Role of megalin, a proximal tubular endocytic receptor, in calcium and phosphate homeostasis

Therapeutic Apheresis and Dialysis

Volumn 11, Issue SUPPL. 1, 2007, Pages

  Saito, Akihiko ^a   Iino, Noriaki ^a   Takeda, Tetsuro ^a   Gejyo, Fumitake ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

Calcium; Diabetes; Megalin; Phosphate; Proximal tubule

Indexed keywords

CALCIUM; MEGALIN; PARATHYROID HORMONE; PHOSPHATE; VITAMIN D;

CALCIUM HOMEOSTASIS; CONFERENCE PAPER; ENDOCYTOSIS; HUMAN; HYPERPHOSPHATURIA; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; KNOCKOUT MOUSE; METABOLIC DISORDER; NONHUMAN; PHOSPHATE METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; URINARY TRACT DISEASE; VITAMIN D METABOLISM;

ANIMALS; CALCIUM; HOMEOSTASIS; HUMANS; LDL-RECEPTOR RELATED PROTEIN 2; LIGANDS; MICE; PARATHYROID HORMONE; PHOSPHATES; VITAMIN D;

EID: 35748946007     PISSN: 17449979     EISSN: 17449987     Source Type: Journal    
DOI: 10.1111/j.1744-9987.2007.00514.x     Document Type: Conference Paper

References (13)

1. Kerjaschki D, Farquhar MG. The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci USA 1982 79: 5557 61.
2. Saito A, Pietromonaco S, Loo AK, Farquhar MG. Complete cloning and sequencing of rat gp330/"megalin", a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci USA 1994 91: 9725 9.
3. May P, Woldt E, Matz RL, Boucher P. The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions. Ann Med 2007 39: 219 28.
4. Biemesderfer D. Regulated intramembrane proteolysis of megalin: linking urinary protein and gene regulation in proximal tubule? Kidney Int 2006 69: 1717 21.
5. Christensen EI, Birn H. Megalin and cubilin: multifunctional endocytic receptors. Nat Rev Mol Cell Biol 2002 3: 256 66.
6. Oyama Y, Takeda T, Hama H et al. Evidence for megalin-mediated proximal tubular uptake of L-FABP, a carrier of potentially nephrotoxic molecules. Lab Invest 2005 85: 522 31.
7. Leheste JR, Rolinski B, Vorum H et al. Megalin knockout mice as an animal model of low molecular weight proteinuria. Am J Pathol 1999 155: 1361 70.
8. Willnow TE, Hilpert J, Armstrong SA et al. Defective forebrain development in mice lacking gp330/megalin. Proc Natl Acad Sci USA 1996 93: 8460 4.
9. Nykjaer A, Dragun D, Walther D et al. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 1999 96: 507 15.
10. Leheste JR, Melsen F, Wellner M et al. Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J 2003 17: 247 9.
11. Nykjaer A, Fyfe JC, Kozyraki R et al. Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25 (OH) vitamin D (3). Proc Natl Acad Sci USA 2001 98: 13895 900.
12. Levin A, Bakris GL, Molitch M et al. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int 2007 71: 31 8.
13. Jentsch TJ. Chloride transport in the kidney: lessons from human disease and knockout mice. J Am Soc Nephrol 2005 16: 1549 61.