Diepoxybutane activates the mitochondrial apoptotic pathway and mediates apoptosis in human lymphoblasts through oxidative stress

Toxicology in Vitro

Volumn 21, Issue 8, 2007, Pages 1429-1441

  Yadavilli, Sridevi ^a   Martinez Ceballos, Eduardo ^a   Snowden Aikens, Janana ^a   Hurst, Angela ^a   Joseph, Tranole ^a   Albrecht, Thomas ^b   Muganda, Perpetua M ^a  

^a SOUTHERN UNIVERSITY   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Apoptosis; Butadiene; Diepoxybutane; Human TK6 lymphoblasts; Mitochondrial apoptotic pathway; N acetyl l cysteine; Oxidative stress; Reactive oxygen species (ROS)

Indexed keywords

ACETYLCYSTEINE; BUTADIENE DIEPOXIDE; CASPASE 3; CASPASE 9; CYTOCHROME C; PROTEIN BAK; PROTEIN BAX; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG POTENCY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOBLAST; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOLECULAR MECHANICS; OXIDATIVE STRESS; PETROCHEMICAL INDUSTRY; TOXICITY TESTING;

APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CELL LINE; CYTOCHROMES C; EPOXY COMPOUNDS; HUMANS; LYMPHOCYTES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATIVE STRESS; UP-REGULATION;

EID: 36048931431     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.06.007     Document Type: Article

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