Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 11, 2007, Pages 4105-4110

  Xu, Xiaogang ^a   Wu, Shi ^a   Ye, Xinyu ^b   Liu, Yang ^a   Shi, Wanliang ^a   Zhang, Yingyuan ^a   Wang, Minggui ^a,b  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; CEFOTAXIME; CHLORAMPHENICOL; CIPROFLOXACIN; GENTAMICIN; KANAMYCIN; LEVOFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RNA; STREPTOMYCIN; SULFAMETHOXAZOLE; TETRACYCLINE; TOBRAMYCIN; TRIMETHOPRIM;

AAC(6') IB CR GENE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM CONJUGATION; BACTERIUM ISOLATE; BACTERIUM ISOLATION; ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE; ESCHERICHIA COLI; GENE EXPRESSION; GENE MUTATION; GRAM NEGATIVE BACTERIUM; GYRA GENE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PARC GENE; PLASMID; PREVALENCE; PRIORITY JOURNAL; QNRA GENE; QNRA1 GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCREENING;

ANTI-INFECTIVE AGENTS; BASE SEQUENCE; CIPROFLOXACIN; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PLASMIDS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); QUINOLONES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 35848954103     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00616-07     Document Type: Article

References (23)

1. Cambau, E., C. Lascols, W. Scougakoff, C. Bebear, R. Bonnet, J. D. Cavallo, L. Gutmann, M. C. Ploy, V. Jarlier, C. J. Soussy, and J. Jobert. 2006. Occurrence of qnrA-positive clinical isolates in French teaching hospitals during 2002-2005. Clin. Microbiol. Infect. 12:1013-1020.
2. Clinical and Laboratory Standards Institute. 2005. Performance standards for antimicrobial susceptibility testing, 15th informational supplement (M100-S15). Clinical and Laboratory Standards Institute, Wayne, PA.
3. Corkill, J. E., J. J. Anson, and C. A. Hart. 2005. High prevalence of the plasmid-mediated quinolone resistance determinant qnrA in multidrug-resistant Enterobacteriaceae from blood cultures in Liverpool, UK. J. Antimicrob. Chemother. 56:1115-1117.
4. Fournier, B., A. Gravel, D. C. Hooper, and P. H. Roy. 1999. Strength and regulation of the different promoters for chromosomal β-lactamases of Klebsiella oxytoca. Antimicrob. Agents Chemother. 43:850-855.
5. Hata, M., M. Suzuki, M. Matsumoto, M. Takahashi, K. Sato, S. Ibe, and K. Sakae. 2005. Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b. Antimicrob. Agents Chemother. 49:801-803.
6. Jacoby, G. A. 2005. Mechanisms of resistance to quinolones. Clin. Infect. Dis. 41(Suppl. 2):S120-S126.
7. Jacoby, G. A., K. E. Walsh, D. M. Mills, V. J. Walker, Oh, H., A. Robicsek, and D. C. Hooper. 2006. qnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob. Agents Chemother. 50:1178-1182.
8. Lascols, C., J. Robert, V. Cattoir, C. Bebear, J. D. Cavallo, I. Podglajen, M. C. Ploy, R. Bonnet, C. J. Soussy, and E. Cambau. 2007. Type II topoisomerase mutations in clinical isolates of Enterobacter cloacae and other enterobacterial species harbouring the qnrA gene. Int. J. Antimicrob. Agents 29:402-409.
9. Mammeri, H., M. V. De Loo, L. Poirel, L. Martinez-Martinez, and P. Nordmann. 2005. Emergence of plasmid-mediated quinolone resistance in Escherichia coli in Europe. Antimicrob. Agents Chemother. 49:71-76.
10. Martinez-Martinez, L., A. Pascual, and G. A. Jacoby. 1998. Quinolone resistance from a transferable plasmid. Lancet 351:797-799.
11. Nordmann, P., and L. Poirel. 2005. Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae. J. Antimicrob. Chemother. 56:463-469.
12. Paauw, A., A. C. Fluit, J. Verhoef, and M. A. Leverstein-van Hall. 2006. Enterobacter cloacae outbreak and emergence of quinolone resistance gene in Dutch hospital. Emerg. Infect. Dis. 12:807-812.
13. Park, C. H., A. Robicsek, G. A. Jacoby, D. Sahm, and D. C. Hooper. 2006. Prevalence in the United States of aac(6′)-Ib-cr encoding a ciprofloxacin-modifying enzyme. Antimicrob. Agents Chemother. 50:3953-3955.
14. Perez-Perez, F. J., and N. D. Hanson. 2002. Detection of plasmid-mediated AmpC β-lactamase genes in clinical isolates by using multiplex PCR. J. Clin. Microbial. 40:2153-2162.
15. Poirel, L., J. D. Pitout, L. Calvo, J. M. Rodriguez-Martinez, D. Church, and P. Nordmann. 2006. In vivo selection of fluoroquinolone- resistant Escherichia coli isolates expressing plasmid-mediated quinolone resistance and expanded-spectrum β-lactamase. Antimicrob. Agents Chemother. 50:1525-1527.
16. Robicsek, A., G. A. Jacoby, and D. C. Hooper. 2006. The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect. Dis. 6:629-640.
17. Robicsek, A., D. F. Sahm, J. Strahilevitz, G. A. Jacoby, and D. C. Hooper. 2005. Broader distribution of plasmid-mediated quinolone resistance in the United States. Antimicrob. Agents Chemother. 49:3001-3003.
18. Robicsek, A., J. Strahilevitz, D. F. Sahm, G. A. Jacoby, and D. C. Hooper. 2006. qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States. Antimicrob. Agents Chemother. 50:2872-2874.
19. Robicsek, A., J. Strahilevitz, G. A. Jacoby, M. Macielag, D. Abbanat, C. H. Park, K. Bush, and D. C. Hooper. 2006. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat. Med. 12:83-88.
20. Rodríguez-Martínez, J. M., C. Velasco, A. Pascual, I. Garcia, and L. Martinez-Martinez. 2006. Correlation of quinolone resistance levels and differences in basal and quinolone-induced expression from three qnrA-containing plasmids. Clin. Microbiol. Infect. 12:440-445.
21. Wang, M., D. F. Sahm, G. A. Jacoby, and D. C. Hooper. 2004. Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States. Antimicrob. Agents Chemother. 48:1295-1299.
22. Wang, M., J. H. Tran, G. A. Jacoby, Y. Y. Zhang, F. Wang, and D. C. Hooper. 2003. Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China. Antimicrob. Agents Chemother. 47:2242-2248.
23. Wu, J. J., W. C. Ko, S. H. Tsai, and J. J. Yan. 2007. Prevalence of plasmid-mediated quinolone resistance determinants QnrA, QnrB, and QnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital. Antimicrob. Agents Chemother. 51:1223-1227.