Expression of aromatase and estrogen sulfotransferase in preinvasive and invasive breast cancer

Journal of Cancer Research and Clinical Oncology

Volumn 134, Issue 1, 2008, Pages 67-73

  Hudelist, G ^a,b   Wulfing P ^c   Kersting, C ^c   Burger, H ^c   Mattsson, B ^c   Czerwenka, K ^a   Kubista, E ^a   Gschwantler Kaulich, D ^a   Fink Retter, A ^a   Singer, C F ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b LKH Villach ^*  (Austria)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Aromatase; Epithelium; EST; Pre invasive breast cancer; Stroma

Indexed keywords

AROMATASE; ESTROGEN SULFOTRANSFERASE;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER GRADING; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE MICROARRAY; TUMOR BIOPSY;

AROMATASE; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, INTRADUCTAL, NONINFILTRATING; EPITHELIUM; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; STROMAL CELLS; SULFOTRANSFERASES; TISSUE ARRAY ANALYSIS;

EID: 35848943029     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-007-0249-2     Document Type: Article

References (23)

1. Abul-Hajj YJ, Iverson R, Kiang DT (1979) Aromatization of androgens by human breast cancer. Steroids 33:205-222
2. Bocker W, Decker T, Ruhnke M, Schneider W (1997) [Ductal hyperplasia and ductal carcinoma in situ. Definition-classification-differential diagnosis]. Pathologe 18:3-18
3. Brodie A, Lu Q, Liu Y, Long B (1999) Aromatase inhibitors and their antitumor effects in model systems. Endocr Relat Cancer 6:205-210
4. Brueggemeier RW, Hackett JC, Diaz-Cruz ES (2005) Aromatase inhibitors in the treatment of breast cancer. Endocr Rev 26:331-345
5. Bulun SE, Price TM, Aitken J, Mahendroo MS, Simpson ER (1993) A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. J Clin Endocrinol Metab 77:1622-1628
6. Dowsett M, Cuzick J, Wale C, Howell T, Houghton J, Baum M (2005) Retrospective analysis of time to recurrence in the ATAC trial according to hormone receptor status: an hypothesis-generating study. J Clin Oncol 23:7512-7517
7. Geisler J (2003) Breast cancer tissue estrogens and their manipulation with aromatase inhibitors and inactivators. J Steroid Biochem Mol Biol 86:245-253
8. Geisler J, Lonning PE (2005) Aromatase inhibition: translation into a successful therapeutic approach. Clin Cancer Res 11:2809-2821
9. Howell A, Cuzick J, Baum M, Buzdar A, Dowsett M, Forbes JF, Hoctin-Boes G, Houghton J, Locker GY, Tobias JS (2005) Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet 365:60-62
10. Lipton A, Santner SJ, Santen RJ, Harvey HA, Feil PD, White-Hershey D, Bartholomew MJ, Antle CE (1987) Aromatase activity in primary and metastatic human breast cancer. Cancer 59:779-782
11. Lu Q, Nakmura J, Savinov A, Yue W, Weisz J, Dabbs DJ, Wolz G, Brodie A (1996) Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers. Endocrinology 137:3061-3068
12. Moriya T, Silverberg SG (1994) Intraductal carcinoma (ductal carcinoma in situ) of the breast. A comparison of pure noninvasive tumors with those including different proportions of infiltrating carcinoma. Cancer 74:2972-2978
13. Pasqualini JR, Chetrite GS (2005) Recent insight on the control of enzymes involved in estrogen formation and transformation in human breast cancer. J Steroid Biochem Mol Biol 93:221-236
14. Remmele W, Stegner HE (1987) [Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue]. Pathologe 8:138-140
15. Santner SJ, Feil PD, Santen RJ (1984) In situ estrogen production via the estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway. J Clin Endocrinol Metab 59:29-33
16. Sasano H, Nagura H, Harada N, Goukon Y, Kimura M (1994) Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders. Hum Pathol 25:530-535
17. Sasano H, Frost AR, Saitoh R, Harada N, Poutanen M, Vihko R, Bulun SE, Silverberg SG, Nagura H (1996) Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma. J Clin Endocrinol Metab 81:4042-4046
18. Singer CF, Fink-Retter A, Gschwantler-Kaulich D, Thalhammer T, Hudelist G, Mueller R, Czerwenka K, Kubista E (2006) Related Articles, Links Selective spatial upregulation of intratumoral stromal aromatase in breast cancer patients: evidence for imbalance of local estrogen metabolism. Endocr Relat Cancer 13(4):1101-1107
19. Suzuki T, Nakata T, Miki Y, Kaneko C, Moriya T, Ishida T, Akinaga S, Hirakawa H, Kimura M, Sasano H (2003) Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma. Cancer Res 63:2762-2770
20. Suzuki T, Miki Y, Nakamura Y, Moriya T, Ito K, Ohuchi N, Sasano H (2005) Sex steroid-producing enzymes in human breast cancer. Endocr Relat Cancer 12:701-720
21. van Landeghem AA, Poortman J, Nabuurs M, Thijssen JH (1985) Endogenous concentration and subcellular distribution of androgens in normal and malignant human breast tissue. Cancer Res 45:2907-2912
22. Vermeulen A, Deslypere JP, Paridaens R, Leclercq G, Roy F, Heuson JC (1986) Aromatase, 17 beta-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women. Eur J Cancer Clin Oncol 22:515-525
23. Zhang Z, Yamashita H, Toyama T, Hara Y, Omoto Y, Sugiura H, Kobayashi S, Harada N, Iwase H (2002) Semi-quantitative immunohistochemical analysis of aromatase expression in ductal carcinoma in situ of the breast. Breast Cancer Res Treat 74:47-53