Temporal change in human nicotinic acetylcholine receptor after smoking cessation: 5IA SPECT study

Journal of Nuclear Medicine

Volumn 48, Issue 11, 2007, Pages 1829-1835

  Mamede, Marcelo ^a   Ishizu, Koichi ^a   Ueda, Masashi ^a   Mukai, Takahiro ^a   Iida, Yasuhiko ^a   Kawashima, Hidekazu ^a   Fukuyama, Hidenao ^a   Togashi, Kaori ^a   Saji, Hideo ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

123I 5IA; Human brain; Nicotinic acetylcholine receptors; Quantitative measurement; Smoking withdrawal; SPECT

Indexed keywords

3 (2 AZETIDINYLMETHOXY)PYRIDINE; 3 (2 AZETIDINYLMETHOXY)PYRIDINE I 123; CONTRAST MEDIUM; IODINE 123; NICOTINE; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BINDING AFFINITY; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; HUMAN; ISOTOPE LABELING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR UPREGULATION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMOKING; SMOKING CESSATION;

ADULT; AZETIDINES; BRAIN; HUMANS; IODINE RADIOISOTOPES; MALE; NICOTINIC AGONISTS; RADIOPHARMACEUTICALS; RECEPTORS, NICOTINIC; SMOKING CESSATION; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; UP-REGULATION;

EID: 36049038636     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.107.043471     Document Type: Article

References (35)

