Role of LPS in the hepatic microvascular dysfunction elicited by cecal ligation and puncture in mice

Journal of Hepatology

Volumn 47, Issue 6, 2007, Pages 799-806

  Singer, Georg ^a   Houghton, Jeff ^b   Rivera, Chantal A ^b   Anthoni, Christoph ^b   Granger, D N ^b  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Intravital fluorescence microscopy; Liver injury; LPS; Platelets; Sepsis; TLR 4

Indexed keywords

LIPOPOLYSACCHARIDE; MESSENGER RNA; TOLL LIKE RECEPTOR 2;

ARTICLE; BLOOD CELL COUNT; CELL ADHESION; CONTROLLED STUDY; LIGATION; LIVER DYSFUNCTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS;

ANIMALS; BLOOD PLATELETS; CELL ADHESION; DISEASE MODELS, ANIMAL; ENDOTOXINS; LEUKOCYTES; LIPOPOLYSACCHARIDES; LIVER CIRCULATION; LIVER DISEASES; MICE; MICROCIRCULATION; MICROSCOPY, VIDEO; SEPSIS;

EID: 35748977124     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2007.07.021     Document Type: Article

References (34)

1. Angus D.C., Linde-Zwirble W.T., Lidicker J., Clermont G., Carcillo J., and Pinsky M.R. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29 (2001) 1303-1310
2. Fry D.E., Pearlstein L., Fulton R.L., and Polk Jr. H.C. Multiple system organ failure. The role of uncontrolled infection. Arch Surg 115 (1980) 136-140
3. Beal A.L., and Cerra F.B. Multiple organ failure syndrome in the 1990s. Systemic inflammatory response and organ dysfunction. JAMA 271 (1994) 226-233
4. Eipel C., Bordel R., Nickels R.M., Menger M.D., and Vollmar B. Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia. Am J Physiol Gastrointest Liver Physiol 286 (2004) G769-G776
5. Salkowski C.A., Detore G., Franks A., Falk M.C., and Vogel S.N. Pulmonary and hepatic gene expression following cecal ligation and puncture: monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration. Infect Immun 66 (1998) 3569-3578
6. Russwurm S., Vickers J., Meier-Hellmann A., Spangenberg P., Bredle D., Reinhart K., et al. Platelet and leukocyte activation correlate with the severity of septic organ dysfunction. Shock 17 (2002) 263-268
7. Garrido A.G., Poli de Figueiredo L.F., and Rocha e Silva M. Experimental models of sepsis and septic shock: an overview. Acta Cirurg Brasil 19 (2004) 82-88
8. Remick D.G., Newcomb D.E., Bolgos G.L., and Call D.R. Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture. Shock 13 (2000) 110-116
9. Villa P., Sartor G., Angelini M., Sironi M., Conni M., Gnocchi P., et al. Pattern of cytokines and pharmacomodulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin. Clin Diagn Lab Immunol 2 (1995) 549-553
10. Croner R.S., Hoerer E., Kulu Y., Hackert T., Gebhard M.M., Herfarth C., et al. Hepatic platelet and leukocyte adherence during endotoxemia. Crit Care 10 (2006) R15
11. Lush C.W., and Kvietys P.R. Microvascular dysfunction in sepsis. Microcirculation 7 (2000) 83-101
12. Sorkine P., Szold O., Halpern P., Gutman M., Greemland M., Rudick V., et al. Gut decontamination reduces bowel ischemia-induced lung injury in rats. Chest 112 (1997) 491-495
13. Hiramatsu M., Hotchkiss R.S., Karl I.E., and Buchman T.G. Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway. Shock 7 (1997) 247-253
14. Bauer P., Russell J.M., and Granger D.N. Role of endotoxin in intestinal reperfusion-induced expression of E-selectin. Am J Physiol 276 (1999) G479-G484
15. Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol 1 (2001) 135-145
16. Miller S.I., Ernst R.K., and Bader M.W. LPS, TLR4 and infectious disease diversity. Nat Rev Microbiol 3 (2005) 36-46
17. Gangloff M., and Gay N.J. MD-2: the Toll 'gatekeeper' in endotoxin signalling. Trends Biochem Sci 29 (2004) 294-300
18. Nagai Y., Akashi S., Nagafuku M., Ogata M., Iwakura Y., Akira S., et al. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol 3 (2002) 667-672
19. Bauer P., Lush C.W., Kvietys P.R., Russell J.M., and Granger D.N. Role of endotoxin in the expression of endothelial selectins after cecal ligation and perforation. Am J Physiol Regul Integr Comp Physiol 278 (2000) R1140-R1147
20. Tailor A., Lefer D.J., and Granger D.N. HMG-CoA reductase inhibitor attenuates platelet adhesion in intestinal venules of hypercholesterolemic mice. Am J Physiol Heart Circ Physiol 286 (2004) H1402-H1407
21. Singer G., Urakami H., Specian R.D., Stokes K.Y., and Granger D.N. Platelet recruitment in the murine hepatic microvasculature during experimental sepsis: role of neutrophils. Microcirculation 13 (2006) 89-97
22. Massberg S., Eisenmenger S., Enders G., Krombach F., and Messmer K. Quantitative analysis of small intestinal microcirculation in the mouse. Res Exp Med (Berl) 198 (1998) 23-35
23. Rivera C.A., and Thurman R.G. Tips for measuring endotoxin in plasma. Alcohol Clin Exp Res 22 (1998) 2192-2194
24. Palsson-McDermott E.M., and O'Neill L.A. Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 113 (2004) 153-162
25. Akashi S., Shimazu R., Ogata H., Nagai Y., Takeda K., Kimoto M., et al. Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J Immunol 164 (2000) 3471-3475
26. Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162 (1999) 3749-3752
27. Matsumoto Y., Ito Y., Hayashi I., Majima M., Ishii K., Katagiri H., et al. Effect of FR167653, a novel inhibitor of tumor necrosis factor-alpha and interleukin-1beta synthesis on lipopolysaccharide-induced hepatic microvascular dysfunction in mice. Shock 17 (2002) 411-415
28. Vianna R.C., Gomes R.N., Bozza F.A., Amancio R.T., Bozza P.T., David C.M., et al. Antibiotic treatment in a murine model of sepsis: impact on cytokines and endotoxin release. Shock 21 (2004) 115-120
29. Matsuguchi T., Musikacharoen T., Ogawa T., and Yoshikai Y. Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages. J Immunol 165 (2000) 5767-5772
30. Williams D.L., Ha T., Li C., Kalbfleisch J.H., Schweitzer J., Vogt W., et al. Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality. Crit Care Med 31 (2003) 1808-1818
31. Shimazu R., Akashi S., Ogata H., Nagai Y., Fukudome K., Miyake K., et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 189 (1999) 1777-1782
32. Weighardt H., Kaiser-Moore S., Vabulas R.M., Kirschning C.J., Wagner H., and Holzmann B. Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection. J Immunol 169 (2002) 2823-2827
33. Echtenacher B., Weigl K., Lehn N., and Mannel D.N. Tumor necrosis factor-dependent adhesions as a major protective mechanism early in septic peritonitis in mice. Infect Immun 69 (2001) 3550-3555
34. Hoesel M., Neff T.A., Neff S.B., Younger J.G., Olle E.W., Gao H., et al. Harmful and protective roles of neutrophils in sepsis. Shock 24 (2005) 40-47