Primary and metastatic high-grade pleomorphic sarcoma/malignant fibrous histiocytoma of the gastrointestinal tract: An approach to the differential diagnosis in a series of five cases with emphasis on myofibroblastic differentiation

Virchows Archiv

Volumn 451, Issue 5, 2007, Pages 949-957

  Agaimy, Abbas ^a   Gaumann, Andreas ^b   Schroeder, Josef ^b   Dietmaier, Wolfgang ^b   Hartmann, Arndt ^b   Hofstaedter, Ferdinand ^b   Wünsch, Peter H ^a   Mentzel, Thomas ^c  

^a KLINIKUM NÜRNBERG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c Dermatopathologische Gemeinschaftspraxis   (Germany)

Author keywords

Gastrointestinal; GIST; MFH; PDGFR ; PDGFR ; Peritoneum

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER GRADING; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; FEMALE; GASTROINTESTINAL TUMOR; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LARGE INTESTINE TUMOR; MALE; MALIGNANT FIBROUS HISTIOCYTOMA; MYOFIBROBLAST; PLEOMORPHIC SARCOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMA; SMALL INTESTINE TUMOR; VISCERAL METASTASIS;

ADULT; AGED; CELL DIFFERENTIATION; DIAGNOSIS, DIFFERENTIAL; FEMALE; GASTROINTESTINAL NEOPLASMS; GASTROINTESTINAL STROMAL TUMORS; HEART NEOPLASMS; HISTIOCYTOMA, MALIGNANT FIBROUS; HUMANS; MALE; MIDDLE AGED; MUSCLE NEOPLASMS; NEOPLASM METASTASIS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; SARCOMA; STOMACH NEOPLASMS; THIGH;

EID: 35848947201     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-007-0495-3     Document Type: Article

References (46)

