Urinary neutrophil gelatinase-associated lipocalcin in D+HUS: A novel marker of renal injury

Pediatric Nephrology

Volumn 21, Issue 7, 2006, Pages 989-994

  Trachtman, Howard ^a   Christen, Erica ^a   Cnaan, Avital ^b   Patrick, Jilma ^c   Mai, Volker ^c   Mishra, Jaya ^d   Jain, Aditya ^d   Bullington, Nathan ^d   Devarajan, Prasad ^d  

^a SCHNEIDER CHILDREN'S HOSPITAL   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Acute renal failure; Biomarker; Dialysis; Diarrhea associated hemolytic uremic syndrome (D+HUS); Neutrophil gelatinase associated lipocalcin (NGAL)

Indexed keywords

BIOLOGICAL MARKER; CREATININE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALCIN; NITROGEN; PLACEBO; SYNSORB PK; UNCLASSIFIED DRUG; UREA; URINARY TRACT AGENT;

ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIALYSIS; DIARRHEA; DISEASE ASSOCIATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; ENZYMURIA; HEMOLYTIC UREMIC SYNDROME; HOSPITALIZATION; HUMAN; KIDNEY INJURY; KIDNEY TUBULE DAMAGE; KIDNEY TUBULE EPITHELIUM; PATIENT SELECTION; PREDICTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; UREA NITROGEN BLOOD LEVEL; URINALYSIS; URINARY EXCRETION;

ACUTE-PHASE PROTEINS; ADOLESCENT; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; DIARRHEA; DOUBLE-BLIND METHOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEMOLYTIC-UREMIC SYNDROME; HUMANS; INFANT; KIDNEY FAILURE; LIPOCALINS; MALE; PROTO-ONCOGENE PROTEINS; RENAL INSUFFICIENCY;

EID: 33745108383     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-006-0146-y     Document Type: Article

References (20)

1. Trachtman H, Christen C (1999) Hemolytic uremic syndrome: Current understanding of the pathogenesis and therapeutic trials and interventions. Curr Opin Pediatr 11:162-168
2. Tarr PI, Gordon CA, Chandler WL (2005) Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet 365:1073-1086
3. Kaplan BA, Meyers KE, Schulman S (1998) The pathogenesis and treatment of hemolytic uremic syndrome. J Am Soc Nephrol 9:1126-1133
4. Andreoli SP, Trachtman H, Acheson DWK, Siegler RL, Obrig TG (2002) Hemolytic uremic syndrome: Epidemiology, pathophysiology, and therapy. Pediatr Nephrol 17:293-298
5. Trachtman H, Cnaan A, Christen E, Gibbs K, Zhao S, Acheson DWK, Weiss R, Kaskel FJ, Spitzer A, Hirschman GH (2003) Effect of an oral Shiga toxin-binding agent on diarrhea-associated hemolytic uremic syndrome in children: A randomized clinical trial. JAMA 290:1337-1344
6. Siegler RL (1994) Spectrum of extra-renal involvement in postdiarrheal hemolytic-uremic syndrome. J Pediatr 125:511-518
7. Garg AX, Suri RS, Barrowman N, Rehman F, Matsell D, Rosas-Arellano MP, Salvadori M, Haynes RB, Clark WF (2003) Long-term renal prognosis of diarrhea-associated hemolytic uremic syndrome: A systematic review, meta-analysis, and meta-regression. JAMA 290:1360-1370
8. Ray PE, Liu XH (2001) Pathogenesis of Shiga toxin-induced hemolytic uremic syndrome. Pediatr Nephrol 16:823-839
9. Kiyokawa N, Taguchi T, Mori T, Uchida H, Sato N, Takeda T, Fujimoto J (1998) Induction of apoptosis in normal renal tubular epithelial cells by Escherichia coli Shiga toxins 1 and 2. J Infect Dis 178:178-184
10. Hughes AK, Stricklett PK, Kohan DE (1998) Cytotoxic effect of Shiga toxin-1 on human proximal tubule cells. Kidney Int 54:426-437
11. Noris M, Remuzzi G (2005) Hemolytic uremic syndrome. J Am Soc Nephrol 16:1035-1050
12. Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J, Barasch J, Devarajan P (2003) Identification of neutrophil gelatinase-associated lipocalcin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14:2534-2543
13. Mishra J, Mori K, Ma Q, Kelly C, Yang J, Mitsnefes M, Barasch J, Devarajan P (2004) Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalcin. J Am Soc Nephrol 15:3073-3082
14. Mori K, Lee HT, Rapoport D, Drexler IR, Foster K, Yang J, Schmidt-Ott KM, Chen X, Li JY, Mishra J, Cheema FH, Markowitz G, Suganami T, Sawai K, Mukoyama M, Kunis C, D'Agati V, Devarajan P, Barasch J (2005) Endocytic delivery of lipocalcin-siderophore-iron complex rescues the kidney ischemia-reperfusion injury. J Clin Invest 115:610-621
15. Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P (2005) Neutrophil gelatinase-associated lipocalcin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365:1231-1238
16. Te Loo DM, Monnens LA, van den Heuvel LP, Gubler MC, Kockx MM (2001) Detection of apoptosis in kidney biopsies of patients with D+ hemolytic uremic syndrome. Pediatr Res 49:413-416
17. Nestoridi E, Kushak RI, Duguerre D, Grabowski EF, Ingelfinger JR (2005) Up-regulation of tissue factor activity on human proximal tubular epithelial cells in response to Shiga toxin. Kidney Int 67:2254-2266
18. Schulman SL, Kaplan BS (1996) Management of patients with hemolytic uremic syndrome demonstrating severe azotemia but not anuria. Pediatr Nephrol 10:671-674
19. Lameire N, Van Biesen W, Vanholder R (2005) Acute renal failure. Lancet 365:417-430
20. Ohlsson S, Wieslander J, Segelmark M (2003) Increased circulating levels of proteinase 3 in patients with anti-neutrophilic cytoplasmic autoantibodies-associated systemic vasculitis in remission. Clin Exp Immunol 131:528-535