Role of ascorbic acid in scavenging free radicals and lead toxicity from biosystems

Molecular Biotechnology

Volumn 37, Issue 1, 2007, Pages 62-65

  Tariq, Shabbir A ^a  

^a NONE   (Australia)

Author keywords

Antioxidants; Ascorbic acid; Biosystem; Free radicals; Lead detoxification; Metallo enzymes; Oxidative damage; Vitamin C

Indexed keywords

FREE RADICALS; LEAD; OXIDATIVE STRESS; TOXICITY; VITAMINS;

ANTIOXIDANTS; ASCORBIC ACIDS; BIOSYSTEMS; DETOXIFYING AGENTS; LEAD DETOXIFICATION; LEAD TOXICITY; METALLO ENZYMES; VITAMIN C;

ORGANIC ACIDS;

ANTIOXIDANT; ASCORBIC ACID; CHELATING AGENT; LEAD; SCAVENGER;

CHILD; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; LEAD POISONING; MEDICAL RESEARCH; OXIDATIVE STRESS; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION; ARTICLE; CHEMISTRY; FEMALE; HAIR; MALE;

ASCORBIC ACID; CHILD; FEMALE; FREE RADICAL SCAVENGERS; HAIR; HUMANS; LEAD; MALE;

EID: 35848966757     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12033-007-0045-x     Document Type: Conference Paper

References (32)

