메뉴 건너뛰기




Volumn 43, Issue 17, 2007, Pages 2612-2620

A novel angiogenesis inhibitor, Ki23057, is useful for preventing the progression of colon cancer and the spreading of cancer cells to the liver

Author keywords

Angionenesis inhibitor; Colon cancer therapy; Molecular target therapy; VEGFR2 autophosphorylation inhibitor

Indexed keywords

ANGIOGENESIS INHIBITOR; KI 23057; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

EID: 36049046092     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2007.09.002     Document Type: Article
Times cited : (11)

References (28)
  • 1
    • 12344263868 scopus 로고    scopus 로고
    • KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth
    • Nakamura K., Yamamoto A., Kamishohara M., et al. KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth. Mol Cancer Ther 3 (2004) 1639-1649
    • (2004) Mol Cancer Ther , vol.3 , pp. 1639-1649
    • Nakamura, K.1    Yamamoto, A.2    Kamishohara, M.3
  • 2
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge S.R., Ogilvie D.J., Dukes M., et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 62 (2002) 4645-4655
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 3
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel D.B., Laird A.D., Xin X., et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 9 (2003) 327-337
    • (2003) Clin Cancer Res , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 4
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker B.J., Tamura S., Buchdunger E., et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 2 (1996) 561-566
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 5
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Demetri G.D., von Mehren M., Blanke C.D., et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 347 (2002) 472-480
    • (2002) N Engl J Med , vol.347 , pp. 472-480
    • Demetri, G.D.1    von Mehren, M.2    Blanke, C.D.3
  • 6
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350 (2004) 2335-2342
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 7
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G., and Benjamin L.E. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3 (2003) 401-410
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 9
    • 84970070220 scopus 로고
    • Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
    • Takahashi Y., Kitadai Y., Bucana C.D., Cleary K.R., and Ellis L.M. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 55 (1995) 3964-3968
    • (1995) Cancer Res , vol.55 , pp. 3964-3968
    • Takahashi, Y.1    Kitadai, Y.2    Bucana, C.D.3    Cleary, K.R.4    Ellis, L.M.5
  • 10
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat Med 9 (2003) 669-676
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 11
    • 0034650802 scopus 로고    scopus 로고
    • Regulation of angiogenesis via vascular endothelial growth factor receptors
    • Veikkola T., Karkkainen M., Claesson-Welsh L., and Alitalo K. Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Res 60 (2000) 203-212
    • (2000) Cancer Res , vol.60 , pp. 203-212
    • Veikkola, T.1    Karkkainen, M.2    Claesson-Welsh, L.3    Alitalo, K.4
  • 12
    • 0035355472 scopus 로고    scopus 로고
    • A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
    • Takahashi T., Yamaguchi S., Chida K., and Shibuya M. A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. Embo J 20 (2001) 2768-2778
    • (2001) Embo J , vol.20 , pp. 2768-2778
    • Takahashi, T.1    Yamaguchi, S.2    Chida, K.3    Shibuya, M.4
  • 13
    • 22244452376 scopus 로고    scopus 로고
    • VEGF-targeted therapy: therapeutic potential and recent advances
    • Rosen L.S. VEGF-targeted therapy: therapeutic potential and recent advances. Oncologist 10 (2005) 382-391
    • (2005) Oncologist , vol.10 , pp. 382-391
    • Rosen, L.S.1
  • 14
    • 0030707635 scopus 로고    scopus 로고
    • Combined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasis
    • Kang S.M., Maeda K., Onoda N., et al. Combined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasis. Int J Cancer 74 (1997) 502-507
    • (1997) Int J Cancer , vol.74 , pp. 502-507
    • Kang, S.M.1    Maeda, K.2    Onoda, N.3
  • 15
    • 0033638716 scopus 로고    scopus 로고
    • Soluble vascular endothelial growth factor levels in patients with primary colorectal carcinoma. The Danish RANX05 Colorectal Cancer Study Group
    • Werther K., Christensen I.J., Brunner N., and Nielsen H.J. Soluble vascular endothelial growth factor levels in patients with primary colorectal carcinoma. The Danish RANX05 Colorectal Cancer Study Group. Eur J Surg Oncol 26 (2000) 657-662
    • (2000) Eur J Surg Oncol , vol.26 , pp. 657-662
    • Werther, K.1    Christensen, I.J.2    Brunner, N.3    Nielsen, H.J.4
  • 16
    • 10744233960 scopus 로고    scopus 로고
    • Orally active anti-proliferation agents: novel diphenylamine derivatives as FGF-R2 autophosphorylation inhibitors
    • Shimizu T., Fujiwara Y., Osawa T., et al. Orally active anti-proliferation agents: novel diphenylamine derivatives as FGF-R2 autophosphorylation inhibitors. Bioorg Med Chem Lett 14 (2004) 875-879
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 875-879
