Preproghrelin Leu72Met polymorphism in Chinese subjects with coronary artery disease and controls

Clinica Chimica Acta

Volumn 387, Issue 1-2, 2008, Pages 42-47

  Tang, Na Ping ^a   Wang, Lian Sheng ^a   Yang, Li ^a   Gu, Hai Juan ^a   Zhu, Huai Jun ^a   Zhou, Bo ^a   Sun, Qing Min ^a   Cong, Ri Hong ^a   Wang, Bin ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Coronary artery disease; Ghrelin; Polymorphism; Preproghrelin

Indexed keywords

CHOLESTEROL; GHRELIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEUCINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METHIONINE; PREPROGHRELIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CHINA; CHINESE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DIET RESTRICTION; DYSLIPIDEMIA; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GLUCOSE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; PHENOTYPE; PRIORITY JOURNAL;

AGED; BLOOD GLUCOSE; BODY MASS INDEX; CASE-CONTROL STUDIES; CHINA; CORONARY ARTERY DISEASE; FEMALE; GHRELIN; HUMANS; LEUCINE; LIPIDS; MALE; METHIONINE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, GENETIC; PROTEIN PRECURSORS;

EID: 35748983840     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2007.08.014     Document Type: Article

References (35)

1. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
2. Wren A.M., Small C.J., Ward H.L., et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141 (2000) 4325-4328
3. Tschop M., Smiley D.L., and Heiman M.L. Ghrelin induces adiposity in rodents. Nature 407 (2000) 908-913
4. Shiiya T., Nakazato M., Mizuta M., et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 87 (2002) 240-244
5. Tschop M., Weyer C., Tataranni P.A., Devanarayan V., Ravussin E., and Heiman M.L. Circulating ghrelin levels are decreased in human obesity. Diabetes 50 (2001) 707-709
6. Yildiz B.O., Suchard M.A., Wong M.L., McCann S.M., and Licinio J. Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. Proc Natl Acad Sci U S A 101 (2004) 10434-10439
7. Li W.G., Gavrila D., Liu X., et al. Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation 109 (2004) 2221-2226
8. Sharma V., and McNeill J.H. The emerging roles of leptin and ghrelin in cardiovascular physiology and pathophysiology. Curr Vasc Pharmacol 3 (2005) 169-180
9. Tesauro M., Schinzari F., Iantorno M., et al. Ghrelin improves endothelial function in patients with metabolic syndrome. Circulation 112 (2005) 2986-2992
10. Baldanzi G., Filigheddu N., Cutrupi S., et al. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol 159 (2002) 1029-1037
11. Wajanrajch M.P., Ten I.S., Gertner J.M., and Leibel R.L. Genomic organization of human ghrelin gene. J Endocr Genet 1 (2000) 231-233
12. Ukkola O., Ravussin E., Jacobson P., et al. Mutations in the preproghrelin/ghrelin gene associated with obesity in humans. J Clin Endocrinol Metab 86 (2001) 3996-3999
13. Kuzuya M., Ando F., Iguchi A., and Shimokata H. Preproghrelin Leu72Met variant contributes to overweight in middle-aged men of a Japanese large cohort. Int J Obes (Lond) 30 (2006) 1609-1614
14. Korbonits M., Gueorguiev M., O'Grady E., et al. A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. J Clin Endocrinol Metab 87 (2002) 4005-4008
15. Miraglia del Giudice E., Santoro N., Cirillo G., et al. Molecular screening of the ghrelin gene in Italian obese children: the Leu72Met variant is associated with an earlier onset of obesity. Int J Obes Relat Metab Disord 28 (2004) 447-450
16. Mager U., Lindi V., Lindstrom J., et al. Association of the Leu72Met polymorphism of the ghrelin gene with the risk of Type 2 diabetes in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study. Diabet Med 23 (2006) 685-689
