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Volumn 25, Issue 12, 2007, Pages 2454-2462

Olmesartan and pravastatin additively reduce development of atherosclerosis in APOE*3Leiden transgenic mice

Author keywords

APOE*3Leiden mice; Atherosclerosis; Combination therapy; Olmesartan; Pravastatin

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; OLMESARTAN; PRAVASTATIN; TRIACYLGLYCEROL;

EID: 35848957040     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e3282ef79f7     Document Type: Article
Times cited : (28)

References (48)
  • 1
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature 2002; 420:868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 2
    • 2342438770 scopus 로고    scopus 로고
    • Cholesterol management and the reduction of cardiovascular risk
    • Nixon JV. Cholesterol management and the reduction of cardiovascular risk. Prev Cardiol 2004; 7:34-39.
    • (2004) Prev Cardiol , vol.7 , pp. 34-39
    • Nixon, J.V.1
  • 3
    • 0029050796 scopus 로고
    • Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderately elevated serum cholesterol levels. The Regression Growth Evaluation Statin Study (REGRESS)
    • Jukema JW, Bruschke AV, van Boven AJ, Reiber JH, Bal ET, Zwinderman AH, et al. Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderately elevated serum cholesterol levels. The Regression Growth Evaluation Statin Study (REGRESS). Circulation 1995; 91:2528-2540.
    • (1995) Circulation , vol.91 , pp. 2528-2540
    • Jukema, J.W.1    Bruschke, A.V.2    van Boven, A.J.3    Reiber, J.H.4    Bal, E.T.5    Zwinderman, A.H.6
  • 4
    • 0027981582 scopus 로고
    • Effect of simvastatin on coronary atheroma: The Multicentre Anti-Atheroma Study (MAAS)
    • Effect of simvastatin on coronary atheroma: the Multicentre Anti-Atheroma Study (MAAS). Lancet 1994; 344:633-638.
    • (1994) Lancet , vol.344 , pp. 633-638
  • 5
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators
    • Sacks FM, Pfeffer MA, Moye LA, Rouleau JL, Rutherford JD, Cole TG, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med 1996; 335:1001-1009.
    • (1996) N Engl J Med , vol.335 , pp. 1001-1009
    • Sacks, F.M.1    Pfeffer, M.A.2    Moye, L.A.3    Rouleau, J.L.4    Rutherford, J.D.5    Cole, T.G.6
  • 6
    • 0030590742 scopus 로고    scopus 로고
    • West of Scotland Coronary Prevention Study: identification of high-risk groups and comparison with other cardiovascular intervention trials. Lancet 1996; 348:1339-1342.
    • West of Scotland Coronary Prevention Study: identification of high-risk groups and comparison with other cardiovascular intervention trials. Lancet 1996; 348:1339-1342.
  • 7
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. N Engl J Med 1998; 339:1349-1357
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. N Engl J Med 1998; 339:1349-1357.
  • 8
    • 0036118915 scopus 로고    scopus 로고
    • Pleiotropic effects of HMG-CoA reductase inhibitors
    • Werner N, Nickenig G, Laufs U. Pleiotropic effects of HMG-CoA reductase inhibitors. Basic Res Cardiol 2002; 97:105-116.
    • (2002) Basic Res Cardiol , vol.97 , pp. 105-116
    • Werner, N.1    Nickenig, G.2    Laufs, U.3
  • 9
    • 0141430989 scopus 로고    scopus 로고
    • Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: Evidence for antiinflammatory effects of rosuvastatin
    • Kleemann R, Princen HM, Emeis JJ, Jukema JW, Fontijn RD, Horrevoets AJ, et al. Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin. Circulation 2003; 108:1368-1374.
    • (2003) Circulation , vol.108 , pp. 1368-1374
    • Kleemann, R.1    Princen, H.M.2    Emeis, J.J.3    Jukema, J.W.4    Fontijn, R.D.5    Horrevoets, A.J.6
  • 11
    • 0030770395 scopus 로고    scopus 로고
    • Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells
    • Marumo T, Schini-Kerth VB, Fisslthaler B, Busse R. Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells. Circulation 1997; 96:2361-2367.
