High phenotypic diversity in infecting but not in colonizing Staphylococcus aureus populations

Environmental Microbiology

Volumn 9, Issue 12, 2007, Pages 3134-3142

  Goerke, Christiane ^a   Gressinger, Matthias ^a   Endler, Kathrin ^a   Breitkopf, Claudia ^b   Wardecki, Katrin ^b   Stern, Martin ^a   Wolz, Christiane ^a   Kahl, Barbara C ^b  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BACTERIUM IDENTIFICATION; CHILD; CLASSIFICATION; CYSTIC FIBROSIS; FEMALE; GENETICS; HEMOLYSIS; HETEROZYGOTE; HUMAN; INFANT; MALE; METABOLISM; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; NOSE; OROPHARYNX; PATHOGENICITY; PHENOTYPE; PRESCHOOL CHILD; PULSED FIELD GEL ELECTROPHORESIS; SPUTUM; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION;

ADOLESCENT; ADULT; BACTERIAL TYPING TECHNIQUES; CARRIER STATE; CHILD; CHILD, PRESCHOOL; CYSTIC FIBROSIS; ELECTROPHORESIS, GEL, PULSED-FIELD; FEMALE; HEMOLYSIS; HUMANS; INFANT; MALE; MICROBIAL SENSITIVITY TESTS; NOSE; OROPHARYNX; PHENOTYPE; SPUTUM; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 35948997389     PISSN: 14622912     EISSN: 14622920     Source Type: Journal    
DOI: 10.1111/j.1462-2920.2007.01423.x     Document Type: Article

References (32)

