Apolipoprotein E gene polymorphism in nonalcoholic fatty liver disease

Digestive Diseases and Sciences

Volumn 52, Issue 12, 2007, Pages 3399-3403

  Demirag, Mehmet Derya ^a,b   Onen, Hacer Ilke ^a   Karaoguz, Meral Yirmibes ^a   Dogan, Ibrahim ^a   Karakan, Tarkan ^a   Ekmekci, Abdullah ^a   Guz, Galip ^a  

^a GAZI UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY FACULTY OF MEDICINE   (Turkey)

Author keywords

Apolipoprotein; Fatty liver; Gene; Gene polymorphism; Liver; Liver steatosis

Indexed keywords

ALANINE AMINOTRANSFERASE; APOLIPOPROTEIN E; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; LIPID; LIPOPROTEIN; LIVER ENZYME; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY MASS; CONTROLLED STUDY; DIGESTION; DISEASE MARKER; DNA POLYMORPHISM; ECHOGRAPHY; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GENE AMPLIFICATION; GENE FREQUENCY; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION MAPPING; STATISTICAL SIGNIFICANCE; TRIACYLGLYCEROL BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; ALLELES; APOLIPOPROTEINS E; BODY MASS INDEX; DNA; FATTY LIVER; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROGNOSIS;

EID: 35948933416     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-9740-5     Document Type: Article

References (28)

1. Utermann G, Hees M, Steinmetz A (1977) Polymorphism of apolipoprotein E and occurance of dysbetalipoproteinemi in men. Nature 269:604-607
2. Zannis VI, Breslow JL, Utermann G, Mahley RW, Weisgraber KH, Havel RJ, Goldstein JL, Brown MS, Schonfeld G, Hazzard WR, Blum C (1982) Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J Lipid Res 23:9112-914
3. Schaefer EJ, Cupples LA, Wilson PW, Levy D, Osgood D, Parpos S, Pedro-Botet J, Daly JA, Ordovas JM (2001) Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis 154:529-537
4. Eto M, Saito M, Nakata H, Iwashima Y, Watanabe K, Ikoda A, Kaku K (2002) Type III hyperlipoproteinema with apolipoprotein E2/2 genotype in Japan. Clin Genet 61:416-422
5. de Knijff P, Kaptein A, Boomsma D, Princen HM, Frants RR, Havekes LM (1991) Apolipoprotein E polymorphism affects plasma levels of lipoprotein(a). Atherosclerosis 90:169-174
6. Kao JT, Tsai KS, Chang CJ, Huang PC (1995) The effects of apolipoprotein E polymorphism on the distribution of lipids and lipoproteins in the Chinese population. Atherosclerosis 114:55-59
7. Dallongeville J, Lussier-Cacan S, Davignon J (1992) Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis. J Lipid Res 33:447-454
8. Caldwell SH, Oelsner DH, Iezzoni JC, et al. (1999) Cryptogenic cirrhosis clinical characterization and risk factors for underlying disease. Hepatology 29:664-669
9. Bahcecioglu IH, Koruk M, YIlmaz O, Bolukbas C, Bolukbas F, Tuncer I, Ataseven H, Yalcin K, Ozercan IH (2006) Demographic and clinicopathological characteristics of nonalcoholic fatty liver disease in the East-Southeastern Anatolia regions in Turkey. Med Princ Pract 15:62-68
10. Ludwig J, Viggiano TR, McGill DB, Oh BJ (1980) Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 55:434-438
11. Wanless IR, Lentz JS (1990) Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 12:1106-1110
12. Sharabi Y, Eldad A (2000) Nonalcoholic fatty liver disease is associated with hyperlipidemia and obesity. Am J Med 109:171
13. Becker U, Deis A, Sorensen TI, Gronbaek M, Borch-Johnsen K, Muller CF, Schnohr P, Jensen G (1996) Prediction of risk of liver disease by alcohol intake, sex, and age: a prospective population study. Hepatology 23:1025-1029.
14. Foster KJ, Dewbury KC, Griffith AH, Wright R (1980) The accuracy of ultrasound in the detection of fatty infiltration of the liver. Br J Radiol 53:440-442
15. Dissing J, Rudbeck L, Marcher H (1996) A five minute procedure for extraction of genomic DNA from whole blood, semen, and forensic stains for PCR. Adv Forens Haemogenet 6:269-271
16. Wenham PR, Price WH, Blundell G (1991) Apolipoprotein E genotyping by one stage PCR. Lancet 337:1158-1159
17. Davignon J, Gregg RE, Sing CF (1988) Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 8:1-21
18. Lee DM, Lee SO, Mun BS, Ahn HS, Park HY, Lee HS, Kim DG (2002) Relation of apolipoprotein E polymorphism to clinically diagnosed fatty liver disease. Korean J Hepatol 8:355-362
19. Yang MH, Son HJ, Sung JD, Choi YH, Koh KC, Yoo BC, Paik SW (2005) The relationship between apolipoprotein E polymorphism, lipoprotein (a) and fatty liver disease. Hepatogastroenterology 52:1832-1835
20. Demant T, Bedford D, Packard CJ, Shepherd J (1991) Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects. J Clin Invest 88:1490-1501
21. Riches FM, Watts GF, Van Bockxmeer FM, Hua J, Song S, Humphries SE, Talmud PJ (1998) Apolipoprotein B signal peptide and apolipoprotein E genotypes as determinants of the hepatic secretion of VLDL apoB in obese men. J Lipid Res 39:1752-1758
22. Welty FK, Lichtenstein AH, Barrett PH, Jenner JL, Dolnikowski GG, Schaefer EJ (2000) Effects of ApoE genotype on ApoB-48 and ApoB-100 kinetics with stable isotopes in humans. Arterioscler Thromb Vasc Biol 20:1807-1810
23. Kuipers F, Jong MC, Lin Y, Eck M, Havinga R, Bloks V, Verkade HJ, Hofker MH, Moshage H, Berkel TJ, Vonk RJ, Havekes LM (1997) Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes. J Clin Invest 100:2915-2922
24. Mensenkamp AR, Jong MC, van Goor H, van Luyn MJ, Bloks V, Havinga R, Voshol PJ, Hofker MH, van Dijk KW, Havekes LM, Kuipers F (1999) Apolipoprotein E participates in the regulation of very low density lipoproteintriglyceride secretion by the liver. J Biol Chem 274:35711-35718
25. Mahley RW, Palaoglu KE, Atak Z, Dawson-Pepin J, Langlois AM, Cheung V, Onat H, Fulks P, Mahley LL, Vakar F (1995) Turkish Heart Study. Lipids, lipoproteins, and apolipoproteins. J Lipid Res 36:839-859
26. Yang ZJ, Zhu TB, Ma GS, Yin H, Qian WC, Zhang FM, Cao KJ, Ma WZ (2001) Apolipoprotein E polymorphism in the early onset coronary heart disease. Chin Med J 114:983-985
27. Muros M, Rodriguez-Ferrer C (1996) Apolipoprotein E polymorphism influence on lipids, apolipoproteins and Lp(a) in a Spanish population underexpressing apo E4. Atherosclerosis 121:13-21
28. Kolovou GD, Daskalova DC, Hatzivassiliou M, Yiannakoruis N, Platis ND, Elisaf M, Mikhailidis DP, Cariolou MA, Cokkinos DV (2003) The epsilon 2 and 4 alleles of apolipoprotein E and ischemic vascular event in the Greek population-implications for the interpretation of similar studies. Angiology 54:51-58