-
1
-
-
0003863495
-
-
Richey, H. G, Jr, Ed, Wiley: Chichester
-
(a) Grignard Reagents: New Developments; Richey, H. G., Jr., Ed.; Wiley: Chichester, 2000.
-
(2000)
Grignard Reagents: New Developments
-
-
-
2
-
-
0003529785
-
-
G. S. Silverman, G. S, Rakita, P. E, Eds, Dekker: New York
-
(b) Handbook of Grignard Reagents; G. S. Silverman, G. S., Rakita, P. E., Eds.; Dekker: New York, 1996.
-
(1996)
Handbook of Grignard Reagents
-
-
-
3
-
-
15444368176
-
-
Knochel, P.; Dohle, W.; Gommermann, N.; Kneisel, F. F.; Kopp, F.; Korn, T.; Sapountzis, I.; Vu, V. A. Angew. Chem., Int. Ed. 2003, 42, 4303.
-
(2003)
Angew. Chem., Int. Ed
, vol.42
, pp. 4303
-
-
Knochel, P.1
Dohle, W.2
Gommermann, N.3
Kneisel, F.F.4
Kopp, F.5
Korn, T.6
Sapountzis, I.7
Vu, V.A.8
-
5
-
-
0032554909
-
-
Satoh, T.; Takano, K.; Ota, H.; Someya, H.; Matsuda, K.; Koyama, M. Tetrahedron 1998, 54, 5557.
-
(1998)
Tetrahedron
, vol.54
, pp. 5557
-
-
Satoh, T.1
Takano, K.2
Ota, H.3
Someya, H.4
Matsuda, K.5
Koyama, M.6
-
6
-
-
31044434751
-
-
(a) Stoll, A. H.; Krasovskiy, A.; Knochel, P. Angew. Chem., Int. Ed. 2006, 45, 606.
-
(2006)
Angew. Chem., Int. Ed
, vol.45
, pp. 606
-
-
Stoll, A.H.1
Krasovskiy, A.2
Knochel, P.3
-
7
-
-
0037127088
-
-
(b) Vu, V. A.; Marek, I.; Polborn, K.; Knochel, P. Angew. Chem., Int. Ed. 2002, 41, 351.
-
(2002)
Angew. Chem., Int. Ed
, vol.41
, pp. 351
-
-
Vu, V.A.1
Marek, I.2
Polborn, K.3
Knochel, P.4
-
8
-
-
0000679160
-
-
(c) Inoue, A.; Shinokubo, H.; Oshima, K. Org. Lett. 2000, 2, 651.
-
(2000)
Org. Lett
, vol.2
, pp. 651
-
-
Inoue, A.1
Shinokubo, H.2
Oshima, K.3
-
9
-
-
0039599114
-
-
(d) Hoffmann, R. W.; Hölzer, B.; Knopff, O.; Harms, K. Angew. Chem., Int. Ed. 2000, 39, 3072.
-
(2000)
Angew. Chem., Int. Ed
, vol.39
, pp. 3072
-
-
Hoffmann, R.W.1
Hölzer, B.2
Knopff, O.3
Harms, K.4
-
11
-
-
0032733188
-
-
(f) Avolio, S.; Malan, C.; Marek, I.; Knochel, P. Synlett 1999, 1820.
-
(1999)
Synlett
, pp. 1820
-
-
Avolio, S.1
Malan, C.2
Marek, I.3
Knochel, P.4
-
12
-
-
0032554909
-
-
(g) Satoh, T.; Tokano, K.; Ota, H.; Someya, H.; Matsuda, K.; Koyama, M. Tetrahedron 1998, 54, 5557.
-
(1998)
Tetrahedron
, vol.54
, pp. 5557
-
-
Satoh, T.1
Tokano, K.2
Ota, H.3
Someya, H.4
Matsuda, K.5
Koyama, M.6
-
13
-
-
0033083578
-
-
(h) Hoffmann, R. W.; Nell, P. G. Angew. Chem., Int. Ed. 1999, 38, 338.
-
(1999)
Angew. Chem., Int. Ed
, vol.38
, pp. 338
-
-
Hoffmann, R.W.1
Nell, P.G.2
-
15
-
-
0037687811
-
-
For a summary of related functionalized organolithiums, see
-
For a summary of related functionalized organolithiums, see: Najera, C.; Yus, M. Curr. Org. Chem. 2003, 7, 867.
-
(2003)
Curr. Org. Chem
, vol.7
, pp. 867
-
-
Najera, C.1
Yus, M.2
-
16
-
-
49349138085
-
-
For a first report of Mg insertion with pendant magnesium alkoxides, see
-
For a first report of Mg insertion with pendant magnesium alkoxides, see: Cahiez, G.; Alexakis, A.; Normant, J. F. Tetrahedron Lett. 1978, 3013.
-
(1978)
Tetrahedron Lett
, pp. 3013
-
-
Cahiez, G.1
Alexakis, A.2
Normant, J.F.3
-
17
-
-
0001097020
-
-
(a) Barluenga, J.; Montserrat, J. M.; Florez, J. J. Org. Chem. 1993, 58, 5976.
