Family history, early adversity and the hypothalamic-pituitary-adrenal (HPA) axis: Mediation of the vulnerability to mood disorders

Neuropsychiatric Disease and Treatment

Volumn 3, Issue 5, 2007, Pages 647-653

  Watson, Stuart ^a   Owen, Bruce M ^a   Gallagher, Peter ^a   Hearn, Andrea J ^a   Young, Allan H ^a   Ferrier, I Nicol ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Bipolar disorder; Childhood trauma; Chronic depression; Cortisol; Family history

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; CARBAMAZEPINE; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; GABAPENTIN; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; LAMOTRIGINE; LITHIUM SALT; MIANSERIN; MIRTAZAPINE; NEUROLEPTIC AGENT; REBOXETINE; SEROTONIN UPTAKE INHIBITOR; TRAZODONE; TRYPTOPHAN; VALPROIC ACID; VENLAFAXINE;

ADULT; ARTICLE; BIPOLAR DISORDER; CHILD ABUSE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FAMILY HISTORY; FEEDBACK SYSTEM; FEMALE; GENETIC SUSCEPTIBILITY; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LIFE EVENT; MAJOR DEPRESSION; MALE; MOOD DISORDER; PATHOPHYSIOLOGY; PERSONAL EXPERIENCE; QUESTIONNAIRE;