    • (1997) Circulation , vol.96 , pp. 2361-2367
    • Marumo, T.1    Schini-Kerth, V.B.2    Fisslthaler, B.3    Busse, R.4
  • 12
    • 0033777328 scopus 로고    scopus 로고
    • Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-kappaB (NF-kappaB) transcription factor
    • Brasier AR, Jamaluddin M, Han Y, Patterson C, Runge MS. Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-kappaB (NF-kappaB) transcription factor. Mol Cell Biochem 2000; 212 (1-2):155-169.
    • (2000) Mol Cell Biochem , vol.212 , Issue.1-2 , pp. 155-169
    • Brasier, A.R.1    Jamaluddin, M.2    Han, Y.3    Patterson, C.4    Runge, M.S.5
  • 14
    • 13144267689 scopus 로고    scopus 로고
    • Beyond blood pressure: Endothelial protection against hypercholesterolemia by angiotensin II type-1 receptor blockade
    • Morawietz H. Beyond blood pressure: endothelial protection against hypercholesterolemia by angiotensin II type-1 receptor blockade. Hypertension 2005; 45:185-186.
    • (2005) Hypertension , vol.45 , pp. 185-186
    • Morawietz, H.1
  • 15
    • 11144328072 scopus 로고    scopus 로고
    • Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor
    • Daugherty A, Rateri DL, Lu H, Inagami T, Cassis LA. Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation 2004; 110:3849-3857.
    • (2004) Circulation , vol.110 , pp. 3849-3857
    • Daugherty, A.1    Rateri, D.L.2    Lu, H.3    Inagami, T.4    Cassis, L.A.5
  • 16
    • 0034525602 scopus 로고    scopus 로고
    • Regulation of the angiotensin AT1 receptor by hypercholesterolaemia
    • Nickenig G, Wassmann S, Bohm M. Regulation of the angiotensin AT1 receptor by hypercholesterolaemia. Diabetes Obes Metab 2000; 2:223-228.
    • (2000) Diabetes Obes Metab , vol.2 , pp. 223-228
    • Nickenig, G.1    Wassmann, S.2    Bohm, M.3
  • 17
    • 0026786643 scopus 로고
    • Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators
    • Pfeffer MA, Braunwald E, Moye LA, Basta L, Brown EJ Jr, Cuddy TE, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N Engl J Med 1992; 327:669-677.
    • (1992) N Engl J Med , vol.327 , pp. 669-677
    • Pfeffer, M.A.1    Braunwald, E.2    Moye, L.A.3    Basta, L.4    Brown Jr, E.J.5    Cuddy, T.E.6
  • 18
    • 0025285390 scopus 로고
    • Studies of left ventricular dysfunction (SOLVD)-rationale, design and methods: Two trials that evaluate the effect of enalapril in patients with reduced ejection fraction
    • Studies of left ventricular dysfunction (SOLVD)-rationale, design and methods: two trials that evaluate the effect of enalapril in patients with reduced ejection fraction. Am J Cardiol 1990; 66:315-322.
    • (1990) Am J Cardiol , vol.66 , pp. 315-322
  • 19
    • 0030902115 scopus 로고    scopus 로고
    • Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE)
    • Pitt B, Segal R, Martinez FA, Meurers G, Cowley AJ, Thomas I, et al. Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE). Lancet 1997; 349:747-752.
    • (1997) Lancet , vol.349 , pp. 747-752
    • Pitt, B.1    Segal, R.2    Martinez, F.A.3    Meurers, G.4    Cowley, A.J.5    Thomas, I.6
  • 20
    • 2342512836 scopus 로고    scopus 로고
    • Olmesartan compared with other angiotensin II receptor antagonists: Head-to-head trials
    • Stumpe KO. Olmesartan compared with other angiotensin II receptor antagonists: head-to-head trials. Clin Ther 2004; 26 (Suppl A):A33-A37.
