Association between p53 expression and Bcl-2, P-glycoprotein, topoisomerase II alpha, thymidylate synthase and thymidine phosphorylase as potential therapeutic targets in colorectal cancer patients

Pakistan Journal of Biological Sciences

Volumn 10, Issue 19, 2007, Pages 3350-3355

  Arbabi Bidgoli, Sepideh ^a   Azizi, Ebrahim ^b   Zavarhei, Mansour Djamali ^c  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Bcl 2; Colorectal adenocarcinoma; P glycoprotein; p53; Therapeutics targets; Thymidine phosphorylase; Thymidylate synthase; Topoisomerase II alpha

Indexed keywords

EID: 35948968307     PISSN: 10288880     EISSN: 18125735     Source Type: Journal    
DOI: 10.3923/pjbs.2007.3350.3355     Document Type: Article

References (17)

1. Allegra, C.J., S. Paik, L.H. Colangelo, A.L. Parr, I. Kirsch and G. Kim et al., 2003. Prognostic value of thymidylate synthase, Ki-67 and p53 in patients with Duke's B and C colon cancer. J. Clin. Oncol., 21: 241-250.
2. Anwar, S., I.M. Frayling, N.A. Scott and G.L. Carlson, 2004. Systematic review of genetic influences on the prognosis of colorectal cancer. Br. J. Surg., 91: 1275-1291.
3. Arbabi Bidgoli, S., B. Minaee, M.H. Ghahremani, M. Djamali Zavarei, S. Fouladdel and E. Azizi, 2005. Correlation between Thymidine Phosphoruylase (TP) expression and sex of patients in colorectal carcinoma. IJCR., 1: 47-52.
4. Aschele, C., D. Debernardis, G. Tunesi, F. Maley and A. Sobrero, 2000. Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relation with the clinical response to 5FU. Clin. Cancer Res., 6: 4797-4802.
5. Buglioni, S., I. D'Agnano, M. Cosimelli, S. Vasselli, C. D'Angelo and M. Tedesco et al., 1999. Evaluation of multiple bio-pathological factors in colorectal adenocarcinomas: Independent prognostic role of p53 and bcl-2. Int. J. Cancer, 84: 545-552.
6. Catalano, V., A.M. Bladelike, P. Giordani and S. Cascinu, 2001. Molecular markers predictive of response to chemotherapy in gastrointestinal tumors. Crit. Rev. Oncol. Hematol., 38: 93-104.
7. Hollstein, M., D. Sidransky, B. Vogelstein and C.C. Harris, 1991. P53 mutations in human cancers. Science, 253: 49-53.
8. Jessup, J.M., 1998. Tumor markers-prognostic and therapeutic implications for colorectal carcinoma. Surg. Oncol., 7: 139-151.
9. Jin, W., M.Q. Gao, Z.W. Lin and D.X. Yang, 2004. Multiple biomarkers of colorectal tumor in a differential diagnosis model: A quantitative study. World J. Gastroenterol., 10: 439-342.
10. Manne, U., R.B. Myers, C. Morson, R.B. Poczatek, S. Dillard and H. Weiss et al., 1997. Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma. Int. J. Cancer, 74: 346-358.
11. Matsumoto, Y., H. Takano, S. Nagao and T. Fojo, 2001. Altered topoisomerase II o and multidrug resistance-associated protein levels during drug selection: Adaptations to increasing drug pressure. Jpn. J. Cancer Res., 92: 968-974.
12. Nagy, B., L. Tiszlavicz, J. Eller, J. Molnar and L. Thurzo, 1994. p53 status and the efficacy of cancer therapy in vivo. Science, 266: 807-810.
13. Pomp, J., J. Davelaar, J. Blom, C. van Krimpen, A. Zwinderman and W. Quint et al., 1994. Radiotherapy for oesophagus carcinoma: The impact of p53 on treatment outcome. Radiother. Oncol., 46: 179-184.
14. Rubin, E. and J.L. Farber, 1998. Pathology. Philadelphia: JB Lippincott.
15. Saleh, H.A., H. Jackson and M. Banerjee, 2000. Immunohistochemical expression of Bcl-2 and p53 oncoproteins: Correlation with Ki67 proliferation index and prognostic histopathologic parameters in colorectal neoplasia. Applied Immunohistochem Mol. Morphol., 8: 175-182.
16. Soong, R., B. Powell, H. Elsaleh, G. Gnanasampanthan, D.R. Smith and H.S. Goh et al., 2000. Prognostic significance of TP53 gene mutation in 995 cases of colorectal carcinoma: Influence of tumour site, stage, adjuvant chemotherapy and type of mutation. Eur. J. Cancer, 36: 2053-2060.
17. Woolson, R.F. and W.R. Clarke, 2002. Statistical Methods for the Analysis of Biomedical Data. 2nd Edn., Wiley Interscience.