Novel flutamide regulated genes in the rat ventral prostate: Differential modulation of their expression by castration and flutamide treatments

Asian Journal of Andrology

Volumn 9, Issue 6, 2007, Pages 801-808

  Limaye, Anil M ^a   Asangani, Irfan ^a   Bora, Namrata ^a   Kondaiah, Paturu ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Androgens; Antiandrogen; Castration; Differential display reverse transcriptase polymerase chain reaction; Flutamide; Prostate

Indexed keywords

ANDROGEN RECEPTOR; BETA 2 MICROGLOBULIN; CYTOPLASMIC FRAGILE X MENTAL RETARDATION INTERACTING PROTEIN 2; ESTRADIOL; FLUTAMIDE; GENE PRODUCT; GLYCOPROTEIN; MESSENGER RNA; PUMILIO 1; RIBOPHORIN II; SPERMINE BINDING PROTEIN; TESTOSTERONE PROPIONATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE INDUCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROSTATE VENTRAL LOBE; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANDROGEN ANTAGONISTS; ANIMALS; BETA 2-MICROGLOBULIN; FLUTAMIDE; GENE EXPRESSION REGULATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; ORCHIECTOMY; PROSTATE; RATS; RATS, WISTAR; RNA-BINDING PROTEINS;

EID: 36048934615     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1111/j.1745-7262.2007.00293.x     Document Type: Article

References (20)

1. Feldman BJ, Feldman D. The development of androgen independent prostate cancer. Nat Rev Cancer 2001; 1: 34-45.
2. Griffiths K, Eaton CL, Davies P. Prostatic cancer: Aetiology and endocrinology. Horm Res 1989; 32 Suppl 1: 38-43.
3. Lee YF, Lin WJ, Huang J, Messing EM, Chan FL, Wilding G, et al. Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells. Cancer Res 2002; 62: 6039-44.
4. Wang Y, Shao C, Shi CH, Zhang L, Yue HH, Wang PF, et al. Change of the cell cycle after flutamide treatment in prostate cancer cells and its molecular mechanism. Asian J Androl 2005; 7: 375-80.
5. Wan JS, Erlander MG. Cloning differentially expressed genes by using differential display and subtractive hybridization. Methods Mol Biol 1997; 85: 45-68.
6. Desai KV, Kondaiah P. Androgen ablation results in differential regulation of transforming growth factor-beta isoforms in rat male accessory sex organs and epididymis. J Mol Endocrinol 2000; 24: 253-60.
7. Chang CS, Saltzman AG, Hiipakka RA, Huang IY, Liao SS. Prostatic spermine-binding protein. Cloning and nucleotide sequence of cDNA, amino acid sequence, and androgenic control of mRNA level. J Biol Chem 1987; 262: 2826-31.
8. Rowley DR, Dang TD, McBride L, Gerdes MJ, Lu B, Larsen M. Beta-2 microglobulin is mitogenic to PC-3 prostatic carcinoma cells and antagonistic to transforming growth factor beta 1 action. Cancer Res 1995; 55: 781-6.
9. Kyprianou N, Isaacs JT. Expression of transforming growth factor-beta in the rat ventral prostate during castration-induced programmed cell death. Mol Endocrinol 1989; 3: 1515-22.
10. Griffin DE, Ward BJ, Jauregui E, Johnson RT, Vaisberg A. Immune activation in measles. N Engl J Med 1989; 320: 1667-72.
11. Mehta PD, Kulczycki J, Mehta SP, Sobczyk W, Coyle PK, Sersen EA, et al. Increased levels of beta 2-microglobulin, soluble interleukin-2 receptor, and soluble CD8 in patients with subacute sclerosing panencephalitis. Clin Immunol Immunopathol 1992; 65: 53-9.
12. Jiang F, Wang Z. Identification of androgen responsive genes in the rat ventral prostate by complementary deoxyribonucleic acid subtraction and microarray. Endocrinology 2003; 144: 1257-65.
13. Desai KV, Michalowska AM, Kondaiah P, Ward JM, Shih JH, Green JE. Gene expression profiling identifies a unique androgen mediated inflammatory/ immune signature and a PTEN (phosphatase and tensin homolog deleted on chromosome 10)-mediated apoptotic response specific to the rat ventral prostate. Mol Endocrinol 2004; 18: 2895-907.
14. Comery TA, Harris JB, Willems PJ, Oostra BA, Irwin SA, Weiler IJ, et al. Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits. Proc Natl Acad Sci U S A 1997; 94: 5401-4.
15. Corbin F, Bouillon M, Fortin A, Morin S, Rousseau F, Khandjian EW. The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes. Hum Mol Genet 1997; 6: 1465-72.
16. Laggerbauer B, Ostareck D, Keidel EM, Ostareck-Lederer A, Fischer U. Evidence that fragile X mental retardation protein is a negative regulator of translation. Hum Mol Genet 2001; 10: 329-38.
17. Zhang X, Colombel M, Raffo A, Buttyan R. Enhanced expression of p53 mRNA and protein in the regressing rat ventral prostate gland. Biochem Biophys Res Commun 1994; 198: 1189-94.
18. Saller E, Tom E, Brunori M, Otter M, Estreicher A, Mack DH, et al. Increased apoptosis induction by 121F mutant p53. EMBO J 1999; 18: 4424-37.
19. Spassov DS, Jurecic R. The PUF family of RNA-binding proteins: Does evolutionarily conserved structure equal conserved function? IUBMB Life 2003; 55: 359-66.
20. Sonoda J, Wharton RP. Recruitment of Nanos to hunchback mRNA by Pumilio. Genes Dev 1999; 13: 2704-12.