-
(1993)
J. Org. Chem
, vol.58
, pp. 5976
-
-
Barluenga, J.1
Montserrat, J.M.2
Florez, J.3
-
18
-
-
35948960008
-
-
(b) Barluenga, J.; Rubiera, C.; Fernandez, J. R.; Florez, J.; Yus, M. Synthesis 1987, 819.
-
(1987)
Synthesis
, pp. 819
-
-
Barluenga, J.1
Rubiera, C.2
Fernandez, J.R.3
Florez, J.4
Yus, M.5
-
22
-
-
34247847622
-
-
(a) Dos Santos, A. A.; Princival, J. L.; Comasseto, J. V.; de Barros, S. M. G.; Brainer, Neto, J. E. Tetrahedron 2007, 63, 5167.
-
(2007)
Tetrahedron
, vol.63
, pp. 5167
-
-
Dos Santos, A.A.1
Princival, J.L.2
Comasseto, J.V.3
de Barros, S.M.G.4
-
23
-
-
19544367557
-
-
(b) Princival, J. L.; de Barros, S. M. G.; Comasseto, J. V.; Dos Santos, A. A. Tetrahedron Lett. 2005, 46, 4423.
-
(2005)
Tetrahedron Lett
, vol.46
, pp. 4423
-
-
Princival, J.L.1
de Barros, S.M.G.2
Comasseto, J.V.3
Dos Santos, A.A.4
-
24
-
-
34250724942
-
-
2 hybridized organometallics containing hydroxyl or carboxyl functionality: (a) Kopp, F.; Wunderlich, S.; Knochel, P. Chem. Commun. 2007, 2075.
-
2 hybridized organometallics containing hydroxyl or carboxyl functionality: (a) Kopp, F.; Wunderlich, S.; Knochel, P. Chem. Commun. 2007, 2075.
-
-
-
-
25
-
-
33745685968
-
-
(b) Uchiyama, M.; Furuyama, T.; Kobayashi, M.; Matsumoto, Y.; Tanaka, K. J. Am. Chem. Soc. 2006, 128, 8404.
-
(2006)
J. Am. Chem. Soc
, vol.128
, pp. 8404
-
-
Uchiyama, M.1
Furuyama, T.2
Kobayashi, M.3
Matsumoto, Y.4
Tanaka, K.5
-
27
-
-
0037037947
-
-
(d) Kato, S.; Nonoyama, N.; Tomimoto, K.; Mase, T. Tetrahedron Lett. 2002, 43, 7315.
-
(2002)
Tetrahedron Lett
, vol.43
, pp. 7315
-
-
Kato, S.1
Nonoyama, N.2
Tomimoto, K.3
Mase, T.4
-
29
-
-
35948985221
-
-
Phenyllithium and MeLi are unable to promote the reaction whereas EtLi and t-BuLi were significantly inferior to the use of BuLi. Employing 2 equiv of ethylhexyllithium, trimethylsilylmethyllithium, or hexyllithium or 1 equiv and an additional equivalent of BuLi and alkylating with cyclohexanone as a test electrophile affords 4a in 34-50% yield.
-
Phenyllithium and MeLi are unable to promote the reaction whereas EtLi and t-BuLi were significantly inferior to the use of BuLi. Employing 2 equiv of ethylhexyllithium, trimethylsilylmethyllithium, or hexyllithium or 1 equiv and an additional equivalent of BuLi and alkylating with cyclohexanone as a test electrophile affords 4a in 34-50% yield.
-
-
-
-
30
-
-
35948978976
-
-
Sequential deprotonation and protonation of 1, 5b, and 5c at -78°C leads to diminishing recovery with 1-iodo-2,2,4-trimethylpentan-3- ol affording only 2-isopropyl-3,3-dimethyloxetane.
-
Sequential deprotonation and protonation of 1, 5b, and 5c at -78°C leads to diminishing recovery with 1-iodo-2,2,4-trimethylpentan-3- ol affording only 2-isopropyl-3,3-dimethyloxetane.
-
-
-
-
32
-
-
0000717185
-
-
Swiss, K. A.; Liotta, D. C.; Maryanoff, C. A. J. Am. Chem. Soc. 1990, 112, 9393.
-
(1990)
J. Am. Chem. Soc
, vol.112
, pp. 9393
-
-
Swiss, K.A.1
Liotta, D.C.2
Maryanoff, C.A.3
-
33
-
-
29344432351
-
-
Krasovskiy, A.; Straub, B. F.; Knochel, P. Angew. Chem., Int. Ed. 2006, 45, 159.
-
(2006)
Angew. Chem., Int. Ed
, vol.45
, pp. 159
-
-
Krasovskiy, A.1
Straub, B.F.2
Knochel, P.3
-
35
-
-
33845469694
-
-
(b) Eis, M. J.; Wrobel, J. E.; Ganem, B. J. Am. Chem. Soc. 1984, 106, 3693.
-
(1984)
J. Am. Chem. Soc
, vol.106
, pp. 3693
-
-
Eis, M.J.1
Wrobel, J.E.2
Ganem, B.3
|