The kidneys of mice with autoimmune disease acquire a hypofibrinolytic/procoagulant state that correlates with the development of glomerulonephritis and tissue microthrombosis

American Journal of Pathology

Volumn 151, Issue 3, 1997, Pages 725-734

  Yamamoto, Koji ^a   Loskutoff, David J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; PLASMINOGEN ACTIVATOR INHIBITOR; PROCOAGULANT; THROMBOPLASTIN; UROKINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FIBRIN DEPOSITION; GENE EXPRESSION; GLOMERULONEPHRITIS; IN SITU HYBRIDIZATION; LUPUS ERYTHEMATOSUS NEPHRITIS; MICROTHROMBUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGING; ANIMALS; BRAIN; FEMALE; FIBRIN; IN SITU HYBRIDIZATION; KIDNEY; LIPOPOLYSACCHARIDES; LIVER; LUNG; LUPUS; MICE; MICE, INBRED STRAINS; MYOCARDIUM; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPLEEN; THROMBOPLASTIN; TISSUE DISTRIBUTION; TISSUE PLASMINOGEN ACTIVATOR; URINARY PLASMINOGEN ACTIVATOR;

EID: 0030882822     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Appel GB, Silva FG, Pirani CL, Meltzer JI, Estes D: Renal involvement in systemic lupus erythematosus (SLE): a study of 56 patients emphasizing histologic classification. Medicine 1978, 57:371-410
2. Long AA, Ginsberg JS, Brill-Edwards P, Johnston M, Turner C, Denburg JA, Bensen WG, Cividino A, Andrew M, Hirsh J: The relationship of antiphospholipid antibodies to thromboembolic disease in systemic lupus erythematosus: a cross-sectional study. Thromb Haemost 1991, 66:520-524
3. Hayslett JP, Kashgarian M: Nephropathy of systemic lupus erythematosus. Diseases of the Kidney. Edited by RW Schrier, CW Gottschalk. Boston, Little, Brown and Co, 1993, pp 2019-2037
4. Theofilopoulos AN, Dixon FJ: Murine models of systemic lupus erythematosus. Adv Immunol 1985, 37:269-330
5. Hardin JA, Cronlund M, Haber E, Bloch KJ: Activation of blood clotting in patients with systemic lupus erythematosus. Am J Med 1978, 65:430-436
6. Tipping PG, Dowling JP, Holdsworth SR: Glomerular procoagulant activity in human proliferative glomerulonephritis. J Clin Invest 1988, 81:119-125
7. Kant KS, Pllak VE, Dosekun A: Lupus nephritis with thrombosis and abnormal fibrinolysis: effect of ancrod. J Lab Clin Med 1985, 105: 77-88
8. Kant KS, Pollak VE, Weiss MA, Glueck HI, Miller MA, Hess EV: Glomerular thrombosis in systemic lupus erythematosus: prevalence and significance. Medicine 1981, 60:71-86
9. Watson KV, Schorer AE: Lupus anticoagulant inhibition of in vitro prostacyclin release is associated with a thrombosis-prone subset of patients. Am J Med 1991, 90:47-53
10. Freyssinet J-M, Cazenave J-P: Lupus-like anticoagulants, modulation of the protein C pathway and thrombosis. Thromb Haemost 1987, 58:679-681
11. Keeton M, Eguchi Y, Sawdey M, Ahn C, Loskutoff DJ: Cellular localization of type 1 plasminogen activator inhibitor messenger RNA and protein in murine renal tissue. Am J Pathol 1993, 142:59-70
12. Sappino A-P, Huarte J, Vassalli J-D, Belin D: Sites of synthesis of urokinase and tissue-type plasminogen activators in the murine kidney J Clin Invest 1991, 87:962-970
13. Yamamoto K, Loskutoff DJ: Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator. J Clin Invest 1996, 97:2440-2451
14. Oliver A, Barcelo P, Fernandez C, Rousand F, Lopez O, Ballarin JA, Calero F: Increased levels of plasminogen activator inhibitor in nephrotic syndrome. Kidney Int 1990, 37:1590
15. Bergstein JM, Riley M, Bang NU: Role of plasminogen-activator inhibitor type 1 in the pathogenesis and outcome of the hemolytic uremic syndrome. N Engl J Med 1992, 37:755-759
16. Angles-Cano E, Sultan Y, Clauvel J-P: Predisposing factors to thrombosis in systemic lupus erythematosus: possible relation to endothelial cell damage. J Lab Clin Med 1979, 94:312-323
17. Glas-Greenwalt P, Kant KS, Allen C, Pollak VE: Fibrinolysis in health and disease: severe abnormalities in systemic lupus erythematosus. J Lab Clin Med 1984, 104:962-976
18. Awada H, Barlowatz-Meimon G, Dougados M, Maisonneuve P, Sultan Y, Amor B: Fibrinolysis abnormalities in systemic lupus erythematosus and their relation to vasculitis. J Lab Clin Med 1988, 111:229-236
