Concanavalin A protects mice from a lethal inoculation of intragastric Klebsiella pneumoniae and reduces the induced liver damage

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 9, 2007, Pages 3122-3130

  Kuo, Chih Feng ^a   Wang, Ya Hui ^b   Lei, Huan Yao ^b   Wang, Chiou Huey ^c   Tsao, Nina ^a  

^a I SHOU UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c E DA HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CONCANAVALIN A;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BACTERIAL COUNT; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; ENTEROBACTER INFECTION; HEPATITIS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; LETHALITY; LIVER INJURY; LIVER NECROSIS; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BACTEREMIA; CONCANAVALIN A; IMMUNOHISTOCHEMISTRY; IMMUNOLOGIC FACTORS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; LIVER; MACROPHAGES; MICE; MICE, INBRED C57BL;

EID: 35948977261     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01379-06     Document Type: Article

References (37)

1. Arakawa, Y., M. Ohta, R. Wacharotayankun, M. Mori, N. Kido, H. Ito, T. Komatsu, T. Sugiyama, and N. Kato. 1991. Biosynthesis of Klebsiella K2 capsular polysaccharide in Escherichia coli HB101 requires the functions of rmpA and the chromosomal cps gene cluster of the virulent strain Klebsiella pneumoniae Chedid (O1:K2). Infect. Immun. 59:2043-2050.
2. Arakawa, Y., R. Wacharotayankun, T. Nagatsuka, H. Ito, N. Kato, and M. Ohta. 1995. Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid. J. Bacteriol. 177:1788-1796.
3. Cahill, M., B. Chang, and A. Murray. 2000. Bilateral endogenous bacterial endophthalmitis associated with pyogenic hepatic abscess. Br. J. Ophthalmol. 84:1436.
4. Chang, S. C., C. T. Fang, P. R. Hsueh, Y. C. Chen, and K. T. Luh. 2000. Klebsiella pneumoniae isolates causing fiver abscess in Taiwan. Diagn. Microbiol. Infect. Dis. 37:279-284.
5. Chiu, C. H., L. H. Su, T. L. Wu, and I. J. Hung. 2001. Liver abscess caused by Klebsiella pneumoniae in siblings. J. Clin. Microbiol. 39:2351-2353.
6. Chou, H. C., C. Z. Lee, L. C. Ma, C. T. Fang, S. C. Chang, and J. T. Wang. 2004. Isolation of a chromosomal region of Klebsiella pneumoniae associated with allantoin metabolism and liver infection. Infect. Immun. 72:3783-3792.
7. Chuang, Y. P., C. T. Fang, S. Y. Lai, S. C. Chang, and J. T. Wang. 2006. Genetic determinants of capsular serotype K1 of Klebsiella pneumoniae causing primary pyogenic liver abscess. J. Infect. Dis. 193:645-654.
8. Cortes, G., B. de Astorza, V. J. Benedi, and S. Alberti. 2002. Role of the htrA gene in Klebsiella pneumoniae virulence. Infect. Immun. 70:4772-4776.
9. Czuprynski, C. J., J. F. Brown, N. Maroushek, R. D. Wagner, and H. Steinberg. 1994. Administration of anti-granulocyte mAb RB6-8C5 impairs the resistance of mice to Listeria monocytogenes infection. J. Immunol. 152:1836-1846.
10. DiSabato, G., J. M. Hall, and L. Thompson. 1987. T cell mitogens and polyclonal B cell activators. Methods Enzymol. 150:3-17.
11. Fang, C. T., Y. C. Chen, S. C. Chang, W. Y. Shau, and K. T. Luh. 2000. Klebsiella pneumoniae meningitis: timing of antimicrobial therapy and prognosis. QJM 93:45-53.
12. Fang, C. T., Y. P. Chuang, C. T. Shun, S. C. Chang, and J. T. Wang. 2004. A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J. Exp. Med. 199:697-705.
13. Felipe, I., S. Bim, and C. C. Somensi. 1995. Increased clearance of Candida albicans from the peritoneal cavity of mice pre-treated with concanavalin-A or jacalin. Braz. J. Med. Biol. Res. 28:477-483.
14. Fung, C. P., F. Y. Chang, S. C. Lee, B. S. Hu, B. T. Kuo, C. Y. Liu, and L. K. Siu. 2002. A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis? Gut 50:420-424.
15. Gantner, F., M. Leist, A. W. Lohse, P. G. Germann, and G. Tiegs. 1995. Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology 21:190-198.
16. Gregory, S. H., and E. J. Wing. 2002. Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacteria! infections. J. Leukoc. Biol. 72:239-248.
17. Huang, L. R., H. L. Wu, P. J. Chen, and D. S. Chen. 2006. An immunocompetent mouse model for the tolerance of human chronic hepatitis B virus infection. Proc. Natl. Acad. Sci. USA 103:17862-17867.
