Ingestion of phytosterols is not potentially hazardous [1]

Journal of Nutrition

Volumn 137, Issue 11, 2007, Pages 2485-

  Jones, Peter J H ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTELLIN; PHYTOSTEROL; PLACEBO; SIMVASTATIN; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ATHEROGENESIS; CLINICAL TRIAL; DANGEROUS GOODS; DRUG APPROVAL; DRUG BLOOD LEVEL; DRUG MEGADOSE; DRUG METABOLISM; DRUG TOLERABILITY; HUMAN; INGESTION; ISCHEMIC HEART DISEASE; LETTER; RECOMMENDED DRUG DOSE; SUPPLEMENTATION;

EID: 35848948162     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/137.11.2485     Document Type: Letter

References (8)

1. Fransen HP, de Jong N, Wolfs M, Verhagen H, Verschuren WM, Lutjohann D, von Bergmann K, Plat J, Mensink RP. Customary use of plant sterol and plant stanol enriched margarine is associated with changes in serum sterol and stanol concentrations in the human. J Nutr. 2007;137:1301-6.
2. Patel MD, Thompson PD. Phytosterols and vascular disease. Atherosclerosis. 2006;186:12-9.
3. Miettinen TA, Strandberg TE, Gylling H. Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. Arterioscler Thromb Vasc Biol. 2000;20:1340-6.
4. Chan YM, Varady KA, Lin Y, Trautwein E, Mensink RP, Plat J, Jones PJ. Plasma concentrations of plant sterols: Physiology and Relationship with Coronary Heart Disease. Nutr Rev. 2006;64:385-402.
5. Mellies MJ, Ishikawa TT, Gleuck CJ, Bove K, Morrison J. Phytosterols in aortic tissue in adults and infants. J Lab Clin Med. 1976;88:914-21.
6. Salen G, Ahrens EH, Grundy SM. Metabolism of beta-sitosterol in man. J Clin Invest. 1970;49:952-67.
7. Eli Lilly Package Insert M100 Suspension Cytellin (Beta and Di-hydro beta sitosterols). A drug product indicated for the reduction of hypercholesterolemia. Dated 1954.
8. Lea LJ, Hepburn PA. Safety evaluation of phytosterol esters. Part 9: Results of a European post-launch monitoring programme. Food Chem Toxicol. 2006;44:1213-22.