Randomized, double-blind, placebo-controlled trial of cephalexin for treatment of uncomplicated skin abscesses in a population at risk for community-acquired methicillin-resistant Staphylococcus aureus infection

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 11, 2007, Pages 4044-4048

  Rajendran, Priya M ^a   Young, David ^a,c   Maurer, Toby ^a   Chambers, Henry ^a   Perdreau Remington, Francoise ^a   Ro, Peter ^b   Harris, Hobart ^a  

^a Department of Dermatology ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM ANTIBIOTIC; CEFALEXIN; PLACEBO;

ABSCESS DRAINAGE; ABSENCE OF SIDE EFFECTS; ADULT; AGED; ARTICLE; BACTERIUM CULTURE; BACTERIUM ISOLATION; CLINICAL TRIAL; COMMUNITY; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; OUTCOME ASSESSMENT; OUTPATIENT; POPULATION RESEARCH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETROSPECTIVE STUDY; SKIN ABSCESS; SOFT TISSUE INFECTION; STAPHYLOCOCCUS INFECTION; TREATMENT DURATION; TREATMENT RESPONSE;

ABSCESS; ADULT; AGED; ANTI-BACTERIAL AGENTS; CEPHALEXIN; COMMUNITY-ACQUIRED INFECTIONS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCAL SKIN INFECTIONS; STAPHYLOCOCCUS AUREUS; TREATMENT OUTCOME;

EID: 35848959525     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00377-07     Document Type: Article

References (30)