18. Kaposzta, R., P. Tree, L. Maródi, and S. Gordon. 1998. Characteristics of invasive candidiasis in gamma interferon and interleukin-4-deficient mice: role of macrophages in host defense against Candida albicans. Infect. Immun. 66:1708-1717.
19. Ko, W. C., D. L. Paterson, A. J. Sagnimeni, D. S. Hansen, A. Von Gottberg, S. Mohapatra, J. M. Casellas, H. Goossens, L. Mulazimoglu, G. Trenholme, K. P. Kingman. J. G. McCormack, and V. L. Yu. 2002. Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns. Emerg. Infect. Dis. 8:160-166.
20. Lai, Y. C., S. L. Yang, H. L. Peng, and H. Y. Chang. 2000. Identification of genes present specifically in a virulent strain of Klebsiella pneumoniae. Infect. Immun. 68:7149-7151.
21. Lau, Y. J., B. S. Hu, W. L. Wu, Y. H. Lin, H. Y. Chang, and Z. Y. Shi. 2000. Identification of a major cluster of Klebsiella pneumoniae isolates from patients with liver abscess in Taiwan. J. Clin. Microbiol. 38:412-414.
22. Lederman, E. R., and N. F. Crum. 2005. Pyrogenic liver abscess with a focus on Klebsiella pneumoniae as a primary pathogen: an emerging disease with unique clinical characteristics. Am. J. Gastroenterol. 100:322-331.
23. Leist, M., and A. Wendel. 1996. A novel mechanism of murine hepatocyte death inducible by concanavalin A. J. Hepatol. 25:948-959.
24. Marchetti, M., B. Arico, D. Burroni, N. Figura, R. Rappuoli, and P. Ghiara. 1995. Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science 267:1655-1658.
25. Merino, S., M. Altarriba, L. Izquierdo, M. M. Nogueras, M. Regue, and J. M. Tomas. 2000. Cloning and sequencing of the Klebsiella pneumoniae O5 wb gene cluster and its role in pathogenesis. Infect. Immun. 68:2435-2440.
26. Miyagi, T., T. Takehara, T. Tatsumi, T. Suzuki, M. Jinushi, Y. Kanazawa, N. Hiramatsu, T. Kanto, S. Tsuji, M. Hori, and N. Hayashi. 2004. Concanavalin A injection activates intrahepatic innate immune cells to provoke an antitumor effect in murine liver. Hepatology 40:1190-1196.
27. Moresco, T. R., L. C. J. Gaziri, Y. Yasumoto, and I. Felipe. 2002. Phagocytic and candidacidal activities of macrophages from suckling and adult mice pretreated with concanavalin-A. Med. Mycol. 40:393-397.
28. Ofek, I., and N. Sharon. 1988. Lectinophagocytosis: a molecular mechanism of recognition between cell surface sugars and lectins in the phagocytosis of bacteria. Infect. Immun. 56:539-547.
29. Ohmori, S., K. Shiraki, K. Ito, H. Inoue, T. Ito, T. Sakai, K. Takase, and T. Nakano. 2002. Septic endophthalmitis and meningitis associated with Klebsiella pneumoniae liver abscess. Hepatol. Res. 22:307-312.
30. Podschun, R., and U. Ullmann. 1998. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin. Microbiol. Rev. 11:589-603.
31. + subset expression in murine candidiasis: Th responses correlate directly with genetically determined susceptibility or vaccine-induced resistance. J. Immunol. 150:925-931.
32. Sawyer, R. T., R. E. Garner, and J. A. Hudson. 1992. Effect of lectins on hepatic clearance and killing of Candida albicans by the isolated perfused mouse liver. Infect. Immun. 60:1041-1046.
33. Shultz, L. D., P. A. Schweitzer, S. W. Christiansen. B. Gott, I. B. Schweitzer, B. Tennent, S. McKenna, L. Mobraaten, T. V. Rajan, D. L. Greiner, and E. H. Leiter. 1995. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J. Immunol. 154:180-191.
34. Takuya, A., M. Suzuki, H. Matsui, T. Tomoyasu, H. Sashinami, A. Nakane, and T. Yamamoto. 2003. Lon, a stress-induced ATP-dependent protease, is critically important for systemic Salmonella enterica serovar Typhimurium infection of mice. Infect. Immun. 71:690-696.
35. Tiegs, G., J. Hentschel, and A. Wendel. 1992. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Investig. 90:196-203.
36. Wang, J. H., Y. C. Liu, S. S. Lee, M. Y. Yen, Y. S. Chen, J. H. Wang, S. R. Wann, and H. H. Lin. 1998. Primary liver abscess due to Klebsiella pneumoniae in Taiwan. Clin. Infect. Dis. 26:1434-1438.
37. Xu, X., H. Wei, Z. Dong, Y. Chen, and Z. Tian. 2006. The differential effects of low dose and high dose concanavalin A on cytokine profile and their importance in liver injury. Inflamm. Res. 55:144-152.