EID: 36048949270     PISSN: 11766328     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Bernstein DP, Fink L. 1998. Manual for the Childhood Trauma Questionnaire: a retrospective self-report. The Psychological Corporation, Harcourt Brace, San Antonio.
2. Bremner JD, Vythilingam M, Vermetten E, et al. 2003. Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse. Psychoneuroendocrinology, 28:733-50.
3. Brown GR, McBride L, Bauer MS, et al. 2005. Impact of childhood abuse on the course of bipolar disorder: A replication study in U.S. veterans. Journal of Affective Disorders, 89:57-67.
4. Brown GW, Harris T. 1978. Social origins of depression: a study of psychiatric disorder in women. London: Tavistock.
5. Carroll BJ. 1982. The dexamethasone suppression test for melancholia. British Journal of Psychiatry, 140:292-304.
6. Gallagher P, Watson S, Smith MS, et al. 2007. Plasma cortisol-dehydro-epiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder. Schizophrenia Research, 90:258-65.
7. Garno JL, Goldberg JF, Ramirez PM, et al. 2005. Impact of childhood abuse on the clinical course of bipolar disorder. British Journal of Psychiatry, 186:121-5.
8. Geller B, Tillman R, Craney JL, et al. 2004. Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype. Archives of General Psychiatry, 61:459-67.
9. Glaser D. 2002. Emotional abuse and neglect (psychological maltreatment): a conceptual framework. Child Abuse & Neglect, 26:697-714.
10. Griffin MG, Resick PA, Yehuda R. 2005. Enhanced cortisol suppression following dexamethasone administration in domestic violence survivors. American Journal of Psychiatry, 162:1192-9.
11. Heim C, Nemeroff CB. 2001. The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biological Psychiatry, 49:1023-39.
12. Heim C, Newport DJ, Bonsall R, et al. 2001. Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. American Journal of Psychiatry, 158:575-81.
13. Heim C, Newport DJ, Heit S, et al. 2000. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA, 284:592-7.
14. Heuser I, Yassouridis A, Holsboer F. 1994. The combined dexamethasone/ CRH test: a refined laboratory test for psychiatric disorders. Journal of Psychiatric Research, 28:341-56.
15. Holsboer F. 2002. Neuroendocrinology of mood disorders. In Davis KL, C.D., Coyle JT, et al. Ed., Neuropsychopharmacology: the fourth generation of progess. Lippincott, Williams and Wilkins, Philadelphia, PA.
16. Holsboer F, Lauer CJ, Schreiber W, et al. 1995. Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders. Neuroendocrinology, 62:340-7.
17. Kendler KS, Bulik CM, Silberg J, et al. 2000. Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis. Archives of General Psychiatry, 57:953-9.
18. Ladd CO, Huot RL, Thrivikraman KV, et al. 2004. Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation. Biological Psychiatry, 55:367-75.
19. Lauer CJ, Schreiber W, Modell S, et al. 1998. The Munich vulnerability study on affective disorders: overview of the cross-sectional observations at index investigation. Journal of Psychiatric Research, 32:393-401.
20. Lee R, Geracioti TD Jr, Kasckow JW, et al. 2005. Childhood trauma and personality disorder: positive correlation with adult CSF corticotropin-releasing factor concentrations. American Journal of Psychiatry, 162:995-7.
21. Lightman SL, Windle RJ, Ma XM, et al. 2002. Hypothalamic-pituitary-adrenal function. Archives of Physiology and Biochemistry, 110:90-3.
22. MacMillan HL, Fleming JE, Streiner DL, et al. 2001. Childhood abuse and lifetime psychopathology in a community sample. American Journal of Psychiatry, 158:1878-83.
23. Matsubara T, Funato H, Kobayashi A, et al. 2006. Reduced glucocorticoid receptor [alpha] expression in mood disorder patients and first-degree relatives. Biological Psychiatry, 59:689-95.
24. McQuade R, Young AH. 2000. Future therapeutic targets in mood disorders: the glucocorticoid receptor. British Journal of Psychiatry, 177:390-5.
25. Modell S, Lauer CJ, Schreiber W, et al. 1998. Hormonal response pattern in the combined DEX-CRH test is stable over time in subjects at high familial risk for affective disorders. Neuropsychopharmacology, 18:253-62.
26. Newport DJ, Heim C, Bonsall R, et al. 2004. Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse. Biological Psychiatry, 55:10-20.
27. Paivio SC, Cramer KM. 2004. Factor structure and reliability of the Childhood Trauma Questionnaire in a Canadian undergraduate student sample. Child Abuse & Neglect, 28:889-904.
28. Pariante CM, Miller AH. 2001. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biological Psychiatry, 49:391-404.
29. Perlman WR, Webster MJ, Kleinman JE, et al. 2004. Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness. Biological Psychiatry, 56:844-52.
30. Roy A. 2002. Self-rated childhood emotional neglect and CSF monoamine indices in abstinent cocaine-abusing adults: possible implications for suicidal behavior. Psychiatry Research, 112:69-75.
31. Rush AJ, Giles DE, Schlesser MA, et al. 1996. The dexamethasone suppression test in patients with mood disorders. Journal of Clinical Psychiatry, 57:470-84.
32. Rybakowski JK, Twardowska K. 1999. The dexainethasone/ corticotropin-releasing hormone test in depression in bipolar and unipolar affective illness. Journal of Psychiatric Research, 33:363-70.
33. Sadowski H, Ugarte B, Kolvin I, et al. 1999. Early life family disadvantages and major depression in adulthood. British Journal of Psychiatry, 174:112-20.
34. Scher CD, Stein MB, Asmundson GJ, et al. 2001. The childhood trauma questionnaire in a community sample: psychometric properties and normative data. Journal of Traumatic Stress, 14:843-57.
35. Schmider J, Lammers CH, Gotthardt U, et al. 1995. Combined dexamethasone/ corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I. Biological Psychiatry, 38:797-802.
36. Teicher MH, Andersen SL, Polcari A, et al. 2003. The neurobiological consequences of early stress and childhood maltreatment. Neuroscience & Biobehavioral Reviews, 27:3 3-44.
37. Teicher MH, Tomoda A, Andersen SL. 2006. Neurobiological consequences of early stress and childhood maltreatment: are results from human and animal studies comparable? Ann NY Acad Sci, 1071:313-23.
38. Watson S, Gallagher P, Del-Estal D, et al. 2002. Hypothalamic-pituitary-adrenal axis function in patients with chronic depression. Psychological Medicine, 32:1021-8.
39. Watson S, Gallagher P, Ritchie JC, et al. 2004. Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder. British Journal of Psychiatry, 184:496-502.
40. Webster MJ, Knable MB, O'Grady J, et al. 2002. Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Molecular Psychiatry, 7:985-94.
41. Yehuda R, Lowy MT, Southwick SM, et al. 1991. Lymphocyte glucocorticoid receptor number in posttraumatic; stress disorder. American Journal of Psychiatry, 148:499-504.