Apolipoprotein E*3-Leiden transgenic mice mode for hypolipidaemic drugs

Arzneimittel-Forschung/Drug Research

Volumn 48, Issue 4, 1998, Pages 396-402

  Van Vlijmen, Bart J M ^a   Pearce, Nigel J ^b   Bergö, Martin ^c   Staels, Bart ^d   Yates, John W ^b   Gribble, Andy D ^b   Bond, Brian C ^b   Hofker, Marten H ^e,g   Havekes, Louis M ^a,f   Groot, Pieter H E ^b  

^a TNO   (Netherlands)

^b GLAXOSMITHKLINE   (United Kingdom)

^c Dept of Med Biochem and Biophys ^*  (Sweden)

^d INSTITUT PASTEUR DE LILLE   (France)

^e LEIDEN UNIVERSITY   (Netherlands)

^f LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^g Netherlands Heart Foundation

Author keywords

CAS 154566 12 8; Gemfibrozil; Hypolipidaemic drugs, testing in transgenic mice; Lovastatin; SB 204990, hypolipidaemic effect; (3R*,5S*)3 Carboxy 11 (2,4 dichlorophenyl) 3,5 dihydroxyundecanoic acid, 5 ring lactone

Indexed keywords

3 CARBOXY 11 (2,4 DICHLOROPHENYL) 3,5 DIHYDROXYUNDECANOIC ACID; ANTILIPEMIC AGENT; APOLIPOPROTEIN C3; APOLIPOPROTEIN E3; CHOLESTEROL; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; MEVINOLIN; SB 204990; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; ANTICOAGULANT AGENT; APOLIPOPROTEIN E; HEPARIN; LACTONE; LIPID;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; GENE EXPRESSION; HYPERLIPIDEMIA; LIPOPROTEIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; DRUG SCREENING; GENETICS; LIVER; METABOLISM; PHYSIOLOGY;

ANIMALS; ANTICOAGULANTS; ANTILIPEMIC AGENTS; APOLIPOPROTEIN E3; APOLIPOPROTEINS E; CHOLESTEROL; DRUG EVALUATION, PRECLINICAL; GEMFIBROZIL; HEPARIN; LACTONES; LIPIDS; LIPOPROTEIN LIPASE; LIVER; LOVASTATIN; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RNA, MESSENGER; TRIGLYCERIDES;

EID: 15444342298     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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