Hippocampal volumes are larger in postmenopausal women using estrogen therapy compared to past users, never users and men: A possible window of opportunity effect

Neurobiology of Aging

Volumn 29, Issue 1, 2008, Pages 95-101

  Lord, Catherine ^a   Buss, Claudia ^b   Lupien, Sonia J ^a   Pruessner, Jens C ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF TRIER   (Germany)

Author keywords

Brain; Estrogen; Hippocampal volume; Hormone therapy; Neuroimaging; Postmenopausal women

Indexed keywords

CONJUGATED ESTROGEN; ESTRADIOL; ESTROGEN; MEDROXYPROGESTERONE ACETATE;

ADULT; AGING; ARTICLE; BRAIN REGION; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ESTROGEN THERAPY; FEMALE; HIPPOCAMPUS; HUMAN; MALE; MENOPAUSAL SYNDROME; MENOPAUSE; MENSTRUATION; NEUROIMAGING; NEUROPROTECTION; NUCLEAR MAGNETIC RESONANCE IMAGING; POSTMENOPAUSE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

AGED; BRAIN MAPPING; ESTROGEN REPLACEMENT THERAPY; FEMALE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POSTMENOPAUSE; PROSPECTIVE STUDIES; REFERENCE VALUES; SEX FACTORS;

EID: 36048929121     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2006.09.001     Document Type: Article

References (40)

