Overexpression of HAM1 gene detoxifies 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae

Current Genetics

Volumn 52, Issue 5-6, 2007, Pages 203-211

  Takayama, Shinichi ^a   Fujii, Michihiko ^a   Kurosawa, Aya ^a   Adachi, Noritaka ^a   Ayusawa, Dai ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

BrdU; Ham1; Noncanonical nucleotides; Saccharomyces cerevisiae

Indexed keywords

BROXURIDINE; FUNGAL DNA; FUNGAL PROTEIN; GENOMIC DNA; PROTEIN HAM1; PYROPHOSPHATE; UNCLASSIFIED DRUG; URIDINE PHOSPHATE; URIDINE TRIPHOSPHATE;

ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; FUNGAL GENETICS; FUNGAL STRAIN; FUNGUS GROWTH; GENE OVEREXPRESSION; GROWTH INHIBITION; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; SACCHAROMYCES CEREVISIAE; SUPPRESSOR GENE; YEAST CELL;

BROMODEOXYURIDINE; DRUG RESISTANCE, FUNGAL; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; GENETIC VECTORS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 36049046022     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00294-007-0152-z     Document Type: Article

References (24)

1. Ames BN (1989) Endogenous DNA damage as related to cancer and aging. Mutat Res 214:41-46
2. Bick MD, Devine EA (1977) Interaction of chromosomal proteins with BrdU substituted DNA as determined by chromatin-DNA competition. Nucleic Acids Res 4:3687-3700
3. Burgis NE, Cunningham RP (2007) Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase. J Biol Chem 282:3531-3538
4. Fasy TM, Cullen BR, Luk D, Bick MD (1980) Studies on the enhanced interaction of halodeoxyuridine-substituted DNAs with H1 histones and other polypeptides. J Biol Chem 255:1380-1387
5. Fujii M, Ito H, Hasegawa T, Suzuki T, Adachi N, Ayusawa D (2002) 5-Bromo-2′-deoxyuridine efficiently suppresses division potential of the yeast Saccharomyces cerevisiae. Biosci Biotechnol Biochem 66:906-909
6. Fujii M, Ogata T, Takahashi E, Yamada K, Nakabayashi K, Oishi M, Ayusawa D (1995) Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells. FEBS Lett 375:263-267
7. Hwang KY, Chung JH, Kim SH, Han YS, Cho Y (1999) Structure-based identification of a novel NTPase from Methanococcus jannaschii. Nat Struct Biol 6:691-696
8. Kohalmi SE, Glattke M, McIntosh EM, Kunz BA (1991) Mutational specificity of DNA precursor pool imbalances in yeast arising from deoxycytidylate deaminase deficiency or treatment with thymidylate. J Mol Biol 220:933-946
9. Lin S, Lin D, Riggs AD (1976) Histones bind more tightly to bromodeoxyuridine-substituted DNA than to normal DNA. Nucleic Acids Res 3:2183-2191
10. Lin S, McLennan AG, Ying K, Wang Z, Gu S, Jin H, Wu C, Liu W, Yuan Y, Tang R, Xie Y, Mao Y (2001) Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene. J Biol Chem 276:18695-18701
11. Lin SY, Riggs AD (1976) The binding of lac repressor and the catabolite gene activator protein to halogen-substituted analogues of poly[d(A-T)]. Biochim Biophys Acta 432:185-191
12. Michishita E, Kurahashi T, Suzuki T, Fukuda M, Fujii M, Hirano H, Ayusawa D (2002) Changes in nuclear matrix proteins during the senescence-like phenomenon induced by 5-chlorodeoxyuridine in HeLa cells. Exp Gerontol 37:885-890
13. Minagawa S, Nakabayashi K, Fujii M, Scherer SW, Ayusawa D (2004) Functional and chromosomal clustering of genes responsive to 5-bromodeoxyuridine in human cells. Exp Gerontol 39:1069-1078
14. Minagawa S, Nakabayashi K, Fujii M, Scherer SW, Ayusawa D (2005) Early BrdU-responsive genes constitute a novel class of senescence-associated genes in human cells. Exp Cell Res 304:552-558
15. Noskov VN, Staak K, Shcherbakova PV, Kozmin SG, Negishi K, Ono BC, Hayatsu H, Pavlov YI (1996) HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis in the yeast Saccharomyces cerevisiae. Yeast 12:17-29
16. Pavlov YI, Noskov VN, Lange EK, Moiseeva EV, Pshenichnov MR, Khromov-Borisov NN (1991) The genetic activity of N6-hydroxyadenine and 2-amino-N6-hydroxyadenine in Escherichia coli, Salmonella typhimurium and Saccharomyces cerevisiae. Mutat Res 253:33-46
17. Satou W, Suzuki T, Noguchi T, Ogino H, Fujii M, Ayusawa D (2004) AT-hook proteins stimulate induction of senescence markers triggered by 5-bromodeoxyuridine in mammalian cells. Exp Gerontol 39:173-179
18. Shcherbakova PV, Noskov VN, Pshenichnov MR, Pavlov YI (1996) Base analog 6-N-hydroxylaminopurine mutagenesis in the yeast Saccharomyces cerevisiae is controlled by replicative DNA polymerases. Mutat Res 369:33-44
19. Stenmark P, Kursula P, Flodin S, Graslund S, Landry R, Nordlund P, Schuler H (2007) Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T. J Biol Chem 282:3182-3187
20. Suzuki T, Michishita E, Ogino H, Fujii M, Ayusawa D (2002) Synergistic induction of the senescence-associated genes by 5-bromodeoxyuridine and AT-binding ligands in HeLa cells. Exp Cell Res 276:174-184
21. Suzuki T, Minagawa S, Michishita E, Ogino H, Fujii M, Mitsui Y, Ayusawa D (2001a) Induction of senescence-associated genes by 5-bromodeoxyuridine in HeLa cells. Exp Gerontol 36:465-474
22. Suzuki T, Yaginuma M, Oishi T, Michishita E, Ogino H, Fujii M, Ayusawa D (2001b) 5-Bromodeoxyuridine suppresses position effect variegation of transgenes in HeLa cells. Exp Cell Res 266:53-63
23. Wilt FH, Anderson M (1972) The action of 5-bromodeoxyuridine on differentiation. Dev Biol 28:443-447
24. Zakharov AF, Baranovskaya LI, Ibraimov AI, Benjusch VA, Demintseva VS, Oblapenko NG (1974) Differential spiralization along mammalian mitotic chromosomes. II. 5-bromodeoxyuridine and 5-bromodeoxycytidine-revealed differentiation in human chromosomes. Chromosoma 44:343-359