Neuroprotection in cerebral infarction: The opportunity of new studies

Cerebrovascular Diseases

Volumn 24, Issue SUPPL. 1, 2007, Pages 153-156

  Pérez De La Ossa, Natalia ^a   Dávalos, Antoni ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

Acute stroke; Cerebral ischemia; Neuroprotection

Indexed keywords

3 (5 CHLORO 2 METHOXYPHENYL) 3 FLUORO 2,3 DIHYDRO 6 TRIFLUOROMETHYL 1H INDOL 2 ONE; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 4 PHOSPHONOMETHYLPIPECOLIC ACID; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ARUNDIC ACID; CITICOLINE; CLOMETHIAZOLE; DISUFENTON SODIUM; ELIPRODIL; FIBRINOLYTIC AGENT; FIBROBLAST GROWTH FACTOR; FOSPHENYTOIN SODIUM; GAVESTINEL; GLUTAMATE RECEPTOR ANTAGONIST; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; LUBELUZOLE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; NEUTROPHIL INHIBITORY FACTOR; NIMODIPINE; NITRIC OXIDE DONOR; PROPIONIC ACID DERIVATIVE; RECOMBINANT BASIC FIBROBLAST GROWTH FACTOR; REPINOTAN; SCAVENGER; SEROTONIN 1A AGONIST; SEROTONIN AGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZONAMPANEL;

BLOOD CLOT LYSIS; BRAIN INFARCTION; CLINICAL TRIAL; CONFERENCE PAPER; DISEASE COURSE; DRUG EFFICACY; HUMAN; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REPERFUSION INJURY; STROKE;

ACUTE DISEASE; CEREBRAL INFARCTION; HUMANS; NEUROPROTECTIVE AGENTS; STROKE;

EID: 35649019688     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000107391     Document Type: Conference Paper

References (16)

1. O'Collins V, Macleod M, Donnan G, Horky L, van der Worp B, Howells D: 1,026 experimental treatments in acute stroke. Ann Neurol 2006;59:467-477.
2. Wahlgren NG, Ahmed N: Neuroprotection in cerebral ischemia: facts and fancies - the need for new approaches. Cerebrovasc Dis 2004;17(suppl 1):153-166.
3. Stroke Therapy Academia Industry Roundtable II (STAIR II): Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 2001;32:1598-1606.
4. Lees KR, Zivin JA, Ashwood T, Davalos A, Davis SM, Diener HC, Grotta J, Lyden P, Shuaib A, Hardemark HG, Wasieski WW: NXY-059 for acute ischemic stroke. N Engl J Med 2006;354:588-600.
5. Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, Diener HC, Ashwood T, Wasiewski W, Ugochi E: NXY-059 for acute ischemic stroke: results of the SAINT II trial. N Engl J Med 2007;357:562-571.
6. Savitz SI, Fisher M: Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials. Ann Neurol 2007;61:396-402.
7. Castillo J, Dávalos A, Naveiro J, Noya M: Excitatory amino acids in relation to infarct size and neurological deficit in ischemic stroke. Stroke 1996;7:1060-1065.
8. Castellanos M, Sobrino T, Millán M, García M, Arenillas J, Nombela F, Brea D, Perez de la Ossa N, Serena J, Vivancos J, Castillo J, Dávalos A: Serum cellular fibronectin and matrix metalloproteinase-9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke: a multicenter confirmatory study. Stroke 2007;38:1855-1859.
9. Mallolas J, Hurtado O, Castellanos M, Blanco M, Sobrino T, Serena J, Vivancos J, Castillo J, Lizasoain I, Moro MA, Dávalos A: A polymorphism in the EAAT2 promoter is associated with higher glutamate concentrations and higher frequency of progressing stroke. J Exp Med 2006;203:711-717.
10. Alexandrov AV, Hall CE, Labiche LA, Wojner AW, Grotta JC: Ischemic stunning of the brain: early recanalization without immediate clinical improvement in acute ischemic stroke. Stroke 2004;35:449-452.
11. www.strokecenter.org/trials.
12. Ferro JM, Dávalos A: Other neuroprotective therapies on trial in acute stroke. Cerebrovasc Dis 2006;21(suppl 2):127-130.
13. Hurtado O, Moro MA, Cárdenas A, Sánchez V, Fernández-Tomé P, Leca JC, Lorenzo P, Secades JJ, Lozano R, Dávalos A, Castillo J, Lizasoain I: Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. Neurobiol Dis 2005;18:336-345.
14. Hurtado O, Cárdenas A, Pradillo JM, Morales JR, Ortego F, Sobrino T, Castillo J, Moro MA, Lizasoain I: A chronic treatment with CDP-choline improves functional recovery and increases neuronal plasticity after experimental stroke. Neurobiol Dis 2007;26:105-111.
15. Dávalos A, Castillo J, Alvarez-Sabín J, Secades JJ, Mercadal J, López S, Cobo E, Warach S, Sherman D, Clark WM, Lozano R: Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials. Stroke 2002;33:2850-2857.
16. www.thelancet.com/journals/lancet/misc/protocol/06PRT-3005.