Sinus fluid penetration of oral clarithromycin and azithromycin in patients with acute rhinosinusitis

American Journal of Rhinology

Volumn 21, Issue 5, 2007, Pages 574-578

  Margaritis, Vasilios K ^a,b   Ismailos, George S ^a   Naxakis, Stefanos S ^a   Mastronikolis, Nicholas S ^a   Goumas, Panos D ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY HOSPITAL OF PATRAS   (Greece)

Author keywords

Antibiotics; Azithromycin; Chromatography; Clarithromycin; Concentration; Penetration; Resistance; Rhinosinusitis; Sinus; Therapy

Indexed keywords

AZITHROMYCIN; CLARITHROMYCIN;

ACUTE DISEASE; ADULT; ARTICLE; ASPIRATION; BACTERIAL INFECTION; BITTER TASTE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG PENETRATION; DRUG TISSUE LEVEL; FEMALE; HEADACHE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; NAUSEA; NOSE SECRETION; PARANASAL SINUS; PH; RHINOSINUSITIS; SIDE EFFECT; STREPTOCOCCUS PNEUMONIAE;

ACUTE DISEASE; ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; BODY FLUIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLARITHROMYCIN; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MIDDLE AGED; RHINITIS; SINUSITIS; SPECTROMETRY, FLUORESCENCE; TIME FACTORS;

EID: 36048988024     PISSN: 10506586     EISSN: None     Source Type: Journal    
DOI: 10.2500/ajr.2007.21.3071     Document Type: Article

References (25)

1. Slavin RG, Spector SL, and Bernstein LI. The diagnosis and management of sinusitis: A practice parameter update. J Allergy Clin Immunol 116(suppl 6):S13-S47, 2005.
2. Antimicrobial treatment guidelines for acute bacterial rhinosinusitis. Sinus and Allergy Health Partnership. Otolaryngol Head Neck Surg 123:5-31, 2000.
3. Pichichero ME, and Brixner DI. A review of recommended antibiotic therapies with impact on outcomes in acute otitis media and acute bacterial sinusitis. Am J Manag Care 12:S292-S302, 2006.
4. Abad-Santos F, Galvez-Mugica MA, Espinosa de los Monteras MJ, et al. Meta-analysis of clarithromycin compared with other antimicrobials in the treatment of upper respiratory tract infections. Rev Esp Quimioter 16:313-324, 2003.
5. Ioannidis JP, Contopoulos DG, Chew P, and Lau J. Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for upper respiratory tract infections. J Antimicrob Chemother 48:677-689, 2001.
6. Goumas P, Naxakis S, Bassaris C, and Skoutelis A. Comparative efficacy and tolerability of clarithromycin and cefaclor in the treatment of outpatients with acute maxillary sinusitis. Clin Drug Invest 13:128-133, 1997.
7. Klapan I, Culig J, Oreskovic K, et al. Azithromycin versus amoxicillin/clavulanate in the treatment of acute sinusitis. Am J Otolaryngol 20:7-11, 1999.
8. Rechtweg JS, Moinuddin R, Houser SM, et al. Quality of life in treatment of acute rhinosinusitis with clarithomycin and amoxicillin/clavulanate. Laryngoscope 114:806-811, 2004.
9. Cervin A, and Wall work B. Anti-inflammatory effects of macrolide antibiotics in the treatment of chronic rhinosinusitis. Otolaryngol Clin North Am 38:1339-1350, 2005.
10. Majima Y. Clinical implications of the immunomodulatory effects of macrolides on sinusitis. Am J Med 117:20S-25S, 2004.
11. Wallwork B, Coman W, Mackay-Sim A, et al. A double-blind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis. Laryngoscope 116:189-193, 2006.
12. Bishai WR. Macrolide immunomodulatory effects and symptom resolution in acute exacerbation of chronic bronchitis and acute maxillary sinusitis: A focus on clarithromycin. Expert Rev Anti Infect Ther 4:405-416, 2006.
13. Muller M, dela Pena, and Derendorf H. Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: Distribution in tissue. Antimicrob Agents Chemother 48:1441-1453, 2004.
14. Scaglione F, Pintucci J, Tassi F, et al. Penetration of clarithromycin into oral and respiratory tissues. Drug Invest 6:104-109, 1993.
15. Karma P, Pukander J, and Penttila M. Azithromycin concentrations in sinus fluid and mucosa after oral administration. Eur J Microbiol Infect Dis 10:856-859, 1991.
16. Kuehnel TS, Schur C, Lotter K, and Kees F. Penetration of telithromycin into the nasal mucosa and ethmoid bone of patients undergoing rhinosurgery for chronic sinusitis. J Antimicrob Chemother 55:591-594, 2005.
17. Kropec A, Schmidt-Eisenlohr E, and Daschner F. Concentrations of roxithromycin in serum and in sinus mucosa. Infection 16:250-254, 1988.
18. Sastre Torano J, and Guchelaar HJ. Quantitative determination of the macrolide antibiotics erythromycin, roxithromycin, azithromycin and clarithromycin in human serum by HPLC using pre-column derivization with 9-fluorenylmethyloxycarbonyl choline and fluorescence detection. J Chromatogr B 720:89-97, 1998.
19. Liapakis I, Light R, Pitiakoudis M, et al. Penetration of clarithromycin in experimental pleural empyema model fluid. Respiration 72:296-300, 2005.
20. Rodvold KA. Clinical pharmacokinetics of clarithromycin. Clin Pharmacokinet 37:385-398, 1999.
21. Hoffler D, Koeppe P, and Paeske B. Pharmacokinetics of azithromycin in normal and impaired renal function. Infection 23:356-361, 1995.
22. Patel KB, Xuan D, Tessier PR, et al. Comparison of broncho-pulmonary pharmacokinetics of clarithromycin and azithromycin. Antimicrob Agents Chemother 40:2375-2379, 1996.
23. Dalhoff A, Schubert S, and Ullman U. Effect of pH on the in vitro activity of and propensity for emergence of resistance to fluoroquinolones, macrolides, and a ketolide. Infection 33(suppl 2):36-43, 2005.
24. Barry AL, Jones RN, and Thornsberry C. In vitro activities of azithromycin (CP 62993), clarithromycin (A-56268; TE-031), erythromycin, roxithromycin, and clindamycin. Antimicrob Agents Chemother 32:752-754, 1988.
25. Zhanel GG, Walters M, Noreddin A, et al. The ketolides. Crit Rev Drugs 62:1771-1804, 2002.