1. Adams HW, Adkins JR, Rehak EM (1983) Malignant fibrous histiocytoma presenting as a bleeding gastric ulcer. Am J Gastroenterol 78:212-213
2. Agaimy A, Wünsch PH (2003) Der ungewöhnliche Kolonpolyp: eine seltene Metastasierung eines Weichteilsarkoms. Chir Praxis 62:3-7
3. Agaimy A, Wünsch PH (2007) True smooth muscle neoplasms of the gastrointestinal tract: morphological spectrum and classification in a series of 85 cases from a single institute. Langenbecks Arch Surg 392:75-81
4. Agaimy A, Wünsch PH, Hofstaedter F, Blaszyk H, Rümmele P, Gaumann A, Dietmaier W, Hartmann A (2007) Minute gastric sclerosing stromal tumors (GIST Tumorlets) are common in adults and frequently show c-KIT mutations. Am J Surg Pathol 31:113-120
5. Agaimy A, Wünsch PH, Schroeder J, Gaumann A, Dietmaier W, Hartmann A, Hofstaedter F, Mentzel T (2007) Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma). Clinicopathological, immunohistochemical, molecular genetic, and ultrastructural study of two cases with literature review. J Clin Pathol (Epub ahead of print), doi: 10.1136/jcp.2007.048561
6. Akatsu Y, Saikawa Y, Kubota T, Kiyota T, Nakamura R, Akatsu T, Takahashi T, Yoshida M, Otani Y, Kumai K (2006) Metastatic gastric cancer from malignant fibrous histiocytoma: report of a case. Surg Today 36:385-389
7. Behranwala KA, Roy P, Giblin V, A'hern R, Fisher C, Thomas JM (2004) Intra-abdominal metastases from soft tissue sarcoma. J Surg Oncol 87:116-120
8. Binh MBN, Sastre-Garau X, Guillou L, de Pinieux D, Terrier P, Lagace R, Aurias A, Hostein I, Coindre JM (2005) MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well differentiated and dedifferentiated liposarcoma subtypes. A comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol 29:1340-1349
9. Blaauwwiekel EE, Koopal S, Kreeftenberg HG (1997) Metastasized malignant fibrous histiocytoma as a cause of gastrointestinal tract haemorrhage. Scand J Gastroenterol 32:1275-1276
10. Coindre JM, Mariani O, Chibon F, Mairal A, De Saint Aubain Somerhausen N, Favre-Guillevin E, Bui NB, Stoeckle E, Hostein I, Aurias A (2003) Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma. Mod Pathol 16:256-262
11. Eyden B, Christensen L (1993) Leiomyosarcoma versus myofibrosarcoma: observations and terminology. Ultrastruct Pathol 17:231-239
12. Eyden B (2001) The myofibroblast: an assessment of controversial issues and a definition useful in diagnosis and research. Ultrastruct Pathol 25:39-50
13. Eyden B, Banerjee SS (2002) Spindle-cell squamous carcinoma exhibiting myofibroblastic differentiation. A study of two cases showing fibronexus junctions. Virchows Arch 440:36-44
14. Fisher C, Goldblum JR, Montgomery E (2003) Calponin and h-caldesmon in sarcomas of myofibrobalsts. Mod Pathol 16:11A
15. Fletcher CDM (1992) Pleomorphic malignant fibrous histiocytoma: fact or fiction? A critical reappraisal based on 159 tumors diagnosed as pleomorphic sarcoma. Am J Surg Pathol 16:213-228
16. Fletcher CDM, Gustafson P, Rydholm A, Willen H, Akerman M (2001) Clinicopathologic re-evaluation of 100 malignant fibrous histiocytomas: prognostic relevance of subclassification. J Clin Oncol 19:3045-3050
17. Fletcher CDM, van den Berg E, Molenaar WM (2002) Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma. In: Fletcher CDM, Unni KK, Mertens F (eds) World Health Organization classification of tumours. Pathology and genetics. Tumours of soft tissue and bone. IARC, Lyon, pp 121-122
18. Franchi A, Massi D, Santucci M (2005) The comparative role of immunohistochemistry and electron microscopy in the identification of myogenic differentiation in soft tissue pleomorphic sarcomas. Ultrastruct Pathol 29:295-304
19. Hasegawa T, Hasegawa F, Hirose T, Sano T, Matsuno Y (2003) Expression of smooth muscle markers in so called malignant fibrous hitiocytomas. J Clin Pathol 56:666-671
20. Iesalnieks I, Rummele P, Dietmaier W, Jantsch T, Zulke C, Schlitt HJ, Hofstadter F, Anthuber M (2005) Factors associated with disease progression in patients with gastrointestinal stromal tumors in the pre-imatinib era. Am J Clin Pathol 124:740-748
21. Insabato L, Di Vizio D, Ciancia G, Pettinato G, Tornillo L, Terracciano L (2004) Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells. Arch Pathol Lab Med 128:440-443
22. Kotan C, Kosem M, Alici S, Ilhan M, Tuncer I, Harman M (2002) Primary malignant fibrous histiocytoma of the small intestine presenting as an intussusception: report of a case. Surg Today 32:1091-1095
23. Mace J, Biermann JS, Sondak V et al (2002) Response of extraabdominal desmoid tumors to therapy with imatinib mesylate. Cancer 95:2373-2379
