A pitfall of glomerular sieving: Profibrotic and matrix proteins derive from the Bowman's capsule and not the glomerular tuft in rats with renovascular hypertension

Nephrology Dialysis Transplantation

Volumn 22, Issue 10, 2007, Pages 3055-3060

  Steinmetz, O M ^a   Panzer, U ^a   Fehr, S ^a   Meyer Schwesinger, C ^a   Stahl, R A K ^a   Wenzel, U O ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Bowman's capsule; Fibrosis; Glomerular sieving; Glomerular tuft; Microdissection; PAI 1

Indexed keywords

COLLAGEN 1 ALPHA 1; MATRIX PROTEIN; MESSENGER RNA; PAI 1 PROTEIN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BOWMAN CAPSULE; COMPARATIVE STUDY; CONTROLLED STUDY; GLOMERULUS; IN SITU HYBRIDIZATION; LASER MICRODISSECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RENOVASCULAR HYPERTENSION;

ANIMALS; BLOOD PRESSURE; BOWMAN CAPSULE; COLLAGEN TYPE I; GENE EXPRESSION REGULATION; HYPERTENSION, RENOVASCULAR; IN SITU HYBRIDIZATION; KIDNEY GLOMERULUS; MALE; MODELS, BIOLOGICAL; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER;

EID: 36049010088     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm298     Document Type: Article

References (25)

1. Cook WF, Pickering GW. A rapid method for separating glomeruli from rabbit kidney. Nature 1958; 182: 1103-1104
2. Stahl RA, Helmchen U, Paravicini M et al. Glomerular prostaglandin formation in two-kidney, one-clip hypertensive rats. Am J Physiol 1984; 247: F975-F981
3. Wolf G, Schneider A, Wenzel U et al. Regulation of glomerular TGF-beta expression in the contralateral kidney of two-kidney, one-clip hypertensive rats. J Am Soc Nephrol 1998; 9: 763-772
4. Wenzel UO, Wolf G, Jacob et al. Chronic anti-Thy-1 nephritis is aggravated in the non-clipped but not in the clipped kidney of Goldblatt hypertensive rats. Kidney Int 2002; 61: 2119-213
5. Wenzel UO, Wolf F, Jacob I et al. Beneficial and adverse renal and vascular effects of the vasopeptidase inhibitor omapatrilat in renovascular hypertensive rats. Nephrol Dial Transplant 2003; 18: 2005-2013
6. Smeets B, Te Loeke NA, Dijkman HB et al. The parietal epithelial cell: a key player in the pathogenesis of focal segmental glomerulosclerosis in Thy-1.1 transgenic mice. J Am Soc Nephrol 2004; 15: 928-939
7. Wolf G, Schroeder R, Ziyadeh FN et al. Albumin up-regulates the type II transforming growth factor-beta receptor in cultured proximal tubular cells. Kidney Int 2004; 66: 1849-1858
8. Wenzel UO, Helmchen U, Troschau G et al. Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension. Hypertension 1992; 20: 233-241
9. Wenzel U, Schneider A, Valente AJ et al. Monocyte chemoattractant protein-1 mediates monocyte/macrophage influx in anti-thymocyte antibody-induced glomerulonephritis. Kidney Int 1997; 51: 770-776
10. Misra RP. Isolation of glomeruli from mammalian kidneys by graded sieving. Am J Clin Pathol 1972; 58: 135-113
11. Kreisberg JI, Karnovsky MJ. Glomerular cells in culture. Kidney Int 1983; 23: 439-444
12. Yaoita E, Yamamoto T, Saito M et al. Desmin positive cells outgrowing from rat encapsulated glomeruli. Eur J Cell Biol 1991; 54: 140-149
13. Steinmetz O, Sadaghiani S, Panzer U et al. Antihypertensive therapy induces compartment specific chemokine expression and a Th1 immune response in the clipped kidney of Goldblatt hypertensive rats. Am J Physiol 2007; 292: F876-F887
14. Panzer U, Reinking RR, Steinmetz OM et al. CXCR3 and CCR5 positive T-cell recruitment in acute human renal allograft rejection. Transplantation 2004; 78: 1341-1350
15. Panzer U, Steinmetz OM, Reinking RR et al. Compartment-specific expression and function of the chemokine IP-10/CXCL10 in a model of renal endothelial microvascular injury. J Am Soc Nephrol 2006; 17: 454-464
16. Barnes JL, Mitchell RJ, Torres ES. Expression of plasminogen activator-inhibitor-1 (PAI-1) during cellular remodeling in proliferative glomerulonephritis in the rat. J Histochem Cytochem 1995; 43: 895-905
17. Grandaliano G, Gesualdo L, Ranieri E et al. Tissue factor, plasminogen activator inhibitor-1, and thrombin receptor expression in human crescentic glomerulonephritis. Am J Kidney Dis 2000; 35: 726-738
18. Keeton M, Ahn C, Eguchi Y et al. Expression of type 1 plasminogen activator inhibitor in renal tissue in murine lupus nephritis. Kidney Int 1995; 47: 148-157
19. Ma LJ, Nakamura S, Whitsitt JS et al. Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1. Kidney Int 2000; 58: 2425-2436
20. Nakamura S, Nakamura I, Ma L et al. Plasminogen activator inhibitor-1 expression is regulated by the angiotensin type 1 receptor in vivo. Kidney Int 2000; 58: 251-259
21. Yamamoto K, Loskutoff DJ. The kidneys of mice with autoimmune disease acquire a hypofibrinolytic/procoagulant state that correlates with the development of glomerulonephritis and tissue microthrombosis. Am J Pathol 1997; 151: 725-734
22. Dijkman H, Smeets B, Van der Laak J et al. The parietal epithelial cell is crucially involved in human idiopathic focal segmental glomerulosclerosis. Kidney Int 2005; 68: 1562-1572
23. Lei J, Silbiger S, Ziyadeh FN, Neugarten J. Serum-stimulated a1 type IV collagen gene transcription is mediated by TGF-b and inhibited by estradiol. Am J Physiol 1998; 274: F252-F258
24. Kobayashi T, Uehara S, Ikeda T et al. Vitamin D3 up-regulated protein-1 regulates collagen expression in mesangial cells. Kidney Int 2003; 64: 1632-1642
25. Smeets B, Loeke N, Dijkman H et al. The parietal epithelial cell: a key player in the pathogenesis of focal segmental glomerulosclerosis in Thy-1.1transgenic mice. J Am Soc Nephrol 2004; 15: 928-939