1. Breedt, J., J. Teras, J. Gardovskis, F. J. Maritz, T. Vaasna, D. P. Ross, M. Gioud-Paquet, N. Dartois, E. J. Ellis-Grosse, and E. Loh. 2005. Safety and efficacy of tigecycline in treatment of skin and skin structure infections: results of a double-blind phase 3 comparison study with vancomycin-aztreonam. Antimicrob. Agents Chemother. 49:4658-4666.
2. Brook, I. 2002. Microbiology of polymicrobial abscesses and implications for therapy. J. Antimicrob. Chemother. 50:805-810.
3. Carleton, H. A., B. A. Diep, E. D. Charlebois, G. F. Sensabaugh, and F. Perdreau-Remington. 2004. Community-adapted methicillin-resistant Staphylococcus aureus (MRSA): population dynamics of an expanding community reservoir of MRSA. J. Infect. Dis. 190:1730-1738.
4. Diep, B. A., S. R. Gill, R. F. Chang, T. H. Phan, J. H. Chen, M. G. Davidson, F. Lin, J. Lin, H. A. Carleton, E. F. Mongodin, G. F. Sensabaugh, and F. Perdreau-Remington. 2006. Complete genome sequence of USA300, an epidemic clone of community-acquired methicillin-resistant Staphylococcus aureus. Lancet 367:731-739.
5. Diep, B. A., G. F. Sensabaugh, N. S. Somboona, H. A. Carleton, and F. Perdreau-Remington. 2004. Widespread skin and soft-tissue infections due to two methicillin-resistant Staphylococcus aureus strains harboring the genes for Panton-Valentine leucocidin. J. Clin. Microbiol. 42:2080-2084.
6. Division of Anti-Infective Drug Product, Food and Drug Administration. 1992. Points to consider, 1992. Division of Anti-Infective Drug Product, Food and Drug Administration, Washington, DC.
7. Eady, E. A., and J. H. Cove. 2003. Staphylococcal resistance revisited: community-acquired methicillin resistant Staphylococcus aureus - an emerging problem for the management of skin and soft tissue infections. Curr. Opin. Infect. Dis. 16:103-124.
8. Ebright, J. R., and B. Pieper. 2002. Skin and soft tissue infections in injection drug users. Infect. Dis. Clin. N. Am. 16:697-712.
9. File, T. M., Jr. 1999. Overview of resistance in the 1990s. Chest 115:3S-8S.
10. Frazee, B. W., J. Lynn, E. D. Charlebois, L. Lambert, D. Lowery, and F. Perdreau-Remington. 2005. High prevalence of methicillin-resistant Staphylococcus aureus in emergency department skin and soft tissue infections. Ann. Emerg. Med. 45:311-320.
11. Fridkin, S. K., J. C. Hageman, M. Morrison, L. T. Sanza, K. Como-Sabetti, J. A. Jernigan, K. Harriman, L. H. Harrison, R. Lynfield, and M. M. Farley. 2005. Methicillin-resistant Staphylococcus aureus disease in three communities. N. Engl. J. Med. 352:1436-1444.
12. Harris, H. W., and D. M. Young. 2002. Care of injection drug users with soft tissue infections in San Francisco, California. Arch. Surg. 137:1217-1222.
13. Jauregui, L. E., S. Babazadeh, E. Seltzer, L. Goldberg, D. Krievins, M. Frederick, D. Krause, I. Satilovs, Z. Endzinas, J. Breaux, and W. O'Riordan. 2005. Randomized, double-blind comparison of once-weekly dalbavancin versus twice-daily linezolid therapy for the treatment of complicated skin and skin structure infections. Clin. Infect. Dis. 41:1407-1415.
14. Lee, M. C., A. M. Rios, M. F. Aten, A. Mejias, D. Cavuoti, G. H. McCracken, Jr., and R. D. Hardy. 2004. Management and outcome of children with skin and soft tissue abscesses caused by community-acquired methicillin-resistant Staphylococcus aureus. Pediatr. Infect. Dis. J. 23:123-127.
15. Lieberman, J. M. 2003. Appropriate antibiotic use and why it is important: the challenges of bacterial resistance. Pediatr. Infect. Dis. J. 22:1143-1151.
16. Lina, G., Y. Piemont, F. Godail-Gamot, M. Bes, M. O. Peter, V. Gauduchon, F. Vandenesch, and J. Etienne. 1999. Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin. Infect. Dis. 29:1128-1132.
17. Llera, J. L., and R. C. Levy. 1985. Treatment of cutaneous abscess: a double-blind clinical study. Ann. Emerg. Med. 14:15-19.
18. Mah, M. W., and Z. A. Memish. 2000. Antibiotic resistance. An impending crisis. Saudi Med. J. 21:1125-1129.
19. Miller, L. G., F. Perdreau-Remington, G. Rieg, S. Mehdi, J. Perlroth, A. S. Bayer, A. W. Tang, T. O. Phung, and B. Spellberg. 2005. Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N. Engl. J. Med. 352:1445-1453.
20. Moran, G. J., A. Krishnadasan, R. J. Gorwitz, G. E. Fosheim, L. K. McDougal, R. B. Carey, and D. A. Talan. 2006. Methicillin-resistant S. aureus infections among patients in the emergency department. N. Engl. J. Med. 355:666-674.
21. Naimi, T. S., K. H. LeDell, K. Como-Sabetti, S. M. Borchardt, D. J. Boxrud, J. Etienne, S. K. Johnson, F. Vandenesch, S. Fridkin, C. O'Boyle, R. N. Danila, and R. Lynfield. 2003. Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA 290:2976-2984.
22. NCCLS. 1994. NCCLS 2000 methods for dilution antimicrobial susceptibility test for bacteria that grow aerobically. Approved standard, 5th ed. Document M7-A5. NCCLS, Wayne, PA.
23. Pan, E. S., B. A. Diep, H. A. Carleton, E. D. Charlebois, G. F. Sensabaugh, B. L. Haller, and F. Perdreau-Remington. 2003. Increasing prevalence of methicillin-resistant Staphylococcus aureus infection in California jails. Clin. Infect. Dis. 37:1384-1388.
24. Rajendran, P. M., D. M. Young, T. Maurer, H. F. Chambers, M. A. Jacobson, and H. W. Harris. 2007. Antibiotic use in the treatment of soft tissue abscesses: a survey of current practice. Surg. Infect. 8:237-238.
25. Rybak, M. J. 2004. Resistance to antimicrobial agents: an update. Pharmacotherapy 24:203S-215S.
26. Salgado, C. D., B. M. Fair, and D. P. Calfee. 2003. Community-acquired methicillin-resistant Staphylococcus aureus: a meta-analysis of prevalence and risk factors. Clin. Infect. Dis. 36:131-139.
27. Stryjewski, M. E., W. D. O'Riordan, W. K. Lau, F. D. Pien, L. M. Dunbar, M. Vallee, V. G. Fowler, Jr., V. H. Chu, E. Spencer, S. L. Barriere, M. M. Kitt, C. H. Cabell, and G. R. Corey. 2005. Telavancin versus standard therapy for treatment of complicated skin and soft-tissue infections due to gram-positive bacteria. Clin. Infect. Dis. 40:1601-1607.
28. Waldrop, R. D., C. Prejean, and R. Singleton. 1998. Overuse of parenteral antibiotics for wound care in an urban emergency department. Am. J. Emerg. Med. 16:343-345.
29. Weigelt, J., K. Itani, D. Stevens, W. Lau, M. Dryden, and C. Knirsch. 2005. Linezolid versus vancomycin in treatment of complicated skin and soft tissue infections. Antimicrob. Agents Chemother. 49:2260-2266.
30. Young, D. M., H. W. Harris, E. D. Charlebois, H. Chambers, A. Campbell, F. Perdreau-Remington, C. Lee, M. Mankani, R. Mackersie, and W. P. Schecter. 2004. An epidemic of methicillin-resistant Staphylococcus aureus soft tissue infections among medically underserved patients. Arch. Surg. 139:947-951.