Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections

Journal of Immunology

Volumn 179, Issue 6, 2007, Pages 3535-3542

  Ely, Kenneth H ^a   Ahmed, Mushtaq ^a   Kohlmeier, Jacob E ^a   Roberts, Alan D ^a   Wittmer, Susan T ^a   Blackman, Marcia A ^a   Woodland, David L ^a  

^a TRUDEAU INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; EPITOPE; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNOSTIMULATION; INFLUENZA VIRUS; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PARAINFLUENZA VIRUS; PHENOTYPE; PRIORITY JOURNAL; VIRAL RESPIRATORY TRACT INFECTION; ACUTE DISEASE; AGING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CLONE; CELL PROLIFERATION; IMMUNOLOGY; INFLUENZA VIRUS A H3N2; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; ORTHOMYXOVIRUS INFECTION; PATHOLOGY; RESPIRATORY TRACT INFECTION; RNA VIRUS INFECTION; SENDAI VIRUS; T LYMPHOCYTE SUBPOPULATION; VIROLOGY;

ACUTE DISEASE; AGING; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CLONE CELLS; EPITOPES, T-LYMPHOCYTE; FEMALE; INFLUENZA A VIRUS, H3N2 SUBTYPE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MICE; MICE, INBRED C57BL; ORTHOMYXOVIRIDAE INFECTIONS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RESPIRATORY TRACT INFECTIONS; RESPIROVIRUS INFECTIONS; SENDAI VIRUS; T-LYMPHOCYTE SUBSETS;

EID: 35748976568     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.6.3535     Document Type: Article

References (28)

1. LeMaoult, J., I. Messaoudi, J. S. Manavalan, H. Potvin, D. Nikolich-Zugich, R. Dyall, P. Szabo, M. E. Weksler, and J. Nikolich-Zugich. 2000. Age-related dysregulation in CD8 T cell homeostasis: kinetics of a diversity loss. J. Immunol. 165: 2367-2373.
2. Wick, G., P. Jansen-Durr, P. Berger, I. Blasko, and B. Grubeck-Loebenstein. 2000. Diseases of aging. Vaccine 18: 1567-1583.
3. Miller, R. A. 1996. The aging immune system: primer and prospectus. Science 273: 70-74.
4. Haynes, L., J. Cambier, and R. Fulder. 2005. Aging and immune function: summary of a workshop held at Trudeau Institute, Saranac Lake, NY. Mech. Ageing Dev. 126: 822-825.
5. Callahan, J. E., J. W. Kappler, and P. Marrack. 1993. Unexpected expansions of CD8-bearing cells in old mice. J. Immunol. 151: 6657-6669.
6. + subset in normal human subjects. J. Immunol. 151: 5762-5769.
7. Posnett, D. N., R. Sinha, S. Kabak, and C. Russo. 1994. Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy". J. Exp. Med. 179: 609-618.
8. + memory T cells in aged individuals. Immunol. Rev. 205: 170-189.
9. Messaoudi, I., J. Lemaoult, J. A. Guevara-Patino, B. M. Metzner, and J. Nikolich-Zugich. 2004. Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense. J. Exp. Med. 200: 1347-1358.
10. + T cells in aged mice. Ann. NY Acad. Sci. 987: 274-279.
11. Effros, R. B., Z. Cai, and P. J. Linton. 2003. CD8 T cells and aging. Crit. Rev. Immunol. 23: 45-64.
12. Khan, N., N. Shariff, M. Cobbold, R. Bruton, J. A. Ainsworth, A. J. Sinclair, L. Nayak, and P. A. Moss. 2002. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J. Immunol. 169: 1984-1992.
13. Koch, S., R. Solana, O. Dela Rosa, and G. Pawelec. 2006. Human cytomegalovirus infection and T cell immunosenescence: a mini review. Mech. Ageing Dev. 127: 538-543.
14. + T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals. J. Immunol. 177: 2784-2792.
15. + T cells. J. Immunol. 149: 1319-1325.
16. + T cells. J. Exp. Med. 174: 875-880.
17. Pannetier, C., M. Cochet, S. Darche, A. Casrouge, M. Zoller, and P. Kourilsky. 1993. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor β chains vary as a function of the recombined germ-line segments. Proc. Natl. Acad. Sci. USA 90: 4319-4323.
18. Usherwood, E. J., T. L. Hogg, and D. L. Woodland. 1999. Enumeration of antigen-presenting cells in mice infected with Sendai virus. J. Immunol. 162: 3350-3355.
19. Roberts, A. D., K. H. Ely, and D. L. Woodland. 2005. Differential contributions of central and effector memory T cells to recall responses. J. Exp. Med. 202: 123-133.
20. Cole, G. A., T. L. Hogg, and D. L. Woodland. 1994. The MHC class I-restricted T cell response to Sendai virus infection in C57BL/6 mice: a single immunodominant epitope elicits an extremely diverse repertoire of T cells. Int. Immunol. 6: 1767-1775.
21. + T cells without selection of higher affinity TCR. Nat. Immunol. 2: 711-717.
22. Schluns, K. S., and L. Lefrancois. 2003. Cytokine control of memory T-cell development and survival. Nat. Rev. Immunol. 3: 269-279.
23. Belz, G. T., W. Xie, J. D. Altman, and P. C. Doherty. 2000. A previously unrecognized H-2D(b) -restricted peptide prominent in the primary influenza A virus-specific CD8+ T-cell response is much less apparent following secondary challenge. J. Virol. 74: 3486-3493.
24. b-restricted response to an influenza A virus nucleoprotein epitope. J. Immunol. 151: 2658-2666.
25. + T cell response. Immunity 18: 549-559.
26. Jelley-Gibbs, D. M., D. M. Brown, J. P. Dibble, L. Haynes, S. M. Eaton, and S. L. Swain. 2005. Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation. J. Exp. Med. 202: 697-706.
27. Zammit, D. J., D. L. Turner, K. D. Klonowski, L. Lefrancois, and L. S. Cauley. 2006. Residual antigen presentation after influenza virus infection affects CD8 T cell activation and migration. Immunity 24: 439-449.
28. Woodland, D. L., and M. A. Blackman. 2006. Immunity and age: living in the past? Trends Immunol. 27: 303-307.