24. Massi D, Beltrami G, Capanna R, Franchi A (2004) Histopathological reclassification of extremity pleomorphic soft tissue sarcoma has clinical relevance. Eur J Surg Oncol 30:1131-1136
25. McCormick D, Mentzel T, Beham A, Fletcher CDM (1994) Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas. Am J Surg Pathol 18:1213-1223
26. Medeiros F, Corless CL, Duensing A, Hornick JL, Oliveira AM, Heinrich MC, Fletcher JA, Fletcher CDM (2004) KIT-negative gastrointestinal stromal tumors. Proof of concept and therapeutic implications. Am J Surg Pathol 28:889-994
27. Mentzel T, Calonje E, Fletcher CD (1994) Leiomyosarcoma with prominent osteoclast-like giant cells. Analysis of eight cases closely mimicking the so-called giant cell variant of malignant fibrous histiocytoma. Am J Surg Pathol 18:258-265
28. Mentzel T, Fletcher JA (2002) Low grade myofibroblastic sarcoma. In: Fletcher CDM, Unni KK, Mertens F (eds) World Health Organization classification of tumours. Pathology and genetics. Tumours of soft tissue and bone. IARC, Lyon, pp 94-95
29. Merchant W, Calonje E, Fletcher CDM (1995) Inflammatory leiomyosarcoma: a morphological subgroup within the heterogeneous family of so-called inflammatory malignant fibrous histiocytoma. Histopathology 27:525-532
30. Miettinen M, Sarlomo-Rikala M, Kovatich AJ, Lasota J (1999) Calponin and h-caldesmon in soft tissue tumors: consistent h-caldesmon immunoreactivity in gastrointestinal stromal tumors indicates traits of smooth muscle differentiation. Mod Pathol 12:756-762
31. Montgomery E, Fisher C (2001) Myofibroblastic differentiation in malignant fibrous histiocytoma (pleomorphic myofibrosarcoma): a clinicopathologic study. Histopathology 38:499-509
32. Oda Y, Miyajima K, Kawaguchi K, Tamiya S, Oshiro Y, Hachitanda Y, Oya M, Iwamoto Y, Tsuneyoshi M (2001) Pleomorphic leiomyosarcoma: clinicopathologic and immunohistochemical study with special emphasis on its distinction from ordinary leiomyosarcoma and malignant fibrous histiocytoma. Am J Surg Pathol 25:1030-1038
33. Okuba H, Ozeki K, Tanaka T, Matsuo T, Mochinaga N (2005) Primary malignant fibrous histiocytoma of the ascending colon. Report of a case. Surg Today 35:323-327
34. Pauls K, Merkelbach-Bruse S, Thal D, Büttner R, Wardelmann E (2005) PDGFR and c-kit-mutated gastrointestinal stromal tumours (GISTs) are characterized by distinctive histological and immunohistochemical features. Histopathology 46:166-175
35. Peterson MR, Piao Z, Weidner N, Yi ES (2006) Strong PDGFRA positivity is seen in GISTs but not in other intra-abdominal mesenchymal tumors: immunohistochemical and mutational analyses. Appl Immunohistochem Mol Morphol 14:390-396
36. Roetman B, Schildhauer TA, Kuhnen C, Wardelmann E, Muhr G (2005) Polypoid pleomorphic sarcoma of the colon. Scand J Gastroenterol 40:1502-1506
37. Rossi G, Valli R, Bertolini F, Marchioni A, Cavazza A, Mucciarini C, Migali M, Federico M, Trentini GP, Sgambato A (2005) PDGFR expression in differential diagnosis between KIT-negative gastrointestinal stromal tumours and other primary soft-tissue tumours of the gastrointestinal tract. Histopathology 46:522-531
38. Sabah M, Cummins R, Leader M, Kay E (2005) Leiomyosarcoma and malignant fibrous histiocytoma share similar allelic imbalance pattern at 9p. Virchows Arch 446:251-258
39. Santoro MJ, Abdulian JD, Chase RL, Griffin RA, Solinger MR, Collen MJ (1992) Malignant fibrous histiocytoma metastatic to the colon presenting as a lower gastrointestinal bleeding. Am J Gastroenterol 87:1051-1053
40. Tamura M, Oda M, Ohta Y, Omura K, Monomura A, Watanabe G (2002) Small intestinal bleeding secondary to metastatic malignant fibrous histiocytoma of the rib: report of a case. Surg Today 32:69-71
41. Udaka T, Suzuki Y, Kimura H, Miyashita K, Suwaki T, Yoshino T (1999) Primary malignant fibrous histiocytoma of the ascending colon. Report of a case. Surg Today 29:160-164
42. Wada Y, Matsushita T, Sarumaru S, Ryo J, Isobe H, Satoh B, Kanaya S, Katayama T, Ohtoshi M (1998) Malignant fibrous histiocytoma of the stomach: report of two cases. Surg Today 28:296-300
43. Weiss SW, Enzinger FM (1978) Malignant fibrous histiocytoma: an analysis of 200 cases. Cancer 41:2250-2266
44. Wright JR Jr, Kyriakos M, DeSchryver-Kecskemeti K (1988) Malignant fibrous histiocytoma of the stomach. A report and a review of malignant fibrohistiocytic tumors of the alimentary tract. Arch Pathol Lab Med 112:251-258
45. Zambrano A, Reyes-Mugica M, Franchi A, Rosai J (2003) An osteoclast-rich tumor of the gastrointestinal tract with features resembling clear cell sarcoma of soft parts: report of 6 cases of a GIST simulator. Int J Surg Pathol 11:75-81
46. Zornig C, Thoma G, Schroder S (1990) Diffuse leiomyosarcomatosis of the colon. Cancer 65:570-572