17. Steinle N.I., Pollin T.I., O'Connell J.R., Mitchell B.D., and Shuldiner A.R. Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish. J Clin Endocrinol Metab 90 (2005) 6672-6677
18. Ando T., Komaki G., Naruo T., et al. Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa. Am J Med Genet B Neuropsychiatr Genet 141 (2006) 929-934
19. Monteleone P., Tortorella A., Castaldo E., Di Filippo C., and Maj M. The Leu72Met polymorphism of the ghrelin gene is significantly associated with binge eating disorder. Psychiatr Genet 17 (2007) 13-16
20. Jo D.S., Kim S.L., Kim S.Y., Hwang P.H., Lee K.H., and Lee D.Y. Preproghrelin Leu72Met polymorphism in obese Korean children. J Pediatr Endocrinol Metab 18 (2005) 1083-1086
21. Larsen L.H., Gjesing A.P., Sorensen T.I., et al. Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes. Clin Biochem 38 (2005) 420-424
22. Ukkola O., Ravussin E., Jacobson P., et al. Role of ghrelin polymorphisms in obesity based on three different studies. Obes Res 10 (2002) 782-791
23. Choi H.J., Cho Y.M., Moon M.K., et al. Polymorphisms in the ghrelin gene are associated with serum high-density lipoprotein cholesterol level and not with type 2 diabetes mellitus in Koreans. Endocrinol Metab 91 (2006) 4657-4663
24. Kim S.Y., Jo D.S., Hwang P.H., et al. Preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus. Metabolism 55 (2006) 366-370
25. Hubacek J.A., Bloudickova S., Bohuslavova R., et al. Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients. Clin Chem Lab Med (Jul 19 2007) [Electronic publication ahead of print]
26. Bing C., Ambye L., Fenger M., et al. Large-scale studies of the Leu72Met polymorphism of the ghrelin gene in relation to the metabolic syndrome and associated quantitative traits. Diabet Med 22 (2005) 1157-1160
27. Monteleone P., Tortorella A., Castaldo E., Di Filippo C., and Maj M. No association of the Arg51Gln and Leu72Met polymorphisms of the ghrelin gene with anorexia nervosa or bulimia nervosa. Neurosci Lett 398 (2006) 325-327
28. Wagner K., Hemminki K., Grzybowska E., et al. Polymorphisms in genes involved in GH1 release and their association with breast cancer risk. Carcinogenesis 27 (2006) 1867-1875
29. Skibola D.R., Smith M.T., Bracci P.M., et al. Polymorphisms in ghrelin and neuropeptide Y genes are associated with non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 14 (2005) 1251-1256
30. Lee D.Y., Kim S.Y., Jo D.S., et al. Preproghrelin Leu72Met polymorphism predicts a lower rate of developing renal dysfunction in type 2 diabetic nephropathy. Eur J Endocrinol 155 (2006) 187-190
31. Mager U., Kolehmainen M., Lindstrom J., et al. Association between ghrelin gene variations and blood pressure in subjects with impaired glucose tolerance. Am J Hypertens 19 (2006) 920-926
32. Ukkola O., and Kesaniemi Y.A. Preproghrelin Leu72Met polymorphism in patients with type 2 diabetes mellitus. J Intern Med 254 (2003) 391-394
33. Wang B., Pan J., Wang L., Zhu H., Yu R., and Zou Y. Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease. Atherosclerosis 184 (2006) 425-430
34. Zhu H., Yang L., Zhou B., Yu R., Tang N., and Wang B. Myeloperoxidase G-463A polymorphism and the risk of gastric cancer: a case-control study. Carcinogenesis 27 (2006) 2491-2496
35. Wang L.S., Tang N.P., Zhu H.J., Zhou B., Yang L., and Wang B. Endothelin-converting enzyme-1b C-338A polymorphism is associated with the increased risk of coronary artery disease in Chinese population. Clin Chim Acta 384 (2007) 75-79