exercise. J Nucl Med 35 (1994) 535-541
2. Levine M.G., Ahlberg M.A., Mann A., White M.P., McGill C.C., Mendes de Leon C., et al. Comparison of exercise, dipyridamole, adenosine and dobutamine stress with the use of Tc-99m tetrofosmin tomographic imaging. J Nucl Cardiol 6 (1999) 389-396
3. Chow B.J., Beandlands R.S., Lee A., DaSilva J.N., deKemp R.A., Alkahtani A., et al. Treadmill exercise produces larger perfusion defects than dipyridamole stress N-13 ammonia positron emission tomography. J Am Coll Cardiol 47 (2006) 411-416
4. Inobe Y., Kugiyama K., Morita E., Kawano H., Okumura K., Tomiguchi S., et al. Role of adenosine in pathogenesis of syndrome X: assessment with coronary hemodynamic measurements and thallium-201 myocardial single photon emission computed tomography. J Am Coll Cardiol 28 (1996) 890-896
5. David N., Marie P.Y., Angioi M., Rodriguez R.M., Hassan N., Olivier P., et al. Dipyridamole and exercise SPET provide different estimates of myocardial ischemic area: role of severity of coronary stenoses and of the increase in heart rate. Eur J Nucl Med 27 (2000) 788-799
6. Loscalzo J., and Vita J.A. Ischemia, hyperemia, exercise and nitric oxide. Complex physiology and complex molecular adaptations. Circulation 90 (1994) 2556-2559
7. Drexler H., Zeiher A.M., Wollschlager H., Meinertz T., Just H., and Bonzel T. Flow-dependent coronary artery dilatation in humans. Circulation 80 (1989) 466-474
8. Zeiher A.M., Krause T., Schachinger V., Minners J., and Moser E. Impaired endothelium-dependent vasodilatation of coronary resistance vessels is associated with exercise induced myocardial ischemia. Circulation 91 (1995) 2345-2352
9. Knabb R.M., Gidday J.M., Ely S.W., Rubio R., and Berne R.M. Effect of dipyridamole on myocardial adenosine and active hyperemia. Am J Physiol 247 (1984) H804-H810
10. Fitgerald G.A. Dipyridamole. N Engl J Med 316 (1987) 1247-1256
11. Olsson R.A., and Pearson J.D. Cardiovascular purinoceptors. Physiol Rev 70 (1990) 761-845
12. Chan S.Y., Brunken R.C., Czernin J., Porenta G., Kuhle W., Krivokapich J., et al. Comparison of maximal myocardial blood flow during adenosine infusion with that of intravenous dipyridamole in normal men. J Am Coll Cardiol 20 (1992) 979-985
13. Santos-Ocampo C.D., Herman S.D., Travin M.I., Garber C.E., Ahlberg A.W., Messinger D.E., et al. Comparison of exercise, dipyridamole and adenosine by use of technetium 99m sestamibi tomographic imaging. J Nucl Cardiol 1 (1994) 57-64
14. Cow B.J., Ananthasubramaniam K., Dekemp R.A., Dalipaj M.M., Beanlands R.S., and Rubby T.D. Comparison of treadmill exercise versus dipyridamole stress with myocardial perfusion imaging using rubidium-82 positron emission tomography. J Am Coll Cardiol 45 (2005) 1227-1234
15. Cuocolo A., Nicolai E., Soricelli A., Pace L., Nappi A., Sullo P., et al. Technetium 99m-labeled tetrofosmin myocardial tomography in patients with coronary artery disease: comparison between adenosine and dynamic exercise stress testing. J Nucl Cardiol 3 (1996) 194-203
16. Doucette J.W., Corl D.P., Payne H.M., Flynn A.E., Goto M., Nassi M., et al. Validation of a Doppler guide wire for intravascular measurements of coronary artery flow velocity. Circulation 85 (1992) 1899-1911
17. Hasdai D., Gibbson R.J., Holmes D.R., Higano S.T., and Lerman A. Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects. Circulation 96 (1997) 3390-3395
18. Gibbons R.J., Balady G.J., Bricker J.T., Chaitman B.R., Fletcher G.F., Froelicher V.F., et al. ACC/AHA 2002 guideline update for exercise testing: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). J Am Coll Cardiol 40 (2002) 1531-1540
19. Cerqueira M.D., Weissman N.J., Dilsizian V., Jacobs A.K., Kaul S., Laskey W.K., et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council of Clinical Cardiology of the American Heart Association. J Nucl Cardiol 9 (2002) 240-245
20. Meller J., Goldsmith S.J., Rudin A., Pichard A.D., Gorlin R., Teichholz L.E., et al. Spectrum of exercise thallium-201 myocardial perfusion imaging in patients with chest pain and normal coronary angiograms. Am J Cardiol 43 (1979) 717-723
21. Legrand V., Hodgson J.M., Bates E.R., Aueron F.M., Mancini G.B., Hodgson J.M., et al. Abnormal coronary flow reserve and abnormal radionuclide exercise test results in patients with normal coronary arteriograms. J Am Coll Cardiol 6 (1985) 1245-1253
22. Cannon R.O., and Epstein S.E. "Microvascular angina" as a cause of chest pain with angiographically normal coronary arteries. Am J Cardiol 61 (1988) 1338-1343
23. Bottcher M., Botker H.E., Sonne H., Nielsen T.T., and Czernin J. Endothelium-dependent and -independent perfusion reserve and the effect of L-arginine on myocardial perfusion in patients with syndrome X. Circulation 99 (1999) 1795-1801
24. Egashira K., Inoue T., Hirooka Y., Yamada A., Urabe Y., and Takeshita A. Evidence of impaired endothelium-dependent coronary vasodilatation in patients with angina pectoris and normal coronary arteriograms. N Engl J Med 328 (1993) 1659-1664
25. Gould K.L. Assessing progression or regression of CAD: the role of perfusion imaging. J Nucl Cardiol 12 (2005) 625-638
26. Johnson N.P., and Gould L.K. Clinical evaluation of a new concept: resting myocardial perfusion heterogeneity quantified by Markovian analysis of PET identifies coronary microvascular dysfunction and early atherosclerosis in 1034 subjects. J Nucl Med 46 (2005) 1427-1437
27. Zeiher A.M., Drexler H., Wollschlager H., and Just H. Modulation of coronary vasomotion tone in humans: progressive endothelial dysfunction with different early stage of coronary atherosclerosis. Circulation 83 (1991) 391-401
28. Sudhir K., MacGregor J.S., Amidon T.M., Gupta M., Yock P.G., and Ghatterjee K. Differential contribution of nitric oxide to regulation of vascular tone in coronary conductance and resistance arteries: intravascular ultrasound studies. Am Heart J 127 (1994) 858-865
29. Zeiher A.M., Krause T., Schachinger V., Minners J., and Moser E. Impaired endothelium-dependent vasodilatation of coronary resistance vessels is associated with exercise induced myocardial ischemia. Circulation 91 (1995) 2345-2352
30. Gordon J.B., Ganz P., Nabel K.G., Fish R.H., Zebede J., Mudge G.H., et al. Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise. J Clin Invest 83 (1989) 1946-1952
31. Buus N.H., Bottcher M., Hermansen F., Sander M., Nielsen T.T., and Mulvany M.J. Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia. Circulation 104 (2001) 2305-2310
32. Heller G.V. Tracer selection with different stress modalities based on tracer kinetics. J Nucl Cardiol 3 (1996) S15-S21
33. Halcox J., Schenke W., Zalos G., Mincemoyer R., Waclawiw M., Rivera C.E., et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation 106 (2002) 653-658