    • (2004) Clin Ther , vol.26 , Issue.SUPPL. A
    • Stumpe, K.O.1
  • 21
    • 4844231461 scopus 로고    scopus 로고
    • Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation
    • Fliser D, Buchholz K, Haller H. Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation. Circulation 2004; 110:1103-1107.
    • (2004) Circulation , vol.110 , pp. 1103-1107
    • Fliser, D.1    Buchholz, K.2    Haller, H.3
  • 22
    • 0035799373 scopus 로고    scopus 로고
    • Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice
    • Delsing DJ, Offerman EH, van Duyvenvoorde W, van der BH, de Wit EC, Gijbels MJ, et al. Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice. Circulation 2001; 103:1778-1786.
    • (2001) Circulation , vol.103 , pp. 1778-1786
    • Delsing, D.J.1    Offerman, E.H.2    van Duyvenvoorde, W.3    van der, B.H.4    de Wit, E.C.5    Gijbels, M.J.6
  • 23
    • 0028215636 scopus 로고    scopus 로고
    • van Vlijmen BJ, van den Maagdenberg AM, Gijbels MJ, van der BH, HogenEsch H, Frants RR, et al. Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice. J Clin Invest 1994; 93:1403-1410.
    • van Vlijmen BJ, van den Maagdenberg AM, Gijbels MJ, van der BH, HogenEsch H, Frants RR, et al. Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice. J Clin Invest 1994; 93:1403-1410.
  • 24
    • 0031445149 scopus 로고    scopus 로고
    • Attenuation of plasma low density lipoprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in mice devoid of low density lipoprotein receptors
    • Bisgaier CL, Essenburg AD, Auerbach BJ, Pape ME, Sekerke CS, Gee A, et al. Attenuation of plasma low density lipoprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in mice devoid of low density lipoprotein receptors. J Lipid Res 1997; 38:2502-2515.
    • (1997) J Lipid Res , vol.38 , pp. 2502-2515
    • Bisgaier, C.L.1    Essenburg, A.D.2    Auerbach, B.J.3    Pape, M.E.4    Sekerke, C.S.5    Gee, A.6
  • 28
    • 11144233335 scopus 로고    scopus 로고
    • Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice
    • Verschuren L, Kleemann R, Offerman EH, Szalai AJ, Emeis SJ, Princen HM, Kooistra T. Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice. Arterioscler Thromb Vasc Biol 2005; 25:161-167.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 161-167
    • Verschuren, L.1    Kleemann, R.2    Offerman, E.H.3    Szalai, A.J.4    Emeis, S.J.5    Princen, H.M.6    Kooistra, T.7
  • 29
    • 23244435918 scopus 로고    scopus 로고
    • No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-leiden/human C-reactive protein transgenic mice
    • Trion A, de Maat MP, Jukema JW, Van Der LA, Maas MC, Offerman EH, et al. No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-leiden/human C-reactive protein transgenic mice. Arterioscler Thromb Vasc Biol 2005; 25:1635-1640.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1635-1640
    • Trion, A.1    de Maat, M.P.2    Jukema, J.W.3    Van Der, L.A.4    Maas, M.C.5    Offerman, E.H.6
  • 30
    • 33644939620 scopus 로고    scopus 로고
    • Meta-analysis of large outcome trials of angiotensin receptor blockers in hypertension
    • Cheung BM, Cheung GT, Lauder IJ, Lau CP, Kumana CR. Meta-analysis of large outcome trials of angiotensin receptor blockers in hypertension. J Hum Hypertens 2006; 20:37-43.
    • (2006) J Hum Hypertens , vol.20 , pp. 37-43
    • Cheung, B.M.1    Cheung, G.T.2    Lauder, I.J.3    Lau, C.P.4    Kumana, C.R.5
  • 31
    • 3042570661 scopus 로고    scopus 로고
    • Statins in hypercholesterolaemia: A dose-specific meta-analysis of lipid changes in randomised, double blind trials
    • Edwards JE, Moore RA. Statins in hypercholesterolaemia: a dose-specific meta-analysis of lipid changes in randomised, double blind trials. BMC Fam Pract 2003; 4:18.
