Antiepileptic drug exposure and major congenital malformations: The role of pregnancy registries

Epilepsy and Behavior

Volumn 11, Issue 3, 2007, Pages 277-282

  Tomson, Torbjörn ^a   Battino, Dina ^b   French, Jacqueline ^c   Harden, Cynthia ^d   Holmes, Lewis ^e   Morrow, Jim ^f   Robert Gnansia, Elisabeth ^g   Scheuerle, Angela ^h   Vajda, Frank ⁱ   Wide, Katarina ^a   Gordon, Jacki ^j  

^a KAROLINSKA INSTITUTE   (Sweden)

^b DEPARTMENT OF NEUROSURGERY   (Italy)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f ROYAL GROUP OF HOSPITALS   (United Kingdom)

^g UNIVERSITÉ LYON 1   (France)

^h Tesserae Genetics Texas   (United States)

ⁱ UNIVERSITY OF MELBOURNE   (Australia)

^j Epilepsy Therapy Development Project   (United States)

more..

Author keywords

Antiepileptic drugs; Epilepsy; Malformations; Pregnancy; Teratogenicity

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETIRACETAM; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID;

ALCOHOL CONSUMPTION; ARTICLE; CIGARETTE SMOKING; CLEFT LIP; CLEFT LIP FACE PALATE; COGNITION; CONGENITAL HEART MALFORMATION; CONGENITAL MALFORMATION; DATA ANALYSIS; DISEASE ASSOCIATION; DISEASE REGISTRY; DRUG INDUSTRY; EPILEPSY; FIRST TRIMESTER PREGNANCY; HUMAN; INFORMATION PROCESSING; INFORMED CONSENT; LABOR; LICENCE; MATERNAL BEHAVIOR; MEDICAL RESEARCH; METHODOLOGY; NEURAL TUBE DEFECT; OUTCOME ASSESSMENT; PATIENT CARE; PATIENT SELECTION; PHARMACOGENETICS; PREGNANCY; PREGNANCY OUTCOME; PRENATAL DRUG EXPOSURE; RESEARCH SUBJECT; SWEDEN; TERATOGENICITY; TREATMENT OUTCOME;

ABNORMALITIES, DRUG-INDUCED; ANTICONVULSANTS; EPILEPSY; FEMALE; HUMANS; ODDS RATIO; PREGNANCY; PREGNANCY COMPLICATIONS; REGISTRIES; RISK FACTORS; SWEDEN;

EID: 35748946919     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2007.08.015     Document Type: Article

References (16)

1. Barrett C., and Richens A. Epilepsy and pregnancy: report of an Epilepsy Research Foundation Workshop. Epilepsy Res 52 (2003) 147-187
2. Tomson T., and Battino D. Teratogenicity of antiepileptic drugs: state of the art. Curr Opin Neurol 18 (2005) 135-140
3. Wide K., Winbladh B., and Kallen B. Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study. Acta Paediatr 93 (2004) 174-176
4. Artama M., Auvinen A., Raudaskoski T., Isojarvi I., and Isojarvi J. Antiepileptic drug use of women with epilepsy and congenital malformations in offspring. Neurology 64 (2005) 1874-1878
5. Holmes L.B., Wyszynski D.F., and Lieberman E.S. The AED (antiepileptic drug) Pregnancy Registry: a 6-year experience. Arch Neurol 61 (2004) 673-678
6. Wyszynski D.F., Nambisan M., Surve T., Alsdorf R.M., Smith C.R., and Holmes L.B. Increased rate of major malformations in offspring exposed to valproate during pregnancy. Neurology 64 (2005) 961-965
7. Holmes L.B., Wyszynski D.F., Baldwin E.J., Habecker E., Glassman L.H., and Smith C.R. Increased risk for non-syndromic cleft palate among infants exposed to lamotrigine during pregnancy. Birth Def Res (Pt A) Clin Mol Teratol 76 (2006) 318
8. Hernandez-Diaz S., Smith C.R., Wyszynski D.F., and Holmes L.B. Risk of major malformations among infants exposed to carbamazepine during pregnancy. Birth Def Res (Pt A): Clin Mol Teratol 79 (2007) 357
9. Nelson K., and Holmes L.B. Malformations due to presumed spontaneous mutations in newborn infants. N Engl J Med 320 (1989) 19-23
10. Morrow J.I., Russell A., Gutherie E., et al. Malformation risks of anti-epileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 77 (2006) 193-198
11. Hunt S., Craig J., Russell A., et al. Levetiracetam in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register. Neurology 67 (2006) 1876-1879
12. Vajda F.J.E., Hitchcock A., Graham J., et al. Foetal malformations and seizure control: 52 months data of the Australian Pregnancy Registry. Eur J Neurol 13 (2006) 644-645
13. European and International Registry of Antiepileptic Drugs and Pregancy (EURAP) Study Group. Seizure control and treatment in pregnancy: observations from the EURAP Epilepsy Pregnancy Registry. Neurology 2006;66:354-360.
14. European and International Registry of Antiepileptic Drugs and Pregancy (EURAP) interim report, November 2006. Available at: http://eurapinternational.org.
15. Cunnington M., Ferber S., Quarteny G., and and the International Lamotrigine Pregnancy Registry Scientific Advisory Committee. Effect of dose on frequency of major birth defects following fetal exposure to lamotrigine monotherapy in an international observational study. Epilepsia 48 (2007) 1207-1210
16. Beghi E., Annegers J.F., and Collaborative Group for Pregnancy Registries in Epilepsy. Pregnancy registries in epilepsy. Epilepsia 42 (2001) 1422-1425