Interlobular bile duct loss in pediatric cholestatic disease is associated with aberrant cytokeratin 7 expression by hepatocytes

Pediatric and Developmental Pathology

Volumn 10, Issue 5, 2007, Pages 383-390

  Ernst, Linda M ^a   Spinner, Nancy B ^a   Piccoli, David A ^a   Mauger, Joanne ^a   Russo, Pierre ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alagille syndrome; Bile duct paucity; Cytokeratin 7; Extrahepatic biliary atresia

Indexed keywords

CD56 ANTIGEN; CYTOKERATIN 7; PARAFFIN; PROTEIN; PROTEIN OV6; UNCLASSIFIED DRUG;

ALAGILLE SYNDROME; ARTICLE; BILE ACID SYNTHESIS; BILE DUCT; BILE DUCT ATRESIA; CONTROLLED STUDY; EXPLANT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INBORN ERROR OF BILE ACID SYNTHESIS; INBORN ERROR OF METABOLISM; INFANT; INTRAHEPATIC CHOLESTASIS; LIVER BIOPSY; LIVER CELL; METAPLASIA; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SCLEROSING CHOLANGITIS; SCORING SYSTEM; STAINING; STEM CELL;

ADOLESCENT; ANTIGENS, CD56; ANTIGENS, DIFFERENTIATION; BILE DUCTS; CHILD; CHILD, PRESCHOOL; CHOLESTASIS; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; KERATIN-7;

EID: 35948963318     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/06-09-0171.1     Document Type: Article

References (20)

1. Spagnoli FM, Amicone L, Tripodi M, Weiss MC. Identification of a bipotential precursor cell in hepatic cell lines derived from transgenic mice expressing cyto-Met in the liver. J Cell Biol 1998;143(4):1101-1112.
2. van Eyken P, Sciot R, van Damme B, de Wolf-Peeters C, Desmet VJ. Keratin immunohistochemistry in normal human liver: cytokeratin pattern of hepatocytes, bile ducts and acinar gradient. Virchows Arch A Pathol Anat Histopathol 1987;412(1):63-72.
3. Van Eyken P, Sciot R, Callea F, Van der Steen K, Moerman P, Desmet VJ. The development of the intrahepatic bile ducts in man: a keratin- immunohistochemical study. Hepatology 1988;8(6):1586-1595.
4. Libbrecht L, Roskams T. Hepatic progenitor cells in human liver diseases. Semin Cell Dev Biol 2002;13(6):389-396.
5. Torbenson M, Wang J, Abraham S, Maitra A, Boitnott J. Bile ducts and ductules are positive for CD56 (N-CAM) in most cases of extrahepatic biliary atresia. Am J Surg Pathol 2003;27(11):1454-1457.
6. Libbrecht L, Cassiman D, Desmet V, Roskams T. Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases. Histochem Cell Biol 2001;116(3):233-239.
7. Crosby HA, Hubscher SG, Joplin RE, Kelly DA, Strain AJ. Irnmunolocalization of OV-6, a putative progenitor cell marker in human fetal and diseased pediatric liver. Hepatology 1998;28(4):980-985.
8. Roskams T, van den Oord JJ, De Vos R, Desmet VJ. Neuroendocrine features of reactive bile ductules in cholestatic liver disease. Am J Pathol 1990;137(5):1019-1025.
9. Saxena R, Theise N. Canals of Hering: recent insights and current knowledge. Semin Liver Dis 2004;24(1):43-48.
10. Van Eyken P, Sciot R, Desmet VJ. A cytokeratin immunohistochemical study of alcoholic liver disease: evidence that hepatocytes can express "bile duct-type" cytokeratins. Histopathology 1988;13(6):605-617.
11. Van Eyken P, Sciot R, Desmet VJ. A cytokeratin immunohistochemical study of cholestatic liver disease: evidence that hepatocytes can express "bile duct-type" cytokeratins. Histopathology 1989;15(2):125-135.
12. Treem WR, Krzymowski GA, Cartun RW, Pedersen CA, Hyams JS, Berman M. Cytokeratin irnmunohistochemical examination of liver biopsies in infants with Alagille syndrome and biliary atresia. J Pediatr Gastroenterol Nutr 1992;15(1):73-80.
13. Yabushita K, Yamamoto K, Ibuki N, et al. Aberrant expression of cytokeratin 7 as a histological marker of progression in primary biliary cirrhosis. Liver 2001;21(1):50-55.
14. Goldstein NS, Soman A, Gordon SC. Portal tract eosinophils and hepatocyte cytokeratin 7 immunoreactivity helps distinguish early-stage, mildly active primary biliary cirrhosis and autoimmune hepatitis. Am J Clin Pathol 2001;116(6):846-853.
15. Uenishi T, Kubo S, Hirohashi K, et al. Expression of bile duct-type cytokeratin in noncancerous hepatocytes in patients with hepatitis B virus-related hepatocellular carcinoma. Hepatogastroenterology 2003;50(52):1101-1104.
16. Ren C, Paronetto F, Mak KM, Leo MA, Lieber CS. Cytokeratin 7 staining of hepatocytes predicts progression to more severe fibrosis in alcohol-fed baboons. J Hepatol 2003;38(6):770-775.
17. Nietgen GW, Vacanti JP, Perez-Atayde AR. Intrahepatic bile duct loss in biliary atresia despite portoenterostomy: a consequence of ongoing obstruction? Gastroenterology 1992;102(6):2126-2133.
18. Michalopoulos GK, Barua L, Bowen WC. Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology 2005;41(3):535-544.
19. Blaheta RA, Kronenberger B, Woitaschek D, et al. Dedifferentiation of human hepatocytes by extracellular matrix proteins in vitro: quantitative and qualitative investigation of cytokeratin 7, 8, 18, 19 and vimentin filaments. J Hepatol 1998;28(4):677-690.
20. Nakatani K, Seki S, Kawada N, Kobayashi K, Kaneda K. Expression of neural cell adhesion molecule (N-CAM) in perisinusoidal stellate cells of the human liver. Cell Tissue Res 1996;283(1):159-165.