    • (2003) BMC Fam Pract , vol.4 , pp. 18
    • Edwards, J.E.1    Moore, R.A.2
  • 32
    • 0035912134 scopus 로고    scopus 로고
    • New pharmacologic aspects of CS-866, the newest angiotensin II receptor antagonist
    • 8A:33C-36C
    • Koike H. New pharmacologic aspects of CS-866, the newest angiotensin II receptor antagonist. Am J Cardiol 2001; 87 (8A):33C-36C.
    • (2001) Am J Cardiol , pp. 87
    • Koike, H.1
  • 33
    • 21644472752 scopus 로고    scopus 로고
    • Effect of combination of calcium antagonist, azelnidipine, and AT1 receptor blocker, olmesartan, on atherosclerosis in apolipoprotein E-deficient mice
    • Suzuki J, Iwai M, Li Z, Li JM, Min LJ, Ide A, et al. Effect of combination of calcium antagonist, azelnidipine, and AT1 receptor blocker, olmesartan, on atherosclerosis in apolipoprotein E-deficient mice. J Hypertens 2005; 23:1383-1389.
    • (2005) J Hypertens , vol.23 , pp. 1383-1389
    • Suzuki, J.1    Iwai, M.2    Li, Z.3    Li, J.M.4    Min, L.J.5    Ide, A.6
  • 34
    • 0034704893 scopus 로고    scopus 로고
    • C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    • Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000; 342:836-843.
    • (2000) N Engl J Med , vol.342 , pp. 836-843
    • Ridker, P.M.1    Hennekens, C.H.2    Buring, J.E.3    Rifai, N.4
  • 35
    • 0029838433 scopus 로고    scopus 로고
    • Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: A meta-analysis of population-based prospective studies
    • Hokanson JE, Austin MA. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk 1996; 3:213-219.
    • (1996) J Cardiovasc Risk , vol.3 , pp. 213-219
    • Hokanson, J.E.1    Austin, M.A.2
  • 36
    • 2342644068 scopus 로고    scopus 로고
    • Olmesartan medoxomil, an angiotensin II receptor blocker ameliorates insulin resistance and decreases triglyceride production in fructose-fed rats
    • Okada K, Hirano T, Ran J, Adachi M. Olmesartan medoxomil, an angiotensin II receptor blocker ameliorates insulin resistance and decreases triglyceride production in fructose-fed rats. Hypertens Res 2004; 27:293-299.
    • (2004) Hypertens Res , vol.27 , pp. 293-299
    • Okada, K.1    Hirano, T.2    Ran, J.3    Adachi, M.4
  • 37
    • 18744383954 scopus 로고    scopus 로고
    • Treating the metabolic syndrome: Telmisartan as a peroxisome proliferator-activated receptor-gamma activator
    • Kurtz TW. Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator. Acta Diabetol 2005; 42 (Suppl 1):S9-S16.
    • (2005) Acta Diabetol , vol.42 , Issue.SUPPL. 1
    • Kurtz, T.W.1
  • 38
    • 13944283346 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and cardiovascular remodeling
    • Schiffrin EL. Peroxisome proliferator-activated receptors and cardiovascular remodeling. Am J Physiol Heart Circ Physiol 2005; 288:H1037-H1043.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Schiffrin, E.L.1
  • 39
    • 10344249378 scopus 로고    scopus 로고
    • Antidiabetic mechanisms of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists: Beyond the rennin-angiotensin system
    • Kurtz TW, Pravenec M. Antidiabetic mechanisms of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists: beyond the rennin-angiotensin system. J Hypertens 2004; 22:2253-2261.
    • (2004) J Hypertens , vol.22 , pp. 2253-2261
    • Kurtz, T.W.1    Pravenec, M.2
  • 41
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation, atherosclerosis, and coronary artery disease
    • Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005; 352:1685-1695.