1. Boles, B.R., Thoendel, M. Singh, P.K. (2004) Self-generated diversity produces 'insurance effects' in biofilm communities. Proc Natl Acad Sci USA 101 : 16630 16635.
2. Brakstad, O.G., Aasbakk, K. Maeland, J.A. (1992) Detection of Staphylococcus aureus by polymerase chain reaction amplification of the nuc gene. J Clin Microbiol 30 : 1654 1660.
3. Branger, C., Gardye, C. Lambert Zechovsky, N. (1996) Persistence of Staphylococcus aureus strains among cystic fibrosis patients over extended periods of time. J Med Microbiol 45 : 294 301.
4. Brito, N., Falcon, M.A., Carnicero, A., Gutierrez-Navarro, A.M. Mansito, T.B. (1989) Purification and peptidase activity of a bacteriolytic extracellular enzyme from Pseudomonas aeruginosa. Res Microbiol 140 : 125 137.
5. Brockhurst, M.A., Buckling, A. Rainey, P.B. (2005) The effect of a bacteriophage on diversification of the opportunistic bacterial pathogen, Pseudomonas aeruginosa. Proc Biol Sci 272 : 1385 1391.
6. Cespedes, C., Said-Salim, B., Miller, M., Lo, S.H., Kreiswirth, B.N., Gordon, R.J., et al. (2005) The clonality of Staphylococcus aureus nasal carriage. J Infect Dis 191 : 444 452.
7. Chantratita, N., Wuthiekanun, V., Boonbumrung, K., Tiyawisutsri, R., Vesaratchavest, M., Limmathurotsakul, D., et al. (2007) Biological relevance of colony morphology and phenotypic switching by Burkholderia pseudomallei. J Bacteriol 189 : 807 817.
8. CSLI (2005) Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard. Wayne, PA, USA : Clinical and Laboratory Standards Institute.
9. Galdbart, J.O., Morvan, A., Desplaces, N. el Sohl, N. (1999) Phenotypic and genomic variation among Staphylococcus epidermidis strains infecting joint prostheses. J Clin Microbiol 37 : 1306 1312.
10. Goerke, C., Kraning, K., Stern, M., Döring, G., Botzenhart, K. Wolz, C. (2000) Molecular epidemiology of community-acquired Staphylococcus aureus in families with and without cystic fibrosis patients. J Infect Dis 181 : 984 989.
11. Goerke, C., Matias y Papenberg, S., Dasbach, S., Dietz, K., Ziebach, R., Kahl, B.C. Wolz, C. (2004) Increased frequency of genomic alterations in Staphylococcus aureus during chronic infection is in part due to phage mobilization. J Infect Dis 189 : 724 734.
12. Goerke, C., Wirtz, C., Fluckiger, U. Wolz, C. (2006) Extensive phage dynamics in Staphylococcus aureus contributes to adaptation to the human host during infection. Mol Microbiol 61 : 1673 1685.
13. Gomez, M.I., Lee, A., Reddy, B., Muir, A., Soong, G., Pitt, A., et al. (2004) Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1. Nat Med 10 : 842 848.
14. Harmsen, D., Claus, H., Witte, W., Rothganger, J., Claus, H., Turnwald, D. Vogel, U. (2003) Typing of methicillin-resistant Staphylococcus aureus in a University hospital setting by using novel software for spa repeat determination and database management. J Clin Microbiol 41 : 5442 5448.
15. Kahl, B.C., Herrmann, M., Everding, A.S., Koch, H.G., Becker, K., Harms, E., et al. (1998) Persistent infection with small colony variant strains of Staphylococcus aureus in patients with cystic fibrosis. J Infect Dis 177 : 1023 1029.
16. Kahl, B.C., Duebbers, A., Lubritz, G., Haeberle, J., Koch, H.G., Ritzerfeld, B., et al. (2003) Population dynamics of persistent Staphylococcus aureus isolated from the airways of cystic fibrosis patients during a 6-year prospective study. J Clin Microbiol 41 : 4424 4427.
17. Kahl, B.C., Mellmann, A., Deiwick, S., Peters, G. Harmsen, D. (2005) Variation of the polymorphic region X of the protein A gene during persistent airway infection of cystic fibrosis patients reflects two independent mechanisms of genetic change in Staphylococcus aureus. J Clin Microbiol 43 : 502 505.
18. Kang, J. Blaser, M.J. (2006) Bacterial populations as perfect gases: genomic integrity and diversification tensions in Helicobacter pylori. Nat Rev Microbiol 4 : 826 836.
19. Kluytmans, J.A., van Belkum, A. Verbrugh, H. (1997) Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev 10 : 505 520.
20. Lomholt, H., Andersen, K.E. Kilian, M. (2005) Staphylococcus aureus clonal dynamics and virulence factors in children with atopic dermatitis. J Invest Dermatol 125 : 977 982.
21. Mansito, T.B., Falcon, M.A., Moreno, J., Carnicero, A. Gutierrez-Navarro, A.M. (1987) Effects of staphylolytic enzymes from Pseudomonas aeruginosa on the growth and ultrastructure of Staphylococcus aureus. Microbios 49 : 55 64.
22. Moore, P.C.L. Lindsay, J.A. (2001) Genetic Variation among hospital isolates of methicillin-sensitive Staphylococcus aureus: evidence for horizontal transfer of virulence genes. J Clin Microbiol 39 : 2760 2767.
23. Mwangi, M.M., Wu, S.W., Zhou, Y., de Sieradzki, K.L.H., Richardson, P., et al. (2007) Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing. Proc Natl Acad Sci USA 104 : 9451 9456.
24. O'Neill, A.J. Chopra, I. (2002) Insertional inactivation of mutS in Staphylococcus aureus reveals potential for elevated mutation frequencies, although the prevalence of mutators in clinical isolates is low. J Antimicrob Chemother 50 : 161 169.
25. Oliver, A., Canton, R., Campo, P., Baquero, F. Blazquez, J. (2000) High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science 288 : 1251 1254.
26. Proctor, R.A., von Eiff, C., Kahl, B.C., Becker, K., McNamara, P., Herrmann, M. Peters, G. (2006) Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections. Nat Rev Microbiol 4 : 295 305.
27. Prunier, A.L., Malbruny, B., Laurans, M., Brouard, J., Duhamel, J.F. Leclercq, R. (2003) High rate of macrolide resistance in Staphylococcus aureus strains from patients with cystic fibrosis reveals high proportions of hypermutable strains. J Infect Dis 187 : 1709 1716.
28. Qazi, S., Middleton, B., Muharram, S.H., Cockayne, A., Hill, P., O'Shea, P., et al. (2006) N-acylhomoserine lactones antagonize virulence gene expression and quorum sensing in Staphylococcus aureus. Infect Immun 74 : 910 919.
29. Saba, S., Soong, G., Greenberg, S. Prince, A. (2002) Bacterial stimulation of epithelial G-CSF and GM-CSF expression promotes PMN survival in CF airways. Am J Respir Cell Mol Biol 27 : 561 567.
30. Smith, E.E., Buckley, D.G., Wu, Z., Saenphimmachak, C., Hoffman, L.R., D'Argenio, D.A., et al. (2006) Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci USA 103 : 8487 8492.
31. Voggu, L., Schlag, S., Biswas, R., Rosenstein, R., Rausch, C. Gotz, F. (2006) Microevolution of cytochrome bd oxidase in Staphylococci and its implication in resistance to respiratory toxins released by Pseudomonas. J Bacteriol 188 : 8079 8086.
32. Yachi, S. Loreau, M. (1999) Biodiversity and ecosystem productivity in a fluctuating environment: The insurance hypothesis. Proc Natl Acad Sci USA 96 : 1463 1468.