1. Anstey K.J., and Maller J.J. The role of volumetric MRI in understanding mild cognitive impairment and similar classifications. Aging Ment Health 7 4 (2003) 238-250
2. Behl C. Oestrogen as a neuroprotective hormone. Nat Rev Neurosci 3 6 (2002) 433-442
3. Bhavnani B.R., Berco M., and Binkley J. Equine estrogens differentially prevent neuronal cell death induced by glutamate. J Soc Gynecol Invest 10 5 (2003) 302-308
4. Boccardi M., Ghidoni R., Govoni S., Testa C., Benussi L., Bonetti M., et al. Effects of hormone therapy on brain morphology of healthy postmenopausal women: a Voxel-based morphometry study. Menopause 13 4 (2006) 584-591
5. Coffey C.E., Lucke J.F., Saxton J.A., Ratcliff G., Unitas L.J., Billig B., et al. Sex differences in brain aging: a quantitative magnetic resonance imaging study. Arch Neurol 55 2 (1998) 169-179 [erratum appears in Arch Neurol 1998 May;55(5):627]
6. Collins D.L., Neelin P., Peters T.M., and Evans A.C. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr 18 2 (1994) 192-205
7. Cowell P.E., Turetsky B.I., Gur R.C., Grossman R.I., Shtasel D.L., and Gur R.E. Sex differences in aging of the human frontal and temporal lobes. J Neurosci 14 8 (1994) 4748-4755
8. Eberling J.L., Wu C., Haan M.N., Mungas D., Buonocore M., and Jagust W.J. Preliminary evidence that estrogen protects against age-related hippocampal atrophy. Neurobiol Aging 24 5 (2003) 725-732
9. Erickson K.I., Colcombe S.J., Elavsky S., McAuley E., Korol D.L., Scalf P.E., et al. Interactive effects of fitness and hormone treatment on brain health in postmenopausal women. Neurobiol Aging (2006)
10. Erickson K.I., Colcombe S.J., Raz N., Korol D.L., Scalf P., Webb A., et al. Selective sparing of brain tissue in postmenopausal women receiving hormone replacement therapy. Neurobiol Aging 26 8 (2005) 1205-1213
11. Espeland M.A., Rapp S.R., Shumaker S.A., Brunner R., Manson J.E., Sherwin B.B., et al. Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study. Jama 291 24 (2004) 2959-2968
12. Foster T.C. Interaction of rapid signal transduction cascades and gene expression in mediating estrogen effects on memory over the life span. Front Neuroendocrinol 26 2 (2005) 51-64
13. Gibbs R.B. Effects of estrogen on basal forebrain cholinergic neurons vary as a function of dose and duration of treatment. Brain Res 757 1 (1997) 10-16
14. Goldstein J.M., Seidman L.J., Horton N.J., Makris N., Kennedy D.N., Caviness Jr. V.S., et al. Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cereb Cortex 11 6 (2001) 490-497
15. Gould E., Tanapat P., Rydel T., and Hastings N. Regulation of hippocampal neurogenesis in adulthood. Biol Psychiatry 48 8 (2000) 715-720
16. Gur R.C., Gunning-Dixon F., Bilker W.B., and Gur R.E. Sex differences in temporo-limbic and frontal brain volumes of healthy adults. Cereb Cortex 12 9 (2002) 998-1003
17. Gur R.C., Gunning-Dixon F.M., Turetsky B.I., Bilker W.B., and Gur R.E. Brain region and sex differences in age association with brain volume: a quantitative MRI study of healthy young adults. Am J Geriatr Psychiatry 10 1 (2002) 72-80
18. Gur R.C., Turetsky B.I., Matsui M., Yan M., Bilker W., Hughett P., et al. Sex differences in brain gray and white matter in healthy young adults: correlations with cognitive performance. J Neurosci 19 10 (1999) 4065-4072
19. Kantarci K., and Jack Jr. C.R. Neuroimaging in Alzheimer disease: an evidence-based review. Neuroimaging Clin N Am 13 2 (2003) 197-209
20. Lerch J.P., Pruessner J.C., Zijdenbos A., Hampel H., Teipel S.J., and Evans A.C. Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy. Cereb Cortex 15 7 (2005) 995-1001
21. MacLennan A.H., Henderson V.W., Paine B.J., Mathias J., Ramsay E.N., Ryan P., et al. Hormone therapy, timing of initiation, and cognition in women aged older than 60 years: the REMEMBER pilot study. Menopause 13 1 (2006) 28-36
22. Marriott L., and Wenk G.L. Neurobiological consequences of long-term estrogen therapy. Curr Dir Psychol Sci 13 5 (October 2004) 173-176
23. Matthews K., Cauley J., Yaffe K., and Zmuda J.M. Estrogen replacement therapy and cognitive decline in older community women. J Am Geriatr Soc 47 5 (1999) 518-523
24. McEwen B. Estrogen actions throughout the brain. Recent Prog Horm Res 57 (2002) 357-384
25. Pruessner J.C., Baldwin M.W., Dedovic K., Renwick R., Mahani N.K., Lord C., et al. Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood. Neuroimage 28 4 (2005) 815-826
26. Pruessner J.C., Collins D.L., Pruessner M., and Evans A.C. Age and gender predict volume decline in the anterior and posterior hippocampus in early adulthood. J Neurosci 21 1 (2001) 194-200
27. Pruessner J.C., Kohler S., Crane J., Pruessner M., Lord C., Byrne A., et al. Volumetry of temporopolar, perirhinal, entorhinal and parahippocampal cortex from high-resolution MR images: considering the variability of the collateral sulcus. Cereb Cortex 12 12 (2002) 1342-1353
28. Pruessner J.C., Li L.M., Serles W., Pruessner M., Collins D.L., Kabani N., et al. Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories. Cereb Cortex 10 4 (2000) 433-442
29. Rapp P.R., Morrison J.H., and Roberts J.A. Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys. J Neurosci 23 13 (2003) 5708-5714
30. Rapp S.R., Espeland M.A., Shumaker S.A., Henderson V.W., Brunner R.L., Manson J.E., et al. Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study. A randomized controlled trial. Jama 289 20 (2003) 2663-2672
31. Raz N., Rodrigue K.M., Kennedy K.M., and Acker J.D. Hormone replacement therapy and age-related brain shrinkage: regional effects. Neuroreport 15 16 (2004) 2531-2534
32. Resnick S.M., and Maki P.M. Effects of hormone replacement therapy on cognitive and brain aging. Ann NY Acad Sci 949 (2001) 203-214
33. Shughrue P.J., and Merchenthaler I. Estrogen is more than just a "sex hormone": novel sites for estrogen action in the hippocampus and cerebral cortex. Front Neuroendocrinol 21 1 (2000) 95-101
34. Sled J.G., Zijdenbos A.P., and Evans A.C. A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging 17 1 (1998) 87-97
35. Tanapat P., Hastings N.B., and Gould E. Ovarian steroids influence cell proliferation in the dentate gyrus of the adult female rat in a dose- and time-dependent manner. J Comp Neurol 481 3 (2005) 252-265
36. Tanapat P., Hastings N.B., Reeves A.J., and Gould E. Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat. J Neurosci 19 14 (1999) 5792-5801
37. Toran-Allerand C.D. Estrogen and the brain: beyond ER-alpha and ER-beta. Exp Gerontol 39 11-12 (2004) 1579-1586
38. Xu J., Kobayashi S., Yamaguchi S., Iijima K., Okada K., and Yamashita K. Gender effects on age-related changes in brain structure. AJNR Am J Neuroradiol 21 1 (2000) 112-118
39. Yesavage J.A., Brink T.L., Rose T.L., Lum O., Huang V., Adey M., et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 17 1 (1982) 37-49
40. Zec R.F., and Trivedi M.A. The effects of estrogen replacement therapy on neuropsychological functioning in postmenopausal women with and without dementia: a critical and theoretical review. Neuropsychol Rev 12 2 (2002) 65-109