SKY reveals a high frequency of unbalanced translocations involving chromosome 6 in t(12;21)-positive acute lymphoblastic leukemia

Leukemia Research

Volumn 32, Issue 1, 2008, Pages 39-43

  Betts, David R ^a   Stanchescu, Racheli ^b   Niggli, Felix K ^a   Cohen, Ninette ^b   Rechavi, Gideon ^b   Amariglio, Ninette ^b   Trakhtenbrot, Luba ^b  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b SHEBA MEDICAL CENTER   (Israel)

Author keywords

Acute lymphoblastic leukemia; Child; Karyotyping; SKY

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CHILD; CHROMOSOME 12P; CHROMOSOME 21Q; CHROMOSOME TRANSLOCATION 12; CHROMOSOME TRANSLOCATION 21; CHROMOSOME TRANSLOCATION 6; CLINICAL ARTICLE; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; SPECTRAL KARYOTYPING;

CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CHROMOSOME BANDING; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 21; CHROMOSOMES, HUMAN, PAIR 6; FEMALE; HUMANS; MALE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; SPECTRAL KARYOTYPING; TRANSLOCATION, GENETIC;

EID: 36048959170     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2007.03.010     Document Type: Article

References (19)

1. Loh M.L., and Rubnitz J.E. TEL/AML1-positive pediatric leukemia: prognostic significance and therapeutic approaches. Curr Opin Hematol 9 (2002) 345-352
2. Raynaud S.D., Dastugue N., Zoccola D., Shurtleff S.A., Mathew S., and Raimondi S.C. Cytogenetic abnormalities associated with the t(12;21): a collaborative study of 169 children with t(12;21)-positive acute lymphoblastic leukemia. Leukemia 13 (1999) 1325-1330
3. Schrock E., du Manoir S., Veldman T., Schoell B., Wienberg J., Ferguson-Smith M.A., et al. Multicolor spectral karyotyping of human chromosomes. Science 273 (1996) 494-497
4. Schrock E., Veldman T., Padilla-Nash H., Ning Y., Spurbeck J., Jalal S., et al. Spectral karyotyping refines cytogenetic diagnostics of constitutional chromosomal abnormalities. Hum Genet 101 (1997) 255-262
5. Cohen N., Betts D.R., Trakhtenbrot L., Niggli F.K., Amariglio N., Brok-Simoni F., et al. Detection of unidentified chromosome abnormalities in human neuroblastoma by spectral karyotyping (SKY). Genes Chromosomes Cancer 31 (2001) 201-208
6. Cohen N., Betts D.R., Tavori U., Toren A., Ram T., Constantini S., et al. Karyotypic evolution pathways in medulloblastoma/primitive neuroectodermal tumor determined with a combination of spectral karyotyping, G-banding, and fluorescence in situ hybridization. Cancer Genet Cytogenet 149 (2004) 44-52
7. Nordgren A., Heyman M., Sahlen S., Schoumans J., Soderhall S., Nordenskjold M., et al. Spectral karyotyping and interphase FISH reveal abnormalities not detected by conventional G-banding. Eur J Haematol 68 (2002) 31-41
8. ISCN. In: Mitelman F, editor. An international system for cytogenetic nomenclature. Basel: S Karger; 1995.
9. Karst C., Gross M., Haase D., Wedding U., Hoffken K., Liehr T., et al. Novel cryptic chromosomal rearrangements detected in acute lymphoblastic leukemia detected by application of new multicolor fluorescent in situ hybridization approaches. Int J Oncol 28 (2006) 891-897
10. Offit K., Parsa N.Z., Gaidano G., Filippa D.A., Louie D., Pan D., et al. 6q deletions define distinct clinico-pathologic subsets of non-Hodgkin's lymphoma. Blood 82 (1993) 2157-2162
11. Wong K.F., Chan J.K., and Kwong Y.L. Identification of del(6)(q21q25) as a recurring chromosomal abnormality in putative NK cell lymphoma/leukaemia. Br J Haematol 98 (1997) 922-926
12. Mancini M., Vegna M.L., Castoldi G.L., Mecucci C., Spirito F., Elia L., et al. Partial deletions of long arm of chromosome 6: biologic and clinical implications in adult acute lymphoblastic leukemia. Leukemia 16 (2002) 2055-2061
13. Burkhard B., Bruch J., Zimmermann M., Strauch K., Parwaresch R., Ludwig W.-D., et al. Loss of heterozygosity on chromosome 6q14-q24 is associated with poor outcome in children and adolescents with T-cell lymphoblastic lymphoma. Leukemia 20 (2006) 1422-1429
14. Kempski H., Chalker J., Chessells J., Sturt N., Brickell P., Webb J., et al. An investigation of the t(12;21) rearrangement in children with B-precursor acute lymphoblastic leukemia using cytogenetic and molecular methods. Br J Haematol 105 (1999) 684-689
15. Attarbaschi A., et al. Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis. Leukemia 18 (2004) 1611-1616
16. Crowley J.A., Butler M.S., Ronnenburg M.J., Ament C.N., Meekins J.S., and Ning Y. Development of a dual-color fluorescence in situ hybridization probe set on chromosome 6q to improve cytogenetic diagnosis of lymphoid malignancies. Cancer Genet Cytogenet 157 (2005) 78-81
17. Elghezal H., Le Guyader G., Radford-Weiss I., Perot C., Van Den Akker J., Eydoux P., et al. Reassessment if childhood B-lineage lymphoblastic leukemia karyotypes using spectral analysis. Genes Chromosomes Cancer 30 (2001) 383-392
18. Lu X.Y., Harris C.P., Cooley L., Margolin J., Steuber P.C., Sheldon M., et al. The utility of spectral karyotyping in the cytogenetic analysis of newly diagnosed pediatric acute lymphoblastic leukemia. Leukemia 16 (2002) 2222-2227
19. Martineau M., Reza Jalali G., Barber K.E., Broadfield Z.J., Cheung K.L., Lilleyman J., et al. ETV6/RUNX1 fusion at diagnosis and relapse: some prognostic indications. Genes Chromosomes Cancer 43 (2005) 54-71