    • (2005) N Engl J Med , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 42
    • 4644372391 scopus 로고    scopus 로고
    • Inhibitory effect of candesartan and rosuvastatin on CD40 and MMPs expression in apo-E knockout mice: Novel insights into the role of RAS and dyslipidemia in atherogenesis
    • Chen J, Li D, Schaefer RF, Mehta JL. Inhibitory effect of candesartan and rosuvastatin on CD40 and MMPs expression in apo-E knockout mice: novel insights into the role of RAS and dyslipidemia in atherogenesis. J Cardiovasc Pharmacol 2004; 44:446-452.
    • (2004) J Cardiovasc Pharmacol , vol.44 , pp. 446-452
    • Chen, J.1    Li, D.2    Schaefer, R.F.3    Mehta, J.L.4
  • 43
    • 7244224783 scopus 로고    scopus 로고
    • Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis
    • Li Z, Iwai M, Wu L, Liu HW, Chen R, Jinno T, et al. Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis. Hypertension 2004; 44:758-763.
    • (2004) Hypertension , vol.44 , pp. 758-763
    • Li, Z.1    Iwai, M.2    Wu, L.3    Liu, H.W.4    Chen, R.5    Jinno, T.6
  • 44
    • 23944473130 scopus 로고    scopus 로고
    • Combined effects of HMG-CoA-reductase inhibition and renin-angiotensin system blockade on experimental atherosclerosis
    • Grothusen C, Bley S, Selle T, Luchtefeld M, Grote K, Tietge UJ, et al. Combined effects of HMG-CoA-reductase inhibition and renin-angiotensin system blockade on experimental atherosclerosis. Atherosclerosis 2005; 182:57-69.
    • (2005) Atherosclerosis , vol.182 , pp. 57-69
    • Grothusen, C.1    Bley, S.2    Selle, T.3    Luchtefeld, M.4    Grote, K.5    Tietge, U.J.6
  • 45
    • 26044452061 scopus 로고    scopus 로고
    • Effect of combined treatment with an angiotensin ii receptor antagonist and an HMG-CoA reductase inhibitor on atherosclerosis in genetically hyperlipidemic rabbits
    • Kato M, Sada T, Mizuno M, Kitayama K, Inaba T, Koike H. Effect of combined treatment with an angiotensin ii receptor antagonist and an HMG-CoA reductase inhibitor on atherosclerosis in genetically hyperlipidemic rabbits. J Cardiovasc Pharmacol 2005; 46:556-562.
    • (2005) J Cardiovasc Pharmacol , vol.46 , pp. 556-562
    • Kato, M.1    Sada, T.2    Mizuno, M.3    Kitayama, K.4    Inaba, T.5    Koike, H.6
  • 46
    • 0036023515 scopus 로고    scopus 로고
    • Treatment with atorvastatin to the National Cholesterol Educational Program goal versus 'usual' care in secondary coronary heart disease prevention. The GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) study
    • Athyros VG, Papageorgiou AA, Mercouris BR, Athyrou VV, Symeonidis AN, Basayannis EO, et al. Treatment with atorvastatin to the National Cholesterol Educational Program goal versus 'usual' care in secondary coronary heart disease prevention. The GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) study. Curr Med Res Opin 2002; 18:220-228.
    • (2002) Curr Med Res Opin , vol.18 , pp. 220-228
    • Athyros, V.G.1    Papageorgiou, A.A.2    Mercouris, B.R.3    Athyrou, V.V.4    Symeonidis, A.N.5    Basayannis, E.O.6
  • 48
    • 24644443331 scopus 로고    scopus 로고
    • Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): A multicentre randomised controlled trial
    • Dahlof B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366:895-906.
    • (2005) Lancet , vol.366 , pp. 895-906
    • Dahlof, B.1    Sever, P.S.2    Poulter, N.R.3    Wedel, H.4    Beevers, D.G.5    Caulfield, M.6


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