Differentiation of neonatal rat epithelial cells from biliary origin into immature hepatic cells by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development

Toxicology in Vitro

Volumn 21, Issue 7, 2007, Pages 1325-1331

  Snykers, Sarah ^a   De Kock, Joery ^a   Vanhaecke, Tamara ^a   Rogiers, Vera ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Hepatocytes; Liver embryogenesis; Liver specific growth factors; Postnatal stem cells; Sequential differentiation

Indexed keywords

ALBUMIN; ALPHA FETOPROTEIN; CONNEXIN 32; CONNEXIN 43; CYTOKERATIN 18; CYTOKERATIN 19; DEXAMETHASONE; FIBROBLAST GROWTH FACTOR 4; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 4; INSULIN; MULTIDRUG RESISTANCE PROTEIN 2; ONCOSTATIN M; PREALBUMIN; SCATTER FACTOR; SODIUM SELENITE; TRANSFERRIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; CRYOPRESERVATION; EPITHELIUM CELL; HEMATOPOIETIC STEM CELL; LIVER CELL; LIVER DEVELOPMENT; NEWBORN; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; CELL DIFFERENTIATION; CONNEXIN 43; CRYOPRESERVATION; CYTOKINES; DEXAMETHASONE; EPITHELIAL CELLS; FIBROBLAST GROWTH FACTOR 4; GENE EXPRESSION REGULATION; HEPATOCYTE GROWTH FACTOR; HEPATOCYTES; INSULIN; KERATIN-19; ONCOSTATIN M; PHENOTYPE; RATS; SODIUM SELENITE; TIME FACTORS; TRANSFERRIN;

RATTUS;

EID: 35648991966     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.03.013     Document Type: Article

References (15)

1. Abe K., Niwa H., Iwase K., Takiguchi M., Mori M., Abe S.I., Abe K., and Yamamura K.I. Endoderm-specific gene expression in embryonic stem cells differentiated to embryoid bodies. Experimental Cell Research 229 (1996) 27-34
2. Alison M.R., Vig P., Russo F., Bigger B.W., Amofah E., Themis M., and Forbes S. Hepatic stem cells: From inside and outside the liver?. Cell Proliferation 37 (2004) 1-21
3. Chiba T., Kita K., Zheng Y.W., Yokosuka O., Saisho H., Iwama A., Nakauchi H., and Taniguchi H. Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology 44 (2006) 240-251
4. Dabeva M.D., Petkov P.M., Sandhu J., Oren R., Laconi E., Hurston E., and Shafritz D.A. Proliferation and differentiation of fetal liver epithelial progenitor cells after transplantation into adult rat liver. American Journal of Pathology 156 (2000) 2017-2031
5. Ferrini J.B., Pichard L., Domergue J., and Maurel P. Long-term primary cultures of adult human hepatocytes. Chemical and Biological Interactions 107 (1997) 31-45
6. Guguen-Guillouzo C., Clément B., Baffet G., Beaumont C., Morel-Chany E., Glaise D., and Guillouzo A. Maintenance and reversibility of active albumin secretion by adult rat hepatocytes cocultured with another liver epithelial cell type. Experimental Cell Research 143 (1983) 47-54
7. Henkens T., Vanhaecke T., Papeleu P., Elaut G., Vinken M., Snykers S., and Rogiers V. Rat hepatocyte cultures: Conventional monolayer and cocultures with rat liver epithelial cells. Methods in Molecular Biology 320 (2006) 239-246
8. Kyrmizi I., Hatzis P., Katrakili N., Tronche F., Gonzalez F.J., and Talianidis I. Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Development 20 (2006) 2293-2305
9. Matthews V.B., and Yeoh G.C. Liver stem cells. IUBMB Life 57 (2005) 549-553
10. Oh B.K., Lee C.H., Park C., and Park Y.N. Telomerase regulation and progressive telomere shortening of rat hepatic stem-like epithelial cells during in vitro aging. Experimental Cell Research 298 (2004) 445-454
11. Rogiers, V., Vandenberghe, Y., Callaerts, A., Verleye, G., Cornet, M., Mertens, K., Sonck, W., Vercruysse, A., 1990. Phase I and phase II xenobiotic biotransformation in cultures and co-cultures of adult rat hepatocytes. Biochemical Pharmacology 15, 40(8), 1701-1706.
12. Rogiers V., Akrawi M., Vandenberghe Y., Shephard E., Phillips I., and Vercruysse A. Co-cultures of rat hepatocytes in the study of valproate toxicity. Archives of Toxicology Supplement 15 (1992) 156-159
13. Sergi C., Adam S., Kahl P., and Otto H.F. The remodeling of the primitive human biliary system. Early Human Development 58 (2000) 167-178
14. Shiojiri N., Lemire J.M., and Fausto N. Cell lineages and oval cell progenitors in rat liver development. Cancer Research 51 (1991) 2611-2620
15. Snykers S., Vanhaecke T., Papeleu P., Luttun A., Jiang Y., Vander Heyden Y., Verfaillie C., and Rogiers V. Sequential exposure to cytokines reflecting embryogenesis: The key for in vitro differentiation of adult bone marrow stem cells into functional hepatocyte-like cells. Toxicological Sciences 94 2 (2006) 330-341