HER-3 in colorectal tumourigenesis: From mRNA levels through protein status to clinicopathologic relationships

European Journal of Cancer

Volumn 43, Issue 17, 2007, Pages 2602-2611

  Grivas, Petros D ^a   Antonacopoulou, Anna ^a   Tzelepi, Vassiliki ^b   Sotiropoulou Bonikou, Georgia ^b   Kefalopoulou, Zinovia ^b   Papavassiliou, Athanasios G ^c   Kalofonos, Haralabos ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Colorectal cancer; HER 3; Immunohistochemistry; pHER 3; Tumourigenesis

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 3; MESSENGER RNA;

ADENOMA; ADULT; AGED; ARTICLE; CANCER STAGING; CARCINOGENESIS; CELL MEMBRANE; CELL NUCLEUS; COLORECTAL CANCER; CONTROLLED STUDY; CYTOPLASM; DISEASE COURSE; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOPOGRAPHY;

ADULT; AGED; AGED, 80 AND OVER; CELL NUCLEUS; COLORECTAL NEOPLASMS; CYTOPLASM; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; RECEPTOR, ERBB-3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 36148950632     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2007.08.019     Document Type: Article

References (30)

1. Karamouzis M.V., Badra F.A., and Papavassiliou A.G. Breast cancer: the upgraded role of HER-3 and HER-4. Int J Biochem Cell Biol 39 (2007) 851-856
2. Harris R.C., Chung E., and Coffey R.J. EGF receptor ligands. Exp Cell Res 284 (2003) 2-13
3. Citri A., Skaria K.B., and Yarden Y. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res 284 (2003) 54-65
4. Tzahar E., and Yarden Y. The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands. Biochim Biophys Acta 1377 (1998) M25-M37
5. Mendelsohn J. The epidermal growth factor receptor as a target for cancer therapy. Endocr Relat Cancer 8 (2001) 3-9
6. Mendelsohn J., and Baselga J. Epidermal growth factor receptor targeting in cancer. Semin Oncol 33 (2006) 369-385
7. Guy P.M., Platko J.V., Cantley L.C., Cerione R.A., and Carraway III K.L. Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc Natl Acad Sci U S A 91 (1994) 8132-8136
8. Prigent S.A., Lemoine N.R., Hughes C.M., Plowman G.D., Selden C., and Gullick W.J. Expression of the c-erbB-3 protein in normal human adult and fetal tissues. Oncogene 7 (1992) 1273-1278
9. Poller D.N., Spendlove I., Baker C., et al. Production and characterization of a polyclonal antibody to the c-erbB-3 protein: examination of c-erbB-3 protein expression in adenocarcinomas. J Pathol 168 (1992) 275-280
10. Tanner B., Hasenclever D., Stern K., et al. ErbB-3 predicts survival in ovarian cancer. J Clin Oncol 24 (2006) 4317-4323
11. Badra F.A., Karamouzis M.V., Ravazoula, et al. Non-palpable breast carcinomas: correlation of mammographically detected malignant-appearing microcalcifications and epidermal growth factor receptor (EGFR) family expression. Cancer Lett 244 (2006) 34-41
12. Lee J.C., Wang S.T., Chow N.H., and Yang H.B. Investigation of the prognostic value of coexpressed erbB family members for the survival of colorectal cancer patients after curative surgery. Eur J Cancer 38 (2002) 1065-1071
13. Maurer C.A., Friess H., Kretschmann B., et al. Increased expression of erbB3 in colorectal cancer is associated with concomitant increase in the level of erbB2. Hum Pathol 29 (1998) 771-777
14. Kapitanovic S., Radosevic S., Slade N., et al. Expression of erbB-3 protein in colorectal adenocarcinoma: correlation with poor survival. J Cancer Res Clin Oncol 126 (2000) 205-211
15. Sergina N.V., Rausch M., Wang D., et al. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 445 (2007) 437-441
16. Hellyer N.J., Cheng K., and Koland J.G. ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase. Biochem J 333 Pt 3 (1998) 757-763
17. Engelman J.A., and Cantley L.C. The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors. Clin Cancer Res 12 (2006) 4372s-4376s
18. Fujimoto N., Wislez M., Zhang J., et al. High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Res 65 (2005) 11478-11485
19. Buck E., Eyzaguirre A., Haley J.D., Gibson N.W., Cagnoni P., and Iwata K.K. Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity. Mol Cancer Ther 5 (2006) 2051-2059
20. Taron M., Rosell R., Felip E., et al. BRCA1 mRNA expression levels as an indicator of chemoresistance in lung cancer. Hum Mol Genet 13 (2004) 2443-2449
21. Rajkumar T., Gooden C.S., Lemoine N.R., Gullick W.J., and Goden C.S. Expression of the c-erbB-3 protein in gastrointestinal tract tumours determined by monoclonal antibody RTJ1. J Pathol 170 (1993) 271-278
22. Kountourakis P., Pavlakis K., Psyrri A., et al. Prognostic significance of HER3 and HER4 protein expression in colorectal adenocarcinomas. BMC Cancer 6 (2006) 46
23. Koumakpayi I.H., Diallo J.S., Le Page C., et al. Expression and nuclear localization of ErbB3 in prostate cancer. Clin Cancer Res 12 (2006) 2730-2737
24. Lo H.W., Xia W., Wei Y., Ali-Seyed M., Huang S.F., and Hung M.C. Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Res 65 (2005) 338-348
25. Lin S.Y., Makino K., Xia W., et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 3 (2001) 802-808
26. Offterdinger M., Schofer C., Weipoltshammer K., and Grunt T.W. c-erbB-3: a nuclear protein in mammary epithelial cells. J Cell Biol 157 (2002) 929-939
27. Srinivasan R., Gillett C.E., Barnes D.M., and Gullick W.J. Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers. Cancer Res 60 (2000) 1483-1487
28. Ciardiello F., Kim N., Saeki T., et al. Differential expression of epidermal growth factor-related proteins in human colorectal tumors. Proc Natl Acad Sci U S A 88 (1991) 7792-7796
29. Jassam N., Bell S.M., Speirs V., and Quirke P. Loss of expression of oestrogen receptor beta in colon cancer and its association with Dukes' staging. Oncol Rep 14 (2005) 17-21
30. Kalofonos H.P., and Grivas P.D. Monoclonal antibodies in the management of solid tumors. Curr Top Med Chem 6 (2006) 1687-1705