Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schönlein purpura

Pediatric Nephrology

Volumn 22, Issue 12, 2007, Pages 2067-2072

  Lau, Keith K ^a   Wyatt, Robert J ^b   Moldoveanu, Zina ^c   Tomana, Milan ^d   Julian, Bruce A ^c   Hogg, Ronald J ^e   Lee, Jeannette Y ^d   Huang, Wen Qiang ^c   Mestecky, Jiri ^c   Novak, Jan ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c University of Alabama at Birmingham   (United States)

^d University of Alabama at Birmingham   (United States)

^e ST JOSEPH'S HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

Aberrant glycosylation; Henoch Sch nlein purpura; IgA nephropathy; IgA1; Lectin ELISA

Indexed keywords

COMPLEMENT COMPONENT C1Q; GALACTOSE; GLYCAN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A1; LECTIN;

ADOLESCENT; ANAPHYLACTOID PURPURA; ARTICLE; CHILD; CHILD HEALTH; CONTROLLED STUDY; DIAGNOSTIC TEST; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNE COMPLEX NEPHRITIS; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOGLOBULIN BLOOD LEVEL; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION;

ADOLESCENT; CHILD; COHORT STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GALACTOSE; GLOMERULONEPHRITIS, IGA; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN A; LECTINS; MALE; PURPURA, SCHOENLEIN-HENOCH;

EID: 36049048268     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-007-0623-y     Document Type: Article

References (29)

1. D'Amico G (1987) The commonest glomerulonephritis in the world: IgA nephropathy. Q J Med 64:709-727
2. Delos Santos NM, Wyatt RJ (2004) Pediatric IgA nephropathies: Clinical aspects and therapeutic approaches. Semin Nephrol 24:269-286
3. Saulsbury FT (2001) Henoch-Schönlein purpura. Curr Opin Rheumatol 13:35-40
4. Levy M, Broyer M, Arsan A, Levy-Bentolila D, Habib R (1976) Anaphylactoid purpura nephritis in childhood: Natural history and immunopathology. Adv Nephrol 6:183-228
5. Evans DJ, Gwynn-Williams D, Peters DK, Sissons JG, Boulton-Jones JM, Ogg CS, Cameron JS, Hoffbrand BI (1973) Glomerular deposition of properdin in Henoch-Schönlein purpura syndrome and idiopathic focal glomerulonephritis. Br Med J 11:326-328
6. Meadow SR, Scott DG (1985) Berger disease: Henoch-Schönlein syndrome without the rash. J Pediatr 106:27-32
7. Levy M (1989) Familial cases of Berger's disease and anaphylactoid purpura: More frequent than previously thought. Am J Med 87:246-248
8. Nakamoto Y, Asano Y, Dohi K, Fujioka M, Iida H, Kida H, Kibe Y, Hattori N, Takeuchi J (1978) Primary IgA glomerulonephritis and Schonlein-Henoch purpura nephritis: Clinicopathological and immunohistological characteristics. Q J Med 47:495-516
9. Waldo FB (1988) Is Henoch-Schönlein purpura the systemic form of IgA nephropathy? Am J Kidney Dis 12:373-377
10. Andre PM, Le Pogamp P, Chevet D (1990) Impairment of jacalin binding to serum IgA in IgA nephropathy. J Clin Lab Anal 4:115-119
11. Mestecky J, Tomana M, Crowley-Nowick PA, Moldoveanu Z, Julian BA, Jackson S (1993) Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy. Contrib Nephrol 104:172-182
12. Allen AC, Harper SJ, Feehally J (1995) Galactosylation of N- and O -linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy. Clin Exp Immunol 100:470-474
13. Tomana M, Matousovic K, Julian BA, Radl J, Konecny K, Mestecky J (1997) Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG. Kidney Int 52:509-516
14. Allen AC, Willis FR, Beattie TJ, Feehally J (1998) Abnormal IgA glycosylation in Henoch-Schönlein purpura restricted to patients with clinical nephritis. Nephrol Dial Transplant 13:930-934
15. Coppo R, Basolo B, Martina G, Rollino C, De Marchi M, Giacchino F, Mazzucco G, Messina M, Piccoli G (1982) Circulating immune complexes containing IgA, IgG and IgM in patients with primary IgA nephropathy and with Henoch-Schönlein nephritis. Correlation with clinical and histologic signs of activity. Clin Nephrol 18:230-239
16. Amore A, Cirina P, Conti G, Brusa P, Peruzzi L, Coppo R (2001) Glycosylation of circulating IgA in patients with IgA nephropathy modulates proliferation and apoptosis of mesangial cells. J Am Soc Nephrol 12:1862-1871
17. Coppo R, Amore A (2004) Aberrant glycosylation in IgA nephropathy (IgAN). Kidney Int 65:1544-1547
18. Novak J, Tomana M, Matousovic K, Brown R, Hall S, Novak L, Julian BA, Wyatt RJ, Mestecky J (2005) IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells. Kidney Int 67:504-513
19. Hogg R, Tomana M, Gray J, Mestecky J (1997) Deficient IgA1 galactosylation in children with idiopatic IgA nephropathy (IgAN) and Henoch-Schönlein nephritis (HSPN). J Am Soc Nephrol 8:88A
20. Moore JS, Kulhavy R, Tomana M, Moldoveanu Z, Suzuki H, Brown R, Hall S, Kilian M, Poulsen K, Mestecky J, Julian BA, Novak J (2007) Reactivities of N -acetylgalactosamine-specific lectins with human IgA1 proteins. Mol Immunol 44:2598-2604
21. Moldoveanu Z, Wyatt RJ, Lee J, Tomana M, Julian BA, Mestecky J, Huang W-Q, Anreddy SR, Hastings MC, Lau KK, Cook WJ, Novak J (2007) Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Kidney Int 71:134-138
22. Schwartz GJ, Haycock GB, Edelman CM Jr, Spitzer A (1976) A simple estimate of glomerular filtration rate in children derived from body length and serum creatinine. Pediatrics 58:522-526
23. Tomana M, Novak J, Julian BA, Matousovic K, Konecny K, Mestecky J (1999) Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. J Clin Invest 104:73-81
24. Yoshikawa N, Ito H, Nakamura H (1992) Prognostic indicators in childhood IgA nephropathy. Nephron 60:60-67
25. Ariceta G, Gallego N, Lopez-Fernandez Y, Vallo A, Quintella MJ, Rodriquez Soriano J (2001) Long-term prognosis of childhood IgA nephropathy in adult life. Med Clin 116:361-364
26. Delos Santos NM, Ault BH, Gharavi AG, Kritchevsky SB, Quasney MW, Jackson EC, Fisher KA, Woodford SY, Mitchell BL, Gaber LW, Arheart KL, Wyatt RJ (2002) Angiotensin-converting enzyme genotype and outcome in pediatric IgA nephropathy. Pediatr Nephrol 17:496-502
27. Yoshikawa N, Iijima K, Matsuyama S, Suzuki J, Kameda A, Okada S, Nakamura H (1990) Repeat renal biopsy in children with IgA nephropathy. Clin Nephrol 33:160-167
28. Xu LX, Zhao MH (2005) Aberrantly glycosylated serum IgA1 are closely associated with pathologic phenotypes of IgA nephropathy. Kidney Int 68:167-172
29. Lau KK, Wyatt RJ, Gaber LW (2005) Purpura followed by proteinuria in a 7-year-old girl. Am J Kidney Dis 46:1140-1144