1. Schindler, T. H., Nitzsche, E. U., Munzel, T., Olschewski, M., Brink, I., Jeserich, M., Mix, M., Buser, P. T., Pfisterer, M., Solzbach, U., & Just, H. (2003). Coronary vasoregulation in patients with various risk factors in response to cold pressor testing: Contrasting myocardial blood flow responses to short- and long-term vitamin C administration. Journal of the American College of Cardiology, 42(5), 814-822.
2. Chade, A. R., Rodriguez-Porcel, M., Herrmann, J., Krier, J. D., Zhu, X., Lerman, A., & Lerman, L. O. (2003). Beneficial effects of antioxidant vitamins on the stenotic kidney. Hypertension, 42(4), 605-612.
3. Behrendt, D., Beltrame, J., Hikiti, H., Wainstein, M., Kinlay, S., Selwyn, A. P., Ganz, P., & Fang, J. C. (2006). Impact of coronary endothelial function on the progression of cardiac transplant-associated arteriosclerosis: Effect of anti-oxidant vitamins C and E. The Journal of Heart and Lung Transplantation, 25(4), 426-433.
4. Antoniades, C., Tousoulis, D., Tentolouris, C., Toutouza, M., Marinou, K., Goumas, G., Tsioufis, C., Toutouzas, P., & Stefanadis, C. (2003). Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers. Thrombosis and Haemostasis, 89(6), 990-995.
5. Neri, S., Signorelli, S. S., Torrisi, B., Pulvirenti, D., Mauceri, B., Abate, G., Ignaccolo, L., Bordonaro, F., Cilio, D., Calvagno, S., & Leotta, C. (2005). Effects of antioxidant supplementation on postprandial oxidative stress and endothelial dysfunction: A single-blind, 15-day clinical trial in patients with untreated type 2 diabetes, subjects with impaired glucose tolerance, and healthy controls. Clinical Therapeutics, 7(11), 1764-1773.
6. Chade, A. R., Krier, J. D., Rodriguez-Porcel, M., Breen, J. F., McKusick, M. A., Lerman, A., & Lerman, L. O. (2004). Comparison of acute and chronic antioxidant interventions in experimental renovascular disease. American Journal of Physiology. Renal Physiology, 286(6), F1079-1086.
7. Richartz, B. M., Werner, G. S., Ferrari, M., & Figulla, H. R. (2001). Reversibility of coronary endothelial vasomotor dysfunction in idiopathic dilated cardiomyopathy: acute effects of vitamin C. The American Journal of Cardiology, 88(9), 1001-1005.
8. Sato, M., Matsumoto, Y., Morita, H., Takemura, H., Shimoi, K., & Amano, I. (2003). Effects of vitamin supplementation on microcirculatory disturbance in hemodialysis patients without peripheral arterial disease. Clinical Nephrology, 60(1), 28-34.
9. Ellis, G. R., Anderson, R. A., Chirkov, Y. Y., Morris-Thurgood, J., Jackson, S. K., Lewis, M. J., Horowitz, J. D., & Frenneaux, M. P. (2001). Acute effects of vitamin C on platelet responsiveness to nitric oxide donors and endothelial function in patients with chronic heart failure. Journal of Cardiovascular Pharmacology, 37(5), 564-570.
10. Takase, B., Etsuda, H., Matsushima, Y., Ayaori, M., Kusano, H., Hamabe, A., Uehata, A., Ohsuzu, F., Ishihara, M., & Kurita, A. (2004). Effect of chronic oral supplementation with vitamins on the endothelial function in chronic smokers. Angiology, 55(6), 653-660.
11. Versari, D., Herrmann, J., Gossl, M., Mannheim, D., Sattler, K., Meyer, F. B., Lerman, L. O., & Lerman, A. (2006). Chronic antioxidant supplementation impairs coronary endothelial function and myocardial perfusion in normal pigs. Hypertension, 47(3), 475-481.
12. Rodriguez-Porcel, M., Herrman, J., Chade, A. R., Krier, J. D., Breen, J. F., Lerman, A., & Lerman, L. O. (2004). Long-term antioxidant intervention improves myocardial microvascular function in experimental hypertension. Hypertension, 43(2), 493-498.
13. Zhu, X. Y., Rodriguez-Porcel, M., Bentley, M. D., Chade, A. R., Sica, V., Napoli, C., Caplice, N., Ritman, E. L., Lerman, A., & Lerman, L. O. (2004). Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia. Circulation, 109(17), 2109-2115.
14. Ulker, S., McMaster, D., McKeown, P. P., & Bayraktutan, U. (2004). Antioxidant vitamins C and E ameliorate hyperglycaemia-induced oxidative stress in coronary endothelial cells. Diabetes, Obesity & Metabolism, 6(6), 442-451.
15. Stulak, J. M., Lerman, A., Porcel, M. R., Caccitolo, J. A., Romero, J. C., Schaff, H. V., Napoli, C., & Lerman, L. O. (2001). Renal vascular function in hypercholesterolemia is preserved by chronic antioxidant supplementation. Journal of the American Society of Nephrology, 12(9), 1882-1891.
16. Kinlay, S., Behrendt, D., Fang, J. C., Delagrange, D., Morrow, J., Witztum, J. L, Rifai, N., Selwyn, A. P., Creager, M. A., & Ganz, P. (2004). Long-term effect of combined vitamins E and C on coronary and peripheral endothelial function. Journal of the American College of Cardiology, 43(4), 629-634.
17. Tam, L. S., Li, E. K., Leung, V. Y., Griffith, J. F., Benzie, I. F., Lim, P. L., Whitney, B., Lee, V. W., Lee, K. K., Thomas, G. N., & Tomlinson, B. (2005). Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: A double blind, placebo controlled pilot study. The Journal of Rheumatology, 32(2), 275-282.
18. McKechnie, R., Rubenfire, M., & Mosca, L. (2002). Antioxidant nutrient supplementation and brachial reactivity in patients with coronary artery disease. The Journal of Laboratory and Clinical Medicine, 139(3), 133-139.
19. Raitakari, O. T., Adams, M. R., McCredie, R. J., Griffiths, K. A., Stocker, R., & Celermajer, D. S. (2000). Oral vitamin C and endothelial function in smokers: Short-term improvement, but no sustained beneficial effect. Journal of the American College of Cardiology, 35(6), 1616-1621.
20. Alper, G., Olukman, M., Irer, S., Caglayan, O., Duman, E., Yilmaz, C., & Ulker, S. (2006). Effect of vitamin E and C supplementation combined with oral antidiabetic therapy on the endothelial dysfunction in the neonatally streptozotocin injected diabetic rat. Diabetes/Metabolism Research and Reviews, 22(3), 190-197.
21. Cathcart, R. F. (1981). The method of determining proper doses of vitamin C for the treatment of diseases by titrating to bowel tolerance. Journal of Orthomolecular Psychiatry, 10, 125-133.
22. Rahbar, M.H., White, F., Agboatwalla, M., Hozhabri, S., & Luby, S. (2002). Factors associated with elevated blood lead concentrations in children in Karachi, Pakistan. Bulletin of the World Health Organization, 80(10), 769-775.
23. Hozharbi, S. (2002). Lead-based paint is a hazard to young children: Implications for Pakistani children. Journal of the Pakistan Medical Association, 52(5), 224-226.
24. Khan, A. H., Khan, A., Ghani, F., & Khurshid, M. (2001). Low-level lead exposure and blood lead levels in children: A cross-sectional survey. Archives of Environmental Health, 56(6), 501-505.
25. Rahman, A., & Yousuf, F.A. (2002). Lead levels in primary teeth of children in Karachi. Annals of Tropical Paediatrics, 22(1), 79-83.
26. White, F., Rahbar, M. H., Agboatwalla, M., Luby, S., Iqbal A., & Hozhabri, S. (2001). Elevated blood lead levels in Karachi children. Bulletin of the World Health Organization, 79(2), 173.
27. Tarion, R. (1999). The effect of vitamin C supplementation on lead levels in children. B.Sc. (Honours) Thesis, Universiti Malaysia Sabah, Malaysia.
28. Ahmad, Z. (2001). The effect of vitamin C supplementation on lead levels in Ranau and Papar school children. B.Sc. (Honours) Thesis, Universiti Malaysia Sabah, Malaysia.
29. Gilani, A. H., Tariq, S. A., Shah, A. J.,. Zaidi, S. A. H., Butt, Z. A., & Ghayur, M. N. (2003). Effect of vitamin C supplementation on body lead in children. Proceedings of the Summer Meeting The British Pharmacological Society, University of Surrey, June, 11/24.
30. Joel, A., Simon, J. A., & Esther, S. (1999). Relationship of ascorbic acid to blood lead levels. The Journal of the American Medical Association, 281, 2289-2293.
31. Houston, D. K., & Johnson, M. A. (2000). Does vitamin C intake protect against lead toxicity? Nutrition Reviews, 58(3 Pt 1), 73-75.
32. Tandon, S. K., Chatterjee, M., Bhargava, A., Shukla, V., & Bihari, V. (2001). Lead poisoning in Indian silver refiners. The Science of the Total Environment, 281(1-3), 177-182.