19. Violi F, Ferro D, Valesini G, Quintarelli C, Saliola M, Grandilli MA, Balsano F: Tissue plasminogen activator inhibitor in patients with systemic lupus erythematosus and thrombosis. Br Med J 1990, 300: 1099-1102
20. Keeton M, Ahn C, Eguchi Y, Burlingame R, Loskutoff DJ: Expression of type 1 plasminogen activator inhibitor in renal tissue in murine lupus nephritis. Kidney Int 1995, 47:148-157
21. Troyer DA, Chandrasekar B, Thinnes T, Stone A, Loskutoff DJ, Fernandes G: Effects of energy intake on type 1 plasminogen activator inhibitor levels in glomeruli of lupus-prone B/W mice. Am J Pathol 1995, 146:111-120
22. Edgington TS, Mackman N, Brand K, Ruf W: The structural biology of expression and function of tissue factor. Thromb Haemost 1991, 66:67-79
23. Holdsworth SR, Tipping PG: Macrophage-induced glomerular fibrin deposition in experimental glomerulonephritis in the rabbit. J Clin Invest 1985, 76:1367-1374
24. Tipping PG Holdsworth SR: The participation of macrophages, glomerular procoagulant activity, and factor VIII in glomerular fibrin deposition: studies in anti-glomerular basement membrane antibody induced glomerulonephritis in rabbits. Am J Pathol 1986, 124:10-17
25. Tipping PG, Lowe MG, Holdsworth SR: Glomerular macrophages express augmented procoagulant activity in experimental glomerulonephritis in rabbits. J Clin Invest 1988, 82:1253-1259
26. Tipping PG, Erlich JH, Apostolopoulos J, Mackman N, Loskutoff D, Holdsworth SR: Glomerular tissue factor expression in crescentic glomerulonephritis: correlations between antigen, activity, and mRNA. Am J Pathol 1995, 147:1736-1748
27. Thomson NM, Moran J, Simpson IJ, Peters DK: Defibrination with ancrod in nephrotoxic nephritis in rabbits. Kidney Int 1976, 10:343-347
28. Tipping PG, Thomson NM, Holdsworth S: A comparison of fibrinolytic and defibrinating agents in established experimental glomerulonephritis. Br J Exp Pathol 1986, 67:481-491
29. Datta SK: Murine lupus. Methods Enzymol 1988, 162:385-412
30. Schleef RR, Sinha M, Loskutoff DJ: Immunoradiometric assay to measure the binding of a specific inhibitor to tissue-type plasminogen activator. J Lab Clin Med 1985, 106:408-415
31. Samad F, Yamamoto K, Loskutoff DJ: Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo: induction by tumor necrosis factor-α and lipopolysaccharide. J Clin Invest 1996,97:37-46
32. Olman MA, Mackman N, Gladson CL, Moser KM, Loskutoff DJ: Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse. J Clin Invest 1995, 96:1621-1630
33. Barnes JL, Mitchell RJ, Torres ES: Expression of plasminogen activator-inhibitor-1 (PAI-1) during cellular remodeling in proliferative glomerulonephritis in the rat. J Histochem Cytochem 1995, 43:895-905
34. Moll S, Menoud PA, Fulpius T, Pastore Y, Takahashi S, Fossati L, Vassalii JD, Sappino AP, Schifferli JA, Izui S: Induction of plasminogen activator inhibitor type 1 in murine lupus-like glomerulonephritis. Kidney Int 1995, 48:1459-1468
35. Levine S, Deegan MJ, Futrell N, Welch KMA: Cerebrovascular and neurological disease associated with antiphospholipid antibodies: 48 cases. Neurology 1990, 40:1181-1189
36. Cole EH, Schulman J, Urowitz M: Monocyte procoagulant activity in glomerulonephritis associated with systemic lupus erythematosus. J Clin Invest 1985, 75:861-868
37. Cole EH, Sweet J, Levy GA: Expression of macrophage procoagulant activity in murine systemic lupus erythematosus. J Clin Invest 1986, 78:887-893
38. Tipping PG, Leong TW, Holdsworth SR: The contribution of macrophages to glomerular tumor necrosis factor production in anti-GBM glomerulonephritis in rabbits. Lab Invest 1991, 65:21272-2279
39. Tipping PG, Lowe MG, Holdsworth SR: Glomerular interleukin-1 production is dependent on macrophage infiltration in anti-GBM glomerulonephritis. Kidney Int 1991, 39:103-110
40. Tsumagari T, Tanaka K: Effects of fibrinogen degradation products on glomerular mesangial cells in culture. Kidney Int 1984, 26:712-718
41. Smith HR, Hansen CL, Rose R, Canoso RT: Autoimmune MRL-lpr/lpr mice are an animal model for the secondary antiphospholipid syndrome. J Rheumatol 1990, 17:911-915