1. Gotti C, Fornasari D, Clementi F. Human neuronal nicotinic receptors. Prog Neurobiol. 1997;53:199-237.
2. Paterson D, Nordberg A. Neuronal nicotinic receptors in the human brain. Proc Neurobiol. 2000;61:75-111.
3. Shimohama S, Kihara T. Nicotinic receptor-mediated protection against beta-amyloid neurotoxicity. Biol Psychiatry. 2001;49:233-239.
4. Decker MW, Rueter LE, Bitner RS. Nicotinic acetylcholine receptor agonists: a potential new class of analgesics. Curr Top Med Chem. 2004;4:369-384.
5. Buisson B, Bertrand D. Nicotine addiction: the possible role of functional up-regulation. Trends Pharmacol Sci. 2002;23:130-136.
6. Pietila K, Lahde T, Attila M, Ahtee L, Nordberg A. Regulation of nicotinic receptors in the brain of mice withdrawn from chronic oral nicotine treatment. Naunyn Schmiedebergs Arch Pharmacol. 1998;357:176-182.
7. Rowell PP, Li M. Dose-response relationship for nicotine-induced up-regulation of rat brain nicotinic receptors. J Neurochem. 1997;68:1982-1989.
8. Collins AC, Romm E, Wehner JM. Dissociation of the apparent relationship between nicotine tolerance and up-regulation of nicotinic receptors. Brain Res Bull. 1990;25:373-379.
9. Koylu E, Demirgoren S, London ED, Pogun S. Sex difference in up-regulation of nicotinic acetylcholine receptors in rat brain. Life Sci. 1997;61:L185-L190.
10. Perry DC, Davila-Garcia MI, Stockmeier CA, Kellar KJ. Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies. J Pharmacol Exp Ther. 1999;289:1545-1552.
11. Teaktong T, Graham AJ, Johnson M, Court JA, Perry EK. Selective changes in nicotinic acetylcholine receptor subtypes related to tobacco smoking: an immunohistochemical study. Neuropathol Appl Neurobiol. 2004;30:243-254.
12. Kassiou M, Eberl S, Meikle SR, et al. In vivo imaging of nicotinic receptor upregulation following chronic (-)-nicotine treatment in baboon using SPECT. Nucl Med Biol. 2001;28:165-175.
13. Staley JK, Krishnan-Sarin S, Cosgrove KP, et al. Human tobacco smokers in early abstinence have higher of b2* nicotinic acetylcholine receptors than nonsmokers. J Neurosci. 2006;26:8707-8714.
14. 3H]nicotine binding in human postmortem brain. J Pharmacol Exp Ther. 1997;282:7-13.
15. Saji H, Ogawa M, Ueda M, et al. Evaluation of radioiodinated 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine as a ligand for SPECT investigations of brain nicotinic acetylcholine receptors. Ann Nucl Med. 2002;16:189-200.
16. Musachio JL, Scheffel U, Finley PA, et al. 5-[I-125/123]Iodo-3(2(S)- azetidinylmethoxy)pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptors. Life Sci. 1998;62:351-357.
17. 123I]Iodo-A-85380: assessment of pharmacological safety, radiation dosimetry and SPECT imaging of brain nicotinic receptors in healthy human subjects. Ann Nucl Med. 2004;18:337-344.
18. Vaupel DB, Tella SR, Huso DL, et al. Pharmacology, toxicology, and radiation dosimetry evaluation of [I-123]5-I-a-85380, a radioligand for in vivo imaging of cerebral neuronal nicotinic acetylcholine receptors in humans. Drug Dev Res. 2003;58:149-168.
19. 123I-5IA SPECT. J Nucl Med. 2004;45:1458-1470.
20. Marks MJ, Pauly JR, Gross SD, et al. Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J Neurosci. 1992;12:2765-2784.
21. Peng X, Gerzanich V, Anand R, Whiting PJ, Lindstrom J. Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover. Mol Pharmacol. 1994;46:523-530.
22. Marks MJ, Burch JB, Collins AC. Genetics of nicotine response in four inbred strains of mice. J Pharmacol Exp Ther. 1983;226:291-302.
23. Bencherif M, Fowler K, Lukas RJ, Lippiello PM. Mechanisms of up-regulation of neuronal nicotinic acetylcholine receptors in clonal cell lines and primary cultures of fetal rat brain. J Pharmacol Exp Ther. 1995;275:987-994.
24. 3H]l-nicotine in the mouse brain. Life Sci. 1989;44:1123-1132.
25. Muzic R, Berridge M, Friedland R, Zhu N, Nelson A. PET quantification of specific binding of carbon-11-nicotine in human brain. J Nucl Med. 1998;39:2048-2054.
26. Brody AL, Mandelkern MA, London ED, et al. Cigarette smoking saturates brain α4β2 nicotinic acetylcholine receptors. Arch Gen Psychiatry. 2006;63:907-915.
27. Ding Y-S, Volkow ND, Logan J, et al. Occupancy of brain nicotinic acetylcholine receptors by nicotine doses equivalent to those obtained when smoking a cigarette. Synapse. 2000;35:234-237.
28. Collins AC, Bhat RV, Pauly JR, Marks MJ. Modulation of nicotine receptors by chronic exposure to nicotinic agonists and antagonists. Ciba Found Symp. 1990;152:68-82.
29. Marks MJ, Stitzel JA, Collins AC. Time course study of the effects of chronic nicotine infusion on drug response and brain receptors. J Pharmacol Exp Ther. 1985;235:619-628.
30. Collins AC, Marks MJ, Pauly JR. Differential effect of chronic nicotine treatment on nicotinic receptor numbers in various brain regions of mice. J Subst Abuse. 1989;1:273-286.
31. Luetje CW, Patrick J. Both α and β subunits contribute to the agonist sensitivity of neuronal acetylcholine receptors. J Neurosci. 1991;11:837-845.
32. Fenster CP, Rains MF, Noerager B, Quick MW, Lester RAJ. Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine. J Neurosci. 1997;17:5747-5759.
33. Hsu Y-N, Amin J, Weiss DS, Wecker L. Sustained nicotine exposure differentially affects α3β2 and α4β2 neuronal nicotinic receptors expressed in Xenopus oocytes. J Neurochem. 1996;66:667-675.
34. Olale F, Gerznich V, Kurytov A, Wang F, Lindstrom J. Chronic nicotine exposure differentially affects the function of human α3, α4 and α7 neuronal nicotinic receptor subtypes. J Pharmacol Exp Ther. 1997;283:675-683.
35. Peng X, Gerzanich V, Anand R, Wang F, Lindstrom J. Chronic nicotine treatment up-regulates α3 and α7 acetylcholine receptor subtypes expressed by the human neuroblastoma cell line SH-SY5Y. Mol Pharmacol. 1997;51:776-784.