    • Shimizu, T.1    Fujiwara, Y.2    Osawa, T.3
  • 17
    • 0030837804 scopus 로고    scopus 로고
    • Increased sialyl Lewis A expression and fucosyltransferase activity with acquisition of a high metastatic capacity in a colon cancer cell line
    • Yamada N., Chung Y.S., Takatsuka S., et al. Increased sialyl Lewis A expression and fucosyltransferase activity with acquisition of a high metastatic capacity in a colon cancer cell line. Br J Cancer 76 (1997) 582-587
    • (1997) Br J Cancer , vol.76 , pp. 582-587
    • Yamada, N.1    Chung, Y.S.2    Takatsuka, S.3
  • 18
    • 33750701827 scopus 로고    scopus 로고
    • A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer
    • Nakamura K., Yashiro M., Matsuoka T., et al. A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer. Gastroenterology 131 (2006) 1530-1541
    • (2006) Gastroenterology , vol.131 , pp. 1530-1541
    • Nakamura, K.1    Yashiro, M.2    Matsuoka, T.3
  • 19
    • 0034243139 scopus 로고    scopus 로고
    • Contribution of angiogenesis to the progression of colon cancer: possible inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and hepatic metastasis
    • Takatsuka S., Yamada N., Sawada T., et al. Contribution of angiogenesis to the progression of colon cancer: possible inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and hepatic metastasis. Int J Oncol 17 (2000) 253-258
    • (2000) Int J Oncol , vol.17 , pp. 253-258
    • Takatsuka, S.1    Yamada, N.2    Sawada, T.3
  • 20
    • 0037075812 scopus 로고    scopus 로고
    • Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors
    • Hennequin L.F., Stokes E.S., Thomas A.P., et al. Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors. J Med Chem 45 (2002) 1300-1312
    • (2002) J Med Chem , vol.45 , pp. 1300-1312
    • Hennequin, L.F.1    Stokes, E.S.2    Thomas, A.P.3
  • 21
    • 20044382799 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
    • Strumberg D., Richly H., Hilger R.A., et al. Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J Clin Oncol 23 (2005) 965-972
    • (2005) J Clin Oncol , vol.23 , pp. 965-972
    • Strumberg, D.1    Richly, H.2    Hilger, R.A.3
  • 22
    • 3142774878 scopus 로고    scopus 로고
    • AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity
    • Traxler P., Allegrini P.R., Brandt R., et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 64 (2004) 4931-4941
    • (2004) Cancer Res , vol.64 , pp. 4931-4941
    • Traxler, P.1    Allegrini, P.R.2    Brandt, R.3
  • 23
    • 20944441692 scopus 로고    scopus 로고
    • Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials
    • Drevs J., Zirrgiebel U., Schmidt-Gersbach C.I., et al. Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials. Ann Oncol 16 (2005) 558-565
    • (2005) Ann Oncol , vol.16 , pp. 558-565
    • Drevs, J.1    Zirrgiebel, U.2    Schmidt-Gersbach, C.I.3
  • 24
    • 20544471876 scopus 로고    scopus 로고
    • Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
    • Kabbinavar F.F., Hambleton J., Mass R.D., Hurwitz H.I., Bergsland E., and Sarkar S. Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol 23 (2005) 3706-3712
    • (2005) J Clin Oncol , vol.23 , pp. 3706-3712
    • Kabbinavar, F.F.1    Hambleton, J.2    Mass, R.D.3    Hurwitz, H.I.4    Bergsland, E.5    Sarkar, S.6
  • 25
    • 34347236908 scopus 로고    scopus 로고
    • Front-line bevacizumab in combination with oxaliplatin, leucovorin and 5-fluorouracil (FOLFOX) in patients with metastatic colorectal cancer: a multicenter phase II study
    • Emmanouilides C., Sfakiotaki G., Androulakis N., et al. Front-line bevacizumab in combination with oxaliplatin, leucovorin and 5-fluorouracil (FOLFOX) in patients with metastatic colorectal cancer: a multicenter phase II study. BMC Cancer 7 (2007) 91
    • (2007) BMC Cancer , vol.7 , pp. 91
    • Emmanouilides, C.1    Sfakiotaki, G.2    Androulakis, N.3
  • 26
    • 0036057596 scopus 로고    scopus 로고
    • Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): a review
    • Malet-Martino M., and Martino R. Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): a review. Oncologist 7 (2002) 288-323
    • (2002) Oncologist , vol.7 , pp. 288-323
    • Malet-Martino, M.1    Martino, R.2
  • 27
    • 0034856316 scopus 로고    scopus 로고
    • Capecitabine: a novel agent for the treatment of solid tumors
    • Johnston P.G., and Kaye S. Capecitabine: a novel agent for the treatment of solid tumors. Anticancer Drugs 12 (2001) 639-646
    • (2001) Anticancer Drugs , vol.12 , pp. 639-646
    • Johnston, P.G.1    Kaye, S.2
  • 28
    • 0346059590 scopus 로고    scopus 로고
    • Keratinocyte growth factor produced by gastric fibroblasts specifically stimulates proliferation of cancer cells from scirrhous gastric carcinoma
    • Nakazawa K., Yashiro M., and Hirakawa K. Keratinocyte growth factor produced by gastric fibroblasts specifically stimulates proliferation of cancer cells from scirrhous gastric carcinoma. Cancer Res 63 (2003) 8848-8852
    • (2003) Cancer Res , vol.63 , pp. 8848-8852
    • Nakazawa, K.1    Yashiro, M.2    Hirakawa, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.