Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo

Journal of Smooth Muscle Research

Volumn 43, Issue 4, 2007, Pages 139-144

  Chiba, Yoshihiko ^a   Oshita, Michiko ^a   Sakai, Hiroyasu ^a   Misawa, Miwa ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Allergic rhinitis; Cysteinyl leukotrienes; Nasal mucosal vein; Nasal obstruction; Nitric oxide

Indexed keywords

2 [3 (2 QUINOLYLMETHOXY)ANILINO]BENZOIC ACID; ALLERGEN; CYSTEINE; CYSTEINYL-LEUKOTRIENE; LEUKOTRIENE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEPTIDOLEUKOTRIENE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ACTIVE IMMUNIZATION; ANIMAL; ARTICLE; BLOOD; DRUG ANTAGONISM; DRUG EFFECT; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNOLOGY; MALE; METABOLISM; NOSE MUCOSA; PATHOPHYSIOLOGY; RAT; VASCULARIZATION; VASODILATATION; VEIN; WISTAR RAT;

ALLERGENS; ANIMALS; CYSTEINE; HYPERSENSITIVITY, IMMEDIATE; IMMUNOTHERAPY, ACTIVE; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENES; MALE; NASAL MUCOSA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; QUINOLINES; RATS; RATS, WISTAR; VASODILATION; VEINS;

EID: 35648983412     PISSN: 09168737     EISSN: None     Source Type: Journal    
DOI: 10.1540/jsmr.43.139     Document Type: Article

References (21)

1. Alexander, S.P.H., Mathie, A. and Peters, J.A. (2007). 7TM receptors: leukotriene. Br. J. Pharmacol. 150 (Suppl. 1): S48-S48.
2. Bredt, D.S. and Snyder, S.H. (1994). Nitric oxide: a physiologic messenger molecule. Annu. Rev. Biochem. 63: 175-195.
3. 4-induced relaxation of isolated guinea pig nasal mucosa. Nitric Oxide 15: 142-147.
4. Chiba, Y., Oshita, M., Matsuo, K., Sakai, H. and Misawa, M. (2006). Comparison of norepinephrine responsiveness of mucosal veins in vivo with that of isolated mucosal tissue in vitro in guinea pig nasal mucosa. Am. J. Rhinol. 20: 349-352.
5. 4-induced bronchoconstriction. Allergy 46: 355-361.
6. Imai, A., Nabe, T., Mizutani, N., Sakurai, H., Takenaka, H. and Kohno, S. (2001). Involvement of nitric oxide in pollen-induced biphasic nasal blockage in sensitised guinea pigs. Eur. J. Pharmacol. 423: 63-70.
7. Jiang, R.S. (2006). Efficacy of a leukotriene receptor antagonist in the treatment of perennial allergic rhinitis. J. Otolaryngol. 35: 117-121.
8. Kawamoto, H., Takeno, S. and Yajin, K. (1999). Increased expression of inducible nitric oxide synthase in nasal epithelial cells in patients with allergic rhinitis. Laryngoscope 109: 2015-2020.
9. Kawamoto, H., Takumida, M., Takeno, S., Watanabe, H., Fukushima, N. and Yajin, K. (1998). Localization of nitric oxide synthase in human nasal mucosa with nasal allergy. Acta Otolaryngol. Suppl. 539: 65-70.
10. 1 receptor. Nature 399: 789-793.
11. Maniscalco, M., Sofia, M., Carratu, L. and Higenbottam, T. (2001). Effect of nitric oxide inhibition on nasal airway resistance after nasal allergen challenge in allergic rhinitis. Eur. J. Clin. Invest. 31: 462-466.
12. Miadonna, A., Milazzo, N., Gibelli, S., Salmaso, C., Lorini, M. and Tedeschi, A. (1999). Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. Clin. Exp. Allergy 29: 941-949.
13. Misawa, M. and Chiba, Y. (1993). Repeated antigenic challenge-induced airway hyperresponsiveness and airway inflammation in actively sensitized rats. Jpn. J. Pharmacol. 61: 41-50.
14. 4 in an experimental allergic rhinitis model: contribution of dilated mucosal blood vessels. Jpn. J. Pharmacol. 86: 170-182.
15. Moncada, S., Palmer, R.M. and Higgs, E.A. (1991). Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43: 109-142.
16. Oh, S.J., Min, Y.G., Kim, J.W., Lee, S.J. and Jarin, P.R. (2003). Expression of nitric oxide synthases in nasal mucosa from a mouse model of allergic rhinitis. Ann. Otol. Rhinol. Laryngol. 112: 899-903.
17. Shaw, R.J., Fitzharris, P., Cromwell, O., Wardlaw, A.J. and Kay, A.B. (1985). Allergen-induced release of sulphidopeptide leukotrienes (SRS-A) and LTB4 in allergic rhinitis. Allergy 40: 1-6.
18. Tada, T. and Okumura, K. (1971). Regulation of homocytotropic antibody formation in the rat. I. Feedback regulation by passively administered antibody. J. Immunol. 106: 1002-1011.
19. Wang, D., Clement, P., Smitz, J. and Derde, M.P. (1995). Concentrations of chemical mediators in nasal secretions after nasal allergen challenges in atopic patients. Eur. Arch. Otorhinolaryngol. 252 (Suppl. 1): S40-S43.
20. Wang, D., Smitz, J., Waterschoot, S. and Clement, P. (1997). An approach to the understanding of the nasal early-phase reaction induced by nasal allergen challenge. Allergy 52: 162-167.
21. 2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis. Inflamm. Res. 50: 466-473.