Management of xerostomia in older patients: A randomised controlled trial evaluating the efficacy of a new oral lubricant solution

Drugs and Aging

Volumn 24, Issue 11, 2007, Pages 957-965

  Mouly, Stéphane ^a   Salom, Michel ^b   Tillet, Yves ^c   Coudert, Anne Claude ^d   Oberli, Frantz ^e   Preshaw, Philip M ^f   Desjonquères, Stéphane ^d   Bergmann, Jean François ^a  

^a HÔPITAL LARIBOISIÈRE   (France)

^b Clinique Leopold Bellan   (France)

^c White Tillet Consultants and Experts   (France)

^d Laboratoires Carilène   (France)

^e Dermscan Pharmscan   (France)

^f NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Elderly; Glycerol, therapeutic use; Saliva; Xerostomia, treatment

Indexed keywords

LUBRICATING AGENT; OXYGENATED GLYCEROL TRIESTER; SALIVA SUBSTITUTE; UNCLASSIFIED DRUG;

AEROSOL; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; INSTITUTIONAL CARE; MALE; MOUTH MUCOSA; MUCOSA INFLAMMATION; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; TASTE; VISUAL ANALOG SCALE; XEROSTOMIA;

EID: 36048963387     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-200724110-00007     Document Type: Article

References (31)

1. Navazesh M, Denny P, Sobel S. Saliva: a fountain of opportunity. J Calif Dent Assoc 2002; 30: 783-8
2. Mason DK, Chishlom DM. Salivary glands and their secretions. In: Mason DK, Chishlom DM, editors. Salivary glands in health and disease. London: Saunders, 1975: 3-69
3. Wilborn WH, Schackleford JM. Microanatomy of human salivary glands. In: Manaken L, editor. The biologic basis of dental caries. Hagerstown: Harper & Row, 1980: 3-62
4. Madinier I, Jehl-Pietri C, Monteil RA. Les hyposialies d'origine medicamenteuse. Ann Med Int 1997; 148: 398-405
5. Handelman SL, Baric JM, Espeland MA, et al. Prevalence of drugs causing hyposalivation in an institutionalized geriatric population. Oral Surg Oral Med Oral Pathol 1986; 62: 26-31
6. Hendelman SL, Baric JM, Saunders RH, et al. Hyposalivary drug use, whole stimulated salivary flow and mouth dryness in older long-term care residents. Spec Care Dent 1989; 1: 12-8
7. Mornstad H, Von Knorring L, Forsgren L, et al. Long-term effects of two principally different antidepressant drugs on saliva secretion and composition. Scand J Dent Res 1986; 94: 461-70
8. Sreeby LM, Valdini A, Yu A. Xerostomia: part II. Relationship to nonoral symptoms, drugs, and diseases. Oral Surg Oral Med Anti Oral Pathol 1989; 68: 419-27
9. Fox PC. Management of dry mouth. Dent Clin North Am 1997; 41: 863-75
10. Matear DW, Locker D, Stephens M, et al. Associations between xerostomia and health status indicators in the elderly. J R Soc Health 2006; 126: 79-85
11. Rejnefelt I, Andersson P, Renvert S. Oral health status in individuals with dementia living in special facilities. Int J Dent Hyg 2006; 4: 67-71
12. Locker D. Xerostomia in older adults: a longitudinal study. Gerodontology 1995; 12: 18-25
13. Peltola P, Vehkalahti MM, Wuolijoki-Saaristo K. Oral health and treatment needs of the long-term hospitalized elderly. Gerodontology 2004; 21: 93-9
14. Sreenby LM, Valdini A. Xerostomia: a neglected symptom. Arch Int Med 1987; 147: 1333-7
15. Guijarro Guijarro B, Lopez Sanchez AF, Hernandez Vallejo G. Treatment of xerostomia: a review. Med Oral 2001; 6: 7-18
16. Navazesh M. Dry mouth: aging and oral health. Compend Contin Educ Dent 2002; 23: 41-8
17. Andersson G, Johansson G, Attstrom R, et al. Comparison of the effect of the linseed extract salinum and a methyl cellulose preparation on the symptoms of dry mouth. Gerodontology 1995; 12: 12-7
18. Niedermeier W, Huber M, Fischer D, et al. Significance of saliva for the denture-wearing population. Gerodontology 2000; 17: 104-18
19. Epstein JB, Emerton S, Le ND, et al. A open-labelled crossover trial of oral balance gel and biotene toothpaste versus placebo in patients with xerostomia following radiation therapy. Oral Oncol 1999; 35: 132-7
20. Navazesh M, ADA Council on Scientific Affairs and Division of Science. How can oral health care providers determine if patients have dry mouth? J Am Dent Assoc 2003; 134: 613-20; quiz 633
21. Epstein JB, Scully C. The role of saliva in oral health and the causes and effects of xerostomia. J Can Dent Assoc 1992; 58: 217-21
22. Vered M, Buchner A, Boldon P, et al. Age-related histomorphometric changes in labial salivary glands with special reference to the acinar component. Exp Gerontol 2000; 35: 1075-84
23. Moreira CR, Azevedo LR, Lauris JR, et al. Quantitative age-related differences in human sublingual gland. Arch Oral Biol 2006; 51: 960-6
24. Nyarady Z, Nemeth A, Ban A, et al. A randomized study to assess the effectiveness of orally administered pilocarpine during and after radiotherapy of head and neck cancer. Anticancer Res 2006; 26: 1557-62
25. Sweeney MP, Bagg J, Baxter WP, et al. Clinical trial of a mucin-containing oral spray for treatment of xerostomia in hospice patients. Palliat Med 1997; 11: 225-32
26. Davies AN. A comparison of artificial saliva and chewing gum in the management of xerostomia in patients with advanced cancer. Palliat Med 2000; 14: 197-203
27. Moritsuka M, Kitasako Y, Burrow MF, et al. Quantitative assessment for stimulated saliva flow rate and buffering capacity in relation to different ages. J Dent 2006; 34: 716-20
28. Davies AN, Daniels C, Pugh R, et al. A comparison of artificial saliva and pilocarpine in the management of xerostomia in patients with advanced cancer. Palliat Med 1998; 12: 105-11
29. Navazesh M, Christensen C, Brightman V. Clinical criteria for the diagnosis of salivary hypofunction. J Dent Res 1992; 71: 1363-9
30. Meyer-Lueckel H, Kielbassa AM. Utilisation de succedanes salivaires chez les patients souffrant de xerostomie. Rev Mens Suisse Odontostomatol 2002; 112: 1049-58
31. Navazesh M. Xerostomia in the aged. Dent Clin